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1.发明授权7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权7-氧代THIAZOLOPYRIDINKOHLENSÄUREDERIVATE及其用途用于治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2864338B1
公开(公告)日：2016-12-14
申请号：EP13730130.5
申请日：2013-05-23
申请人： Savira Pharmaceuticals GmbH , F.Hoffmann-La Roche AG , European Molecular Biology Laboratory (EMBL)
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： C07D513/04 , A61K31/429 , A61P31/12
CPC分类号： C07D513/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04
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2.发明公开7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权7-氧代THIAZOLOPYRIDINKOHLENSÄUREDERIVATE及其用途用于治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2864338A2
公开(公告)日：2015-04-29
申请号：EP13730130.5
申请日：2013-05-23
申请人： Savira Pharmaceuticals GmbH , F.Hoffmann-La Roche AG , European Molecular Biology Laboratory (EMBL)
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： C07D513/04 , A61K31/429 , A61P31/12
CPC分类号： C07D513/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diasiereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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3.发明公开DIHYDROXYPYRIMIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开羟基嘧啶二氧化碳衍生物及其用于治疗，减轻或预防疾病病毒的
公开(公告)号：EP2885289A1
公开(公告)日：2015-06-24
申请号：EP13759141.8
申请日：2013-08-05
发明人： BUSCHMANN, Helmut , WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SMITH, Mark , SO, Sung-Sau
IPC分类号： C07D403/06 , C07D239/52 , C07D239/557 , A61K31/505 , A61K31/506 , A61K31/513 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20
CPC分类号： C07D239/557 , A61K31/513 , A61K45/06 , C07D239/52 , C07D403/06
摘要： The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, formula (Di), (Dii), (Diii) which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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4.发明公开7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开7-氧代-4,7-二氢[1,5-A]其中治疗，病毒疾病或救济预防是USED嘧啶衍生物
公开(公告)号：EP2861232A1
公开(公告)日：2015-04-22
申请号：EP13730131.3
申请日：2013-05-23
发明人： WOLKERSTORFER, Andrea , SZOLAR, Oliver , HANDLER, Norbert , CUSACK, Stephen , SAUVAÎTRE, Thibault , MICHAUT-SIMON, Céline , MORICE, Christophe , GIETHLEN, Bruno , LANGER, Thierry , SMITH, Mark , SO, Sung-Sau , CLASSEN-HOUBEN, Dirk , BUSCHMANN, Helmut
IPC分类号： A61K31/519 , A61P31/12 , A61P31/16
CPC分类号： A61K31/519 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound having the general formula (C), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式（C），任选地在药学上可接受的盐，溶剂合物，多晶型物，共药物，共结晶体，前药，互变异构体，外消旋体，对映异构体，或非对映体或混合物的形式存在的化合物，这是有用 治疗，改善或预防的病毒性疾病。 进一步，特定的组合疗法是游离缺失盘。
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5.发明公开PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权嘧啶-4- ON衍生物及其在治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2794616A1
公开(公告)日：2014-10-29
申请号：EP12787384.2
申请日：2012-10-19
发明人： CLASSEN-HOUBEN, Dirk , WOLKERSTORFER, Andrea , SZOLAR, Oliver , SMITH, Mark , SO, Sung-Sau , CUSACK, Stephen , LANGER, Thierry , GIETHLEN, Bruno , MORICE, Christophe , MICHAUT-SIMON, Céline , JUNG, Laurence
IPC分类号： C07D495/04 , A61K31/519 , A61P31/12
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, Formula (II) which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
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6.发明授权PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 有权嘧啶-4- ON衍生物及其在治疗，减轻或预防一种疾病病毒的
公开(公告)号：EP2794616B1
公开(公告)日：2016-06-29
申请号：EP12787384.2
申请日：2012-10-19
发明人： CLASSEN-HOUBEN, Dirk , WOLKERSTORFER, Andrea , SZOLAR, Oliver , SMITH, Mark , SO, Sung-Sau , CUSACK, Stephen , LANGER, Thierry , GIETHLEN, Bruno , MORICE, Christophe , MICHAUT-SIMON, Céline , JUNG, Laurence
IPC分类号： C07D495/04 , A61K31/519 , A61P31/12
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K45/06
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7.发明公开HETEROARYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE 审中-公开HETEROARYLHYDROXAMSÄUREDERIVATE及其用途用于治疗，减轻或预防疾病病毒的
公开(公告)号：EP2776396A2
公开(公告)日：2014-09-17
申请号：EP12786860.2
申请日：2012-10-19
发明人： CLASSEN-HOUBEN, Dirk , WOLKERSTORFER, Andrea , SZOLAR, Oliver , SMITH, Mark , SO, Sung-Sau , CUSACK, Stephen , LANGER, Thierry , GIETHLEN, Bruno , MORICE, Christophe , MICHAUT-SIMON, Céline , ZUBIETA, Chloe
IPC分类号： C07D213/81 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/08 , C07D413/04 , C07D471/04 , C07D495/04 , A61K31/44 , A61P31/16
CPC分类号： C07D213/81 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D215/48 , C07D217/26 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/08 , C07D413/04 , C07D471/04 , C07D493/10 , C07D495/04
摘要： The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or dsasiereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
摘要翻译： 本发明涉及具有通式I，任选呈其药学上可接受的盐，溶剂合物，多晶型物，前药，互变异构体，外消旋体，对映体，或对映异构体或其混合物的形式，其可用于治疗，改善或预防有用的化合物，在所有 病毒性疾病。 进一步，特定的组合疗法是游离缺失盘。
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公开(公告)号：EP2731932B1
公开(公告)日：2015-12-30
申请号：EP12734923.1
申请日：2012-07-09
发明人： BILOTTA, Joseph Anthony , CHEUNG, Adrian Wai-Hing , FIROOZNIA, Fariborz , GUERTIN, Kevin Richard , HAYDEN, Stuart , HAYNES, Nancy-Ellen , LUKACS-LESBURG, Christine M. , MARCOPULOS, Nicholas , MERTZ, Eric , QI, Lida , QIAN, Yimin , SO, Sung-Sau , TAN, Jenny , THAKKAR, Kshitij Chhabilbhai
IPC分类号： C07D215/48 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D215/233 , A61K31/4709 , A61P3/10 , A61P19/00 , A61P35/00 , A61P25/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP2513103A1
公开(公告)日：2012-10-24
申请号：EP10792890.5
申请日：2010-12-13
发明人： BERTHEL, Steven Joseph , CHEN, Li , CORBETT, Wendy Lea , FENG, Lichun , HAYNES, Nancy-Ellen , KESTER, Robert Francis , SO, Sung-Sau , TILLEY, Jefferson Wright
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07C2601/04 , C07C2601/06 , C07D401/06 , C07D403/10 , C07D405/06
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供了式（I）化合物：及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢性疾病和病症，例如II型糖尿病。
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公开(公告)号：EP2504324A1
公开(公告)日：2012-10-03
申请号：EP10782584.6
申请日：2010-11-19
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R
2 , R
3 , R
4 , R
5 , and R
6 are as defined herein.
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