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公开(公告)号：EP1285058A2
公开(公告)日：2003-02-26
申请号：EP01938210.0
申请日：2001-05-09
CPC分类号： C12N5/0609 , A61K31/00 , A61K31/575 , C12N2501/11 , C12N2501/392 , C12N2501/70 , C12N2517/10
摘要： The present invention relates to the use of FF-MAS and/or MAS analogues for the fertilization of aged oocytes.
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2.发明公开STEROID COMPOUNDS, USE OF THESE COMPOUNDS FOR THE PREPARATION OF MEIOSIS-REGULATING MEDICAMENTS AND METHOD FOR THE PREPARATION OF THESE COMPOUNDS 审中-公开氨基甾化合物，它们的使用生产减数分裂调节药物在AND A VEFAHREN FOR PRODUCING
公开(公告)号：EP1401856A2
公开(公告)日：2004-03-31
申请号：EP02740430.0
申请日：2002-03-20
CPC分类号： C07J41/005 , C07J43/003
摘要： The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C17 of the steroid skeleton via a spacer A.
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公开(公告)号：EP1077992B1
公开(公告)日：2003-12-10
申请号：EP99919126.5
申请日：1999-05-11
申请人： NOVO NORDISK A/S
发明人： FAARUP, Peter , GRONVALD, Frederik, Christian , BLUME, Thorsten , MURRAY, Anthony , BREINHOLT, Jens
IPC分类号： C07J9/00 , C07J21/00 , C07J41/00 , C07J43/00 , A61K31/575
CPC分类号： C07J41/0094 , C07J9/00 , C07J53/004
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公开(公告)号：EP1077992A1
公开(公告)日：2001-02-28
申请号：EP99919126.5
申请日：1999-05-11
申请人： NOVO NORDISK A/S
发明人： FAARUP, Peter , GRONVALD, Frederik, Christian , BLUME, Thorsten , MURRAY, Anthony , BREINHOLT, Jens
IPC分类号： C07J9/00 , C07J21/00 , C07J41/00 , C07J43/00 , A61K31/575
CPC分类号： C07J41/0094 , C07J9/00 , C07J53/004
摘要： Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
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5.发明授权VERFAHREN ZUR HERSTELLUNG VON 4,4-DIMETHYL-5 ALPHA-CHOLESTA-8,14,24-TRIEN-3 BETA-OL UND ZWISCHENPRODUKTE IM VERFAHREN (I) 有权用于生产4,4-二甲基-5- ALPHA胆甾8,14,24三烯3 BETA-OL和中间产品在方法（I）
公开(公告)号：EP1070082B1
公开(公告)日：2003-09-17
申请号：EP99924752.1
申请日：1999-03-26
CPC分类号： C07J9/00 , C07J7/0095 , C07J51/00
摘要： The invention relates to a new method comprising different ways of producing compounds of formula (1). The invention further relates to the hitherto unknown compounds of formulas (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) and (15), also in the form of intermediate products.
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6.发明公开
公开(公告)号：EP1664079A1
公开(公告)日：2006-06-07
申请号：EP04763197.3
申请日：2004-07-13
CPC分类号： C07J43/003
摘要： The present invention relates to thiomorpholino steroid compounds of general formula (I), which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by a thiomorpholino moiety bonded to C17 of the steroid skeleton via an alkylen spacer.
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7.发明公开14$g(b)-H-STEROLS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEIOSIS REGULATING MEDICAMENTS 审中-公开14.BETA.STEROLE，其药物组合物及其用途在生产减数分裂调节药
公开(公告)号：EP1177205A1
公开(公告)日：2002-02-06
申请号：EP00929510.6
申请日：2000-05-05
发明人： ESPERLING, Peter , KUHNKE, Joachim , LAURENT, Henry , BLUME, Thorsten , HEGELE-HARTUNG, Christa , LESSL, Monika
IPC分类号： C07J9/00 , C07J15/00 , A61K31/575 , A61P15/16 , A61P15/18
摘要： The present invention relates to pharmaceutically active 14β-H-sterols, to pharmaceutical compositions comprising them and to the use of these novel compounds for the preparation of medicaments. More particularly it has been found that the 14β-H-sterols of the invention can be used for regulating meiosis.
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8.发明公开VERFAHREN ZUR HERSTELLUNG VON 4,4-DIMETHYL-5 ALPHA-CHOLESTA-8,14,24-TRIEN-3 BETA-OL UND ZWISCHENPRODUKTE IM VERFAHREN (I) 有权用于生产4,4-二甲基-5- ALPHA胆甾8,14,24三烯3 BETA-OL和中间产品在方法（I）
公开(公告)号：EP1070082A1
公开(公告)日：2001-01-24
申请号：EP99924752.1
申请日：1999-03-26
CPC分类号： C07J9/00 , C07J7/0095 , C07J51/00
摘要： The invention relates to a new method comprising different ways of producing compounds of formula (1). The invention further relates to the hitherto unknown compounds of formulas (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14) and (15), also in the form of intermediate products.
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9.发明公开BENZIMIDAZOLDERIVATE ZUR BEHANDLUNG VON MIT MIKROGLIA-AKTIVIERUNG ASSOZIIERTEN ERKRANKUNGEN WIE INFLAMMATORISCHE, ALLERGISCHE, INFEKTIÖSE ODER AUTOIMMUNE ERKRANKUNGEN 有权苯并咪唑衍生物与小胶质细胞活化有关的病症AS炎性，过敏性,,传染性或自身免疫性疾病TREAT
公开(公告)号：EP1404656A1
公开(公告)日：2004-04-07
申请号：EP02740766.7
申请日：2002-07-05
发明人： BLUME, Thorsten , HALFBRODT, Wolfgang , KUHNKE, Joachim , MOENNING, Ursula , SCHNEIDER, Herbert
IPC分类号： C07D235/26 , C07D235/28 , C07D235/30 , A61K31/4184 , A61P31/00 , A61P37/06 , A61P37/08 , C07D401/12
CPC分类号： C07D401/12 , C07D235/26 , C07D235/28 , C07D235/30
摘要： The invention relates to novel benzimidazole derivatives with general formula (I), whereby the radicals R?1, R2, R3¿, A, B, Y and Z have the meanings as cited in the description and in the claims. The invention also relates to the use of these compounds for producing a medicament used for the treatment and prophylaxis of diseases associated with a microglia-activation, and to pharmaceutical preparations containing these compounds.
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10.发明公开1-ALKYL-2-ARYL-BENZIMIDAZOLDERIVATE, DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN SOWIE DIESE DERIVATE ENTHALTENDE PHARMAZEUTISCHE PRÄPARATE 审中-公开1-烷基-2-芳基 - 苯并咪唑衍生物，它们在药物的生产和它们的衍生物药物制剂
公开(公告)号：EP1404321A1
公开(公告)日：2004-04-07
申请号：EP02762333.9
申请日：2002-07-06
发明人： BLUME, Thorsten , HALFBRODT, Wolfgang , KUHNKE, Joachim , MOENNING, Ursula , ELGER, Bernd , SCHNEIDER, Herbert
IPC分类号： A61K31/4184 , C07D235/18 , C07D401/04 , C07D409/04 , C07D403/04 , C07D405/04 , C07D413/04 , C07D403/06 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/18 , C07D401/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要： The invention relates to novel benzimidazole derivatives of general formula (I), wherein the groups R?1, R2, R3¿, A, B and Y are defined as per the definition and the claims. The invention also relates to the use of these compounds for producing a medicament for the prophylaxis and treatment of diseases linked to the activation of microglia and to pharmaceutical preparations containing said compounds.
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