公开(公告)号：EP0675136A3

公开(公告)日：1996-03-13

申请号：EP95108150.4

申请日：1986-11-19

申请人： Schering Biotech Corporation

发明人： Lee, Frank ,  Yokota, Takashi ,  Arai, Ken-ichi ,  Mosmann, Timothy ,  Rennick, Donna ,  Smith, Craig

IPC分类号： C07K16/24 ,  C07K14/54 ,  A61K39/395 ,  G01N33/68

CPC分类号： C07K16/247 ,  A61K38/00 ,  C07K14/5406 ,  C07K2319/02 ,  C12N15/66 ,  C12N15/70 ,  C12N15/86 ,  C12N2710/16243

摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.

公开(公告)号：EP0675136A2

公开(公告)日：1995-10-04

申请号：EP95108150.4

申请日：1986-11-19

申请人： Schering Biotech Corporation

发明人： Lee, Frank ,  Yokota, Takashi ,  Arai, Ken-ichi ,  Mosmann, Timothy ,  Rennick, Donna ,  Smith, Craig

IPC分类号： C07K16/24 ,  C07K14/54 ,  A61K39/395 ,  G01N33/68

CPC分类号： C07K16/247 ,  A61K38/00 ,  C07K14/5406 ,  C07K2319/02 ,  C12N15/66 ,  C12N15/70 ,  C12N15/86 ,  C12N2710/16243

摘要： Antibodies to mammalian Interleukin-4 and muteins are provided, especially to native human IL-4s, as well as peptides useful as antigens in their production. Nucleic acids are disclosed which are capable of coding for the mammalian IL-4s and their muteins.

摘要翻译： 提供哺乳动物白细胞介素-4和突变蛋白的抗体，特别是天然人IL-4，以及在其生产中可用作抗原的肽。 公开了能够编码哺乳动物IL-4及其突变蛋白的核酸。

公开(公告)号：EP0230107A1

公开(公告)日：1987-07-29

申请号：EP86309041.1

申请日：1986-11-19

申请人： Schering Biotech Corporation

发明人： Lee, Frank ,  Yokota, Takashi ,  Arai, Ken-ichi ,  Mosmann, Timothy ,  Rennick, Donna ,  Smith, Craig

IPC分类号： C07K15/00 ,  C07K13/00 ,  C12N15/00 ,  C12P21/00 ,  A61K37/02

CPC分类号： C07K16/247 ,  A61K38/00 ,  C07K14/5406 ,  C07K2319/02 ,  C12N15/66 ,  C12N15/70 ,  C12N15/86 ,  C12N2710/16243

摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.

摘要翻译： 提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。 本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与所公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。