-
公开(公告)号：EP0267779A3
公开(公告)日：1990-01-17
申请号：EP87309935.2
申请日：1987-11-10
CPC分类号： C07K14/5409 , A61K38/00
摘要： A novel immune system mediator, termed pleiotropic immune factor (PIF) is provided which enhances the secretion of immunoglobulin, particularly IgA, and which promotes the growth and differentiation of eosinophils. The human PIF amino acid sequence is disclosed, and a synthetic gene is provided for cassette mutagenesis in a pcD plasmid. Mutant and native human PIFs are expressed in COS 7 monkey cells.
-
2.发明公开Antibodies to mammalian interleukin-4 and peptides useful as antigens in their production 失效抗体对哺乳动物白细胞介素-4和用作抗原用于生产它们的肽。
公开(公告)号：EP0675136A3
公开(公告)日：1996-03-13
申请号：EP95108150.4
申请日：1986-11-19
发明人： Lee, Frank , Yokota, Takashi , Arai, Ken-ichi , Mosmann, Timothy , Rennick, Donna , Smith, Craig
IPC分类号： C07K16/24 , C07K14/54 , A61K39/395 , G01N33/68
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.
-
3.发明公开Antibodies to mammalian interleukin-4 and peptides useful as antigens in their production 失效Antikörpergegen Saugetier-Interleukin-4和肽verwendbar als Antigenenfürderen Herstellung。
公开(公告)号：EP0675136A2
公开(公告)日：1995-10-04
申请号：EP95108150.4
申请日：1986-11-19
发明人： Lee, Frank , Yokota, Takashi , Arai, Ken-ichi , Mosmann, Timothy , Rennick, Donna , Smith, Craig
IPC分类号： C07K16/24 , C07K14/54 , A61K39/395 , G01N33/68
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.
摘要翻译： 提供哺乳动物白细胞介素-4和突变蛋白的抗体，特别是天然人IL-4，以及在其生产中可用作抗原的肽。 公开了能够编码哺乳动物IL-4及其突变蛋白的核酸。
-
4.发明公开Human pleiotropic immune factor and muteins thereof 失效Menschlicher pleitroper Immunfaktor und dessen Muteine。
公开(公告)号：EP0267779A2
公开(公告)日：1988-05-18
申请号：EP87309935.2
申请日：1987-11-10
CPC分类号： C07K14/5409 , A61K38/00
摘要： A novel immune system mediator, termed pleiotropic immune factor (PIF) is provided which enhances the secretion of immunoglobulin, particularly IgA, and which promotes the growth and differentiation of eosinophils. The human PIF amino acid sequence is disclosed, and a synthetic gene is provided for cassette mutagenesis in a pcD plasmid. Mutant and native human PIFs are expressed in COS 7 monkey cells.
摘要翻译： 提供了一种称为多效免疫因子（PIF）的新型免疫系统介质，其增强免疫球蛋白分泌，特别是IgA，并促进嗜酸性粒细胞的生长和分化。 公开了人PIF氨基酸序列，并提供了在pcD质粒中进行盒式诱变的合成基因。 突变体和天然人类PIF在COS7猴细胞中表达。
-
公开(公告)号：EP0230107A1
公开(公告)日：1987-07-29
申请号：EP86309041.1
申请日：1986-11-19
发明人： Lee, Frank , Yokota, Takashi , Arai, Ken-ichi , Mosmann, Timothy , Rennick, Donna , Smith, Craig
CPC分类号： C07K16/247 , A61K38/00 , C07K14/5406 , C07K2319/02 , C12N15/66 , C12N15/70 , C12N15/86 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译： 提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。 本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与所公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。
-
-
-
-
搜索结果
5 条记录 (耗时 0.019 秒)
