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1.发明授权
公开(公告)号：EP1664058B1
公开(公告)日：2007-11-14
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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2.发明公开
公开(公告)号：EP1664058A1
公开(公告)日：2006-06-07
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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3.发明公开VERFAHREN ZUR SYNTHESE HETEROCYCLISCHER VERBINDUNGEN AUS THIOHARNSTOFFDERIVATEN 有权一种从硫脲衍生物的合成的杂环化合物
公开(公告)号：EP1631552A2
公开(公告)日：2006-03-08
申请号：EP04731903.3
申请日：2004-05-10
发明人： HEINELT, Uwe , LANG, Hans-Jochen
IPC分类号： C07D233/50 , C07D265/08 , C07D235/30 , C07D409/12 , C07D495/04 , C07D413/12 , C07D277/18 , C07D265/18
CPC分类号： C07C335/08 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/20 , C07C2602/08 , C07C2602/14 , C07D233/50 , C07D235/30 , C07D265/08 , C07D265/18 , C07D277/18 , C07D409/12 , C07D413/12 , C07D495/04
摘要： The invention relates to a method illustrated in model 1 for synthesising heterocyclic compounds of formula (I). According to said method, isothiocyanate of formula (II) is reacted with the primary amine of formula (III) to obtain thiourea of formula (IV). The thiourea of formula (IV) is then converted into the heterocycle of formula (I) using a base and a sulfonic acid.
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4.发明授权VERFAHREN ZUR SYNTHESE HETEROCYCLISCHER VERBINDUNGEN AUS THIOHARNSTOFFDERIVATEN 有权VERFAHREN ZUR SYNTHESE HETEROCYCLISCHER VERBINDUNGEN AUS THIHARNSTOFFDERIVATEN
公开(公告)号：EP1631552B1
公开(公告)日：2013-07-03
申请号：EP04731903.3
申请日：2004-05-10
发明人： HEINELT, Uwe , LANG, Hans-Jochen
IPC分类号： C07D233/50 , C07D265/08 , C07D235/30 , C07D409/12 , C07D495/04 , C07D413/12 , C07D277/18 , C07D265/18
CPC分类号： C07C335/08 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/20 , C07C2602/08 , C07C2602/14 , C07D233/50 , C07D235/30 , C07D265/08 , C07D265/18 , C07D277/18 , C07D409/12 , C07D413/12 , C07D495/04
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5.发明授权
公开(公告)号：EP1255724B1
公开(公告)日：2006-08-30
申请号：EP00977604.8
申请日：2000-12-01
发明人： HEINELT, Uwe , LANG, Hans-Jochen , KLEEMANN, Heinz-Werner , SCHWARK, Jan-Robert , WIRTH, Klaus , JANSEN, Hans-Willi
IPC分类号： C07C211/38 , C07C217/56 , A61K31/137
CPC分类号： C07C317/32 , C07B2200/07 , C07C211/38 , C07C211/49 , C07C215/30 , C07C217/58 , C07C217/60 , C07C217/62 , C07C229/38 , C07C237/30 , C07C255/58 , C07C257/18 , C07C311/37 , C07C323/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/68
摘要： The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia), wherein R1, R2 R3, R4, R5, A, B, S1 and S2 have the meanings cited in the claims. Said derivatives are especially suitable as anti-hypertensive agents for reducing or preventing ischaemia-induced damage, as medicaments for use in surgical procedures for treating ischaemias of the nervous system, of a cerebrovascular accident and of a cerebral oedema. The derivatives are also suitable for treating shock, an impaired respiratory impulse, snoring, or for use as a laxative, as an agent against ectoparasites, in the prophylaxis of gall stones, as an anti-atherosclerotic agent, as an agent for treating late complications of diabetes, or for treating cancerous illnesses, fibrotic disorders, endothelial dysfunction and organ hypertrophies and hyperplasias. Said derivatives act as inhibitors of the cellular sodium-proton-antiporter. They also influence serum lipoproteins and can thus be used in the prophylaxis and reversal of atherosclerotic changes.
摘要翻译： 应用程序盘松动substituiertem降冰片衍生物，它们的制备方法，它们作为药物或诊断和药物，其包含具有外切构造氮气下式的内切稠合的五元环的和themSubstituted降冰片衍生物使用I，或具有外切构造氮 和下式的外切稠合的五元环的我泉其中R1，R2，R3，R4，R5，A，B，S1和S2是如在权利要求限定，是高度适合用作抗高血压剂，用于 减少或防止缺血性损伤，用作药物，用于神经系统的缺血的治疗外科手术中风和脑水肿，休克，受损的呼吸驱动的，对于打鼾的治疗，作为泻药，作为对抗剂 体外寄生虫，为防止形成胆结石，因为antiatherosclerotics的，因为对后期糖尿病并发症，癌性疾病，纤维变性疾病，药物恩 内皮功能障碍，和器官hypertrophies和hyperplasias.They是蜂窝钠/质子反向转运蛋白的抑制剂。 他们必须对血清脂蛋白的影响，可以为动脉粥样硬化的变化预防和回归了。所以使用。
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6.发明公开
公开(公告)号：EP1592669A2
公开(公告)日：2005-11-09
申请号：EP04703371.7
申请日：2004-01-20
IPC分类号： C07D233/50 , C07D235/30 , A61K31/4168 , A61K31/4184 , A61P1/10 , A61P9/12 , A61P11/16 , A61P13/12 , A61P33/02 , A61P39/00
CPC分类号： C07D233/50
摘要： The invention relates to compounds of formula (I) whose radicals R1-R8 are defined as in the claims. Compounds of this type are useful in the prevention or treatment of diverse disorders. They can be used, among other things, in the treatment of: kidney diseases such as acute or chronic kidney failure; failures in biliary function; breathing disturbances such as snoring or sleep apnea or; cerebrovascular accidents.
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7.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1613600B1
公开(公告)日：2015-12-23
申请号：EP04719379.2
申请日：2004-03-11
发明人： HOFMEISTER, Armin , HEINELT, Uwe , LANG, Hans-Jochen , FRICK, Wendelin , BLEICH, Markus , WIRTH, Klaus
IPC分类号： C07D217/16 , C07D401/12 , A61K31/47 , A61P9/00 , A61P11/00 , A61P13/12
CPC分类号： C07D401/12 , C07D217/16
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8.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1794128B1
公开(公告)日：2012-01-11
申请号：EP05784511.7
申请日：2005-09-08
IPC分类号： C07D217/22 , A61K31/47 , A61P9/12
CPC分类号： C07D405/12 , C07D217/14 , C07D401/12
摘要： The invention relates to compounds of formula (I) in which R1 to R10 have the meanings as described in the claims. Medicaments containing compounds of this type are useful in preventing or treating various diseases. The compounds can be used, among other things, for renal diseases such as acute or chronic renal failure, for defects of biliary function, for breathing disturbances such as snoring or sleep apnea or for stroke.
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9.发明授权
公开(公告)号：EP1461034B1
公开(公告)日：2006-11-22
申请号：EP02796586.2
申请日：2002-12-09
IPC分类号： A61K31/4168 , A61K31/4184 , A61P11/00 , A61P25/00 , A61P33/14 , A61P43/00 , C07D233/50 , C07D235/02 , C07D235/30
CPC分类号： C07D235/02 , C07D233/50 , C07D235/30
摘要： The invention relates to new imidazolidine-type compounds of formula (I) in which R1 to R7 have the meanings disclosed in the claims. Said compounds represent potent inhibitors of sodium/hydrogen exchanger (NHE), particularly NHE. These novel compounds are used to produce a drug for the therapy or prophylaxis of the central nervous system, lipometabolism, infestations by ectoparasites, dysfunctions of the gall and for improving respiratory drive. The inventive compounds are therefore used for the therapy of respiratory conditions in the following clinical states and diseases: malfunctioning central respiratory drive (e.g. sleep apnoea, sudden infant death, postoperative hypoxia), muscle-related breathing disturbances, breathing disturbances following long-term respiration, breathing disturbances when adapting to high mountain areas, obstructive sleep apnoea and a mixed type of sleep apnoea, acute and chronic lung diseases with hypoxia and hypercapnia. Said compounds also increase the muscle tone in the upper respiratory tract so as to suppress snoring.
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10.发明授权
公开(公告)号：EP1592669B1
公开(公告)日：2007-10-17
申请号：EP04703371.7
申请日：2004-01-20
IPC分类号： C07D233/50 , C07D235/30 , A61K31/4168 , A61K31/4184 , A61P1/10 , A61P9/12 , A61P11/16 , A61P13/12 , A61P33/02 , A61P39/00
CPC分类号： C07D233/50
摘要： The invention relates to compounds of formula (I) whose radicals R1-R8 are defined as in the claims. Compounds of this type are useful in the prevention or treatment of diverse disorders. They can be used, among other things, in the treatment of: kidney diseases such as acute or chronic kidney failure; failures in biliary function; breathing disturbances such as snoring or sleep apnea or; cerebrovascular accidents.
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