公开(公告)号：EP1720829A1

公开(公告)日：2006-11-15

申请号：EP05732902.1

申请日：2005-02-25

申请人： Sanofi-Aventis

发明人： ABOUABDELLAH, Ahmed ,  BARTSCH-LI, Régine ,  HOORNAERT, Christian ,  RAVET, Antoine

IPC分类号： C07C271/10 ,  C07D215/04 ,  C07D237/08 ,  C07D233/54 ,  C07D235/14 ,  C07D263/32 ,  C07D471/04

CPC分类号： C07D213/54 ,  C07C271/12 ,  C07D209/08 ,  C07D213/40 ,  C07D215/04 ,  C07D215/12 ,  C07D215/227 ,  C07D217/14 ,  C07D231/12 ,  C07D233/64 ,  C07D235/06 ,  C07D239/26 ,  C07D239/42 ,  C07D261/14 ,  C07D273/02 ,  C07D413/04 ,  C07D471/04

摘要： The invention relates to a compound having general formula (I), wherein: A is selected from among one or more X, Y and/or Z groups; X represents an optionally-substituted methylene group; Y represents a C2-alkenylene, optionally substituted, or a C2-alkynylene; Z represents a C3-7 cycloalkyl group; n represents an integer varying between 1 and 7; R1 represents an optionally-substituted heteroaryl or naphthalenyl type group; and R7 represents a hydrogen atom or a C1-6 alkyl group; R8 represents a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-3 alkylene group. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate. Said compounds have an inhibitory activity on the FAAH enzyme.

公开(公告)号：EP1590321A2

公开(公告)日：2005-11-02

申请号：EP04704251.0

申请日：2004-01-22

申请人： Sanofi-Aventis

发明人： ABOUABDELLAH, Ahmed ,  ALMARIO GARCIA, Antonio ,  HOORNAERT, Christian ,  RAVET, Antoine

IPC分类号： C07C271/10 ,  C07C269/06 ,  C07C269/00 ,  C07D263/44 ,  A61K31/27 ,  A61K31/33

CPC分类号： C07C271/12 ,  C07C271/14 ,  C07C271/16 ,  C07C271/18 ,  C07C271/20 ,  C07D213/40 ,  C07D215/12 ,  C07D217/18 ,  C07D241/12 ,  C07D261/08 ,  C07D285/06 ,  C07D307/91 ,  C07D333/20 ,  C07D333/58

摘要： The invention relates to compounds of general formula (I), where n = a whole number from 1 to 7, A is selected from one or several groups X, Y and/or Z, X = C1-2 alkylene, optionally substituted by one or more C1-12 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkylene groups, Y = C2 alkenylene, optionally substituted by one or several C1-12 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkylene groups, Z = a C3-7 cycloalkyl group of formula, (II), (III), m = a whole number from 1 to 5, p and q are whole numbers defined such that p+q is a number from 1 to 5, R1 = H, halogen, hydroxyl, cyano, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4 fluorothioalkyl, R2 = H, halogen, cyano, nitro, hydroxyl, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4-fluorothioalkyl, or an aryl or heteroaryl group, optionally substituted by one or several substituents, R3 is a group of general formula CHR4CONHR5, where R4 = H, or C1-3 alkyl and R5 = H, or C1-3 alkyl, C3-5 cycloalkyl, C3-7-cycloalkyl-C1-6 alkylene, the base, the acid addition salt, the hydrate or the solvate thereof. For application in therapy.

公开(公告)号：EP1590321B1

公开(公告)日：2010-04-28

申请号：EP04704251.0

申请日：2004-01-22

申请人： Sanofi-Aventis

发明人： ABOUABDELLAH, Ahmed ,  ALMARIO GARCIA, Antonio ,  HOORNAERT, Christian ,  RAVET, Antoine

IPC分类号： C07C271/10 ,  C07C269/06 ,  C07C269/00 ,  C07D263/44 ,  A61K31/27 ,  A61K31/33

CPC分类号： C07C271/12 ,  C07C271/14 ,  C07C271/16 ,  C07C271/18 ,  C07C271/20 ,  C07D213/40 ,  C07D215/12 ,  C07D217/18 ,  C07D241/12 ,  C07D261/08 ,  C07D285/06 ,  C07D307/91 ,  C07D333/20 ,  C07D333/58

摘要： The invention relates to compounds of general formula (I), where n = a whole number from 1 to 7, A is selected from one or several groups X, Y and/or Z, X = C1-2 alkylene, optionally substituted by one or more C1-12 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkylene groups, Y = C2 alkenylene, optionally substituted by one or several C1-12 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-6 alkylene groups, Z = a C3-7 cycloalkyl group of formula, (II), (III), m = a whole number from 1 to 5, p and q are whole numbers defined such that p+q is a number from 1 to 5, R1 = H, halogen, hydroxyl, cyano, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4 fluorothioalkyl, R2 = H, halogen, cyano, nitro, hydroxyl, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, C1-4 fluoroalkyl, C1-4 fluoroalkoxy, C1-4-fluorothioalkyl, or an aryl or heteroaryl group, optionally substituted by one or several substituents, R3 is a group of general formula CHR4CONHR5, where R4 = H, or C1-3 alkyl and R5 = H, or C1-3 alkyl, C3-5 cycloalkyl, C3-7-cycloalkyl-C1-6 alkylene, the base, the acid addition salt, the hydrate or the solvate thereof. For application in therapy.

公开(公告)号：EP1720829B1

公开(公告)日：2009-10-14

申请号：EP05732902.1

申请日：2005-02-25

申请人： Sanofi-Aventis

发明人： ABOUABDELLAH, Ahmed ,  BARTSCH-LI, Régine ,  HOORNAERT, Christian ,  RAVET, Antoine

IPC分类号： C07C271/10 ,  C07D215/04 ,  C07D237/08 ,  C07D233/54 ,  C07D235/14 ,  C07D263/32 ,  C07D471/04

CPC分类号： C07D213/54 ,  C07C271/12 ,  C07D209/08 ,  C07D213/40 ,  C07D215/04 ,  C07D215/12 ,  C07D215/227 ,  C07D217/14 ,  C07D231/12 ,  C07D233/64 ,  C07D235/06 ,  C07D239/26 ,  C07D239/42 ,  C07D261/14 ,  C07D273/02 ,  C07D413/04 ,  C07D471/04

摘要： The invention relates to a compound having general formula (I), wherein: A is selected from among one or more X, Y and/or Z groups; X represents an optionally-substituted methylene group; Y represents a C2-alkenylene, optionally substituted, or a C2-alkynylene; Z represents a C3-7 cycloalkyl group; n represents an integer varying between 1 and 7; R1 represents an optionally-substituted heteroaryl or naphthalenyl type group; and R7 represents a hydrogen atom or a C1-6 alkyl group; R8 represents a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-3 alkylene group. The inventive compound takes the form of a base, an acid addition salt, a hydrate or a solvate. Said compounds have an inhibitory activity on the FAAH enzyme.

公开(公告)号：EP2344486A2

公开(公告)日：2011-07-20

申请号：EP09737098.5

申请日：2009-07-21

申请人： Sanofi-Aventis

发明人： ABOUABDELLAH, Ahmed ,  GÖRLITZER, Jochen ,  HAMLEY, Peter ,  RAVET, Antoine

IPC分类号： C07D417/14 ,  A61K31/4535 ,  A61K31/4709 ,  A61P29/00 ,  A61P1/08 ,  A61K31/427 ,  A61P25/00 ,  A61P19/10 ,  A61P33/00 ,  A61P35/00 ,  C07D213/74 ,  C07D211/26 ,  C07D277/24 ,  A61K31/4545 ,  A61P9/00 ,  A61P37/00 ,  A61P1/00

CPC分类号： C07D417/14

摘要： Compound corresponding to general formula (I): in which R
2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C
1-6 -alkyl, C
1-6 -alkoxy or NR
8 R
9 group; n is an integer equal to 1, 2 or 3 and m is an integer equal to 1 or 2; A is a covalent bond or a C
1-8 -alkylene group; R
1 is an optionally substituted aryl or heteroaryl group; R
3 is a hydrogen or fluorine atom, a C
1-6 -alkyl group or a trifluoromethyl group; R
4 is an optionally substituted thiazole; in the form of a base or of an addition salt with an acid. Therapeutic use.