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1.发明公开PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开吡啶酮衍生物和它们在治疗，减轻或预防的疾病病毒的使用
公开(公告)号：EP2943469A1
公开(公告)日：2015-11-18
申请号：EP14703276.7
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles
IPC分类号： C07D213/78 , A61K31/4412 , A61P43/00
CPC分类号： C07D213/81 , A61K31/4412 , A61K45/06 , C07D213/78 , C07D213/79
摘要： The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof (II), which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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2.发明授权NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权NAPHTHYRIDINONDERIVATE和它们在治疗，减轻或预防疾病病毒的
公开(公告)号：EP2945945B1
公开(公告)日：2016-08-31
申请号：EP14703780.8
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles , SIDDURI, Achyutharao
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： A61K31/519 , A61K31/4375 , A61K31/4985 , A61K31/513 , A61K45/06 , C07D401/04 , C07D471/02 , C07D471/04
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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3.发明公开NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权NAPHTHYRIDINONDERIVATE和它们在治疗，减轻或预防疾病病毒的
公开(公告)号：EP2945945A1
公开(公告)日：2015-11-25
申请号：EP14703780.8
申请日：2014-01-07
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , BUSCHMANN, Helmut , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau , HAWLEY, Ronald Charles , SIDDURI, Achyutharao
IPC分类号： C07D471/04 , A61K31/4375 , A61P31/12
CPC分类号： A61K31/519 , A61K31/4375 , A61K31/4985 , A61K31/513 , A61K45/06 , C07D401/04 , C07D471/02 , C07D471/04
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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4.发明公开PYRIDOPYRAZINE COMPOUNDS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA 审中-公开PYRIDOPYRAZINVERBINDUNGEN和它们在治疗，减轻或预防感冒
公开(公告)号：EP3166943A1
公开(公告)日：2017-05-17
申请号：EP15745406.7
申请日：2015-07-06
发明人： SCHULZ-GASCH, Tanja , WEIKERT, Robert , NEIDHART, Werner , BUSCHMANN, Helmut , SZOLAR, Oliver , WOLKERSTORFER, Andrea , HANDLER, Norbert , ROCH, Franz-Ferdinand , CUSACK, Stephen
IPC分类号： C07D471/04 , A61K31/4985 , A61P31/12
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameliorating or preventing influenza. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（V）中，任选地在药学上可接受的盐，溶剂合物，多晶型物，共药物，共结晶体，前药，互变异构体，外消旋体，对映异构体，或非对映体或混合物的形式存在的化合物，这是有用 在治疗，缓解或预防流感。 进一步，特定的组合疗法是游离缺失盘。
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5.发明公开DIHYDROXYPYRIMIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开羟基嘧啶二氧化碳衍生物及其用于治疗，减轻或预防疾病病毒的
公开(公告)号：EP2885289A1
公开(公告)日：2015-06-24
申请号：EP13759141.8
申请日：2013-08-05
发明人： BUSCHMANN, Helmut , WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau
IPC分类号： C07D403/06 , C07D239/52 , C07D239/557 , A61K31/505 , A61K31/506 , A61K31/513 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20
CPC分类号： C07D239/557 , A61K31/513 , A61K45/06 , C07D239/52 , C07D403/06
摘要： The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, formula (Di), (Dii), (Diii) which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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6.发明公开7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开7-氧代-4,7-二氢[1,5-A]其中治疗，病毒疾病或救济预防是USED嘧啶衍生物
公开(公告)号：EP2861232A1
公开(公告)日：2015-04-22
申请号：EP13730131.3
申请日：2013-05-23
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： A61K31/519 , A61P31/12 , A61P31/16
CPC分类号： A61K31/519 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound having the general formula (C), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（C），任选地在药学上可接受的盐，溶剂合物，多晶型物，共药物，共结晶体，前药，互变异构体，外消旋体，对映异构体，或非对映体或混合物的形式存在的化合物，这是有用 治疗，改善或预防的病毒性疾病。 进一步，特定的组合疗法是游离缺失盘。
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7.发明授权PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权嘧啶-4- ON衍生物及其在治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2794616B1
公开(公告)日：2016-06-29
申请号：EP12787384.2
申请日：2012-10-19
发明人： CLASSEN-HOUBEN, Dirk , WOLKERSTORFER, Andrea , SZOLAR, Oliver , SMITH, Mark , SO, Sung-Sau , CUSACK, Stephen , LANGER, Thierry , GIETHLEN, Bruno , MORICE, Christophe , MICHAUT-SIMON, Céline , JUNG, Laurence
IPC分类号： C07D495/04 , A61K31/519 , A61P31/12
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K45/06
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8.发明公开7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权7-氧代THIAZOLOPYRIDINKOHLENSÄUREDERIVATE及其用途用于治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2864338A2
公开(公告)日：2015-04-29
申请号：EP13730130.5
申请日：2013-05-23
申请人： Savira Pharmaceuticals GmbH , F.Hoffmann-La Roche AG , European Molecular Biology Laboratory (EMBL)
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： C07D513/04 , A61K31/429 , A61P31/12
CPC分类号： C07D513/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diasiereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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9.发明公开HETEROARYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开HETEROARYLHYDROXAMSÄUREDERIVATE及其用途用于治疗，减轻或预防疾病病毒的
公开(公告)号：EP2776396A2
公开(公告)日：2014-09-17
申请号：EP12786860.2
申请日：2012-10-19
发明人： CLASSEN-HOUBEN, Dirk , WOLKERSTORFER, Andrea , SZOLAR, Oliver , SMITH, Mark , SO, Sung-Sau , CUSACK, Stephen , LANGER, Thierry , GIETHLEN, Bruno , MORICE, Christophe , MICHAUT-SIMON, Céline , ZUBIETA, Chloe
IPC分类号： C07D213/81 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/08 , C07D413/04 , C07D471/04 , C07D495/04 , A61K31/44 , A61P31/16
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D215/48 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/08 , C07D413/04 , C07D471/04 , C07D493/10 , C07D495/04
摘要： The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or dsasiereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式I，任选呈其药学上可接受的盐，溶剂合物，多晶型物，前药，互变异构体，外消旋体，对映体，或对映异构体或其混合物的形式，其可用于治疗，改善或预防有用的化合物，在所有 病毒性疾病。 进一步，特定的组合疗法是游离缺失盘。
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10.发明公开DIHYDROPYRIDOPYRAZINE-1,8-DIONES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF VIRAL DISEASES 审中-公开DIHYDROPYRIDOPYRAZIN -1,8-二酮和它们在治疗中，RELIEF或预防病毒病
公开(公告)号：EP3166951A1
公开(公告)日：2017-05-17
申请号：EP15745155.0
申请日：2015-07-06
发明人： SCHULZ-GASCH, Tanja , WEIKERT, Robert , NEIDHART, Werner , BUSCHMANN, Helmut , SZOLAR, Oliver , WOLKERSTORFER, Andrea , HANDLER, Norbert , ROCH, Franz-Ferdinand , CUSACK, Stephen
IPC分类号： C07D519/00 , A61K31/499 , A61P31/12
CPC分类号： A61K31/506 , A61K31/4985 , A61K45/06 , C07D471/04 , C07D519/00
摘要： The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（V）中，任选地在药学上可接受的盐，溶剂合物，多晶型物，共药物，共结晶体，前药，互变异构体，外消旋体，对映异构体，或非对映体或混合物的形式存在的化合物，这是有用 在治疗，预防或ameloriating病毒性疾病。 进一步，特定的组合疗法是游离缺失盘。
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