公开(公告)号：EP2078004A1

公开(公告)日：2009-07-15

申请号：EP07853035.9

申请日：2007-10-29

申请人： Schering Corporation

发明人： SHIPPS, Gerald, W., Jr. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  FISCHMANN, Thierry, O. ,  DUCA, Jose, S. ,  RICHARDS, Matthew ,  ZENG, Hongbo ,  SUN, Binyuan ,  REDDY, Panduranga, A. ,  ZHAO, Lianyun ,  TANG, Shuyi ,  WONG, Tzu, T. ,  TADIKONDA, Praveen, K. ,  TORRES, Luis, E. ,  SIDDIQUI, M., Arshad ,  DWYER, Michael, P. ,  KEERTIKAR, Kartik, M. ,  GUZI, Timothy, J.

IPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04 ,  A61K31/501 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D277/56 ,  A61K31/435 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/06 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04 ,  A61K2300/00

摘要： The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

公开(公告)号：EP2078003A1

公开(公告)日：2009-07-15

申请号：EP07853013.6

申请日：2007-10-29

申请人： Schering Corporation

发明人： SHIPPS, Gerald, W., Jr. ,  CHENG, Cliff, C. ,  HUANG, Xiaohua ,  FISCHMANN, Thierry, O. ,  DUCA, Jose, S. ,  RICHARDS, Matthew ,  ZENG, Hongbo ,  SUN, Binyuan ,  REDDY, Panduranga, A. ,  WONG, Tzu, T. ,  TADIKONDA, Praveen, K. ,  SIDDIQUI, M., Arshad ,  LABROLI, Marc, M. ,  POKER, Cory ,  GUZI, Timothy, J.

IPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  A61K31/426 ,  A61K31/427 ,  A61P35/00

CPC分类号： C07D277/56 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10

摘要： The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

摘要翻译： 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性疾病，癌症，抗增殖性疾病，炎症，关节炎，中枢神经 系统障碍，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。

公开(公告)号：EP2448942A1

公开(公告)日：2012-05-09

申请号：EP10730016.2

申请日：2010-06-30

申请人： Schering Corporation

发明人： CHENG, Cliff, C. ,  ZENG, Hongbo ,  SHIPPS, Jr., Gerald, W. ,  DENG, Yongqi ,  MENG, Zhaoyang ,  ZHAO, Lianyun ,  NAN, Yang ,  SUN, Binyuan ,  LIU, Duan ,  REDDY, Panduranga, A. ,  SIDDIQUI, M., Arshad

IPC分类号： C07D487/14 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/14

摘要： The present invention provides Fused Tricyclic Compounds of the Formula (I) wherein Q, R
1 , R
2 , R
3 , and R
4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders.

公开(公告)号：EP1945644A2

公开(公告)日：2008-07-23

申请号：EP06837322.4

申请日：2006-11-08

申请人： Schering Corporation

发明人： ZHAO, Lianyun ,  CURRAN, Patrick, J. ,  BELANGER, David, B. ,  HAMANN, Blake ,  REDDY, Panduranga, A. ,  PARUCH, Kamil ,  GUZI, Timothy. J. ,  DWYER, Michael, P. ,  SIDDIQUI, M., Arshad ,  TADIKONDA, Praveen, K.

IPC分类号： C07D487/04 ,  A61K31/498 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

公开(公告)号：EP1957058A1

公开(公告)日：2008-08-20

申请号：EP06844652.5

申请日：2006-11-29

申请人： Schering Corporation

发明人： SIDDIQUI, M., Arshad ,  MANSOOR, Umar, Faruk ,  REDDY, Panduranga, A. ,  MADISON, Vincent, S.

IPC分类号： A61K31/16 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D209/08 ,  C07D209/44 ,  C07D211/10 ,  C07D211/18 ,  C07D211/32 ,  C07D211/46 ,  C07D211/54 ,  C07D211/58 ,  C07D211/62 ,  C07D211/64

CPC分类号： C07D207/06 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/14 ,  C07C235/16 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2602/08 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D207/20 ,  C07D207/26 ,  C07D209/08 ,  C07D209/44 ,  C07D211/10 ,  C07D211/18 ,  C07D211/32 ,  C07D211/46 ,  C07D211/54 ,  C07D211/58 ,  C07D211/62 ,  C07D211/64 ,  C07D213/40 ,  C07D213/74 ,  C07D215/14 ,  C07D217/06 ,  C07D231/12 ,  C07D233/26 ,  C07D239/26 ,  C07D243/08 ,  C07D263/32 ,  C07D295/135 ,  C07D295/185 ,  C07D307/52 ,  C07D307/68 ,  C07D333/20 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D513/04

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, aggrecanase, ADMP, LpxC, ADAMs, TACE, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPs，aggrecanase，ADMP，LpxC，ADAMs，TACE，TNF- α或其组合。

公开(公告)号：EP1945643A2

公开(公告)日：2008-07-23

申请号：EP06837219.2

申请日：2006-11-08

申请人： Schering Corporation

发明人： GUZI, Timothy, J. ,  PARUCH, Kamil ,  DWYER, Michael, P. ,  ZHAO, Lianyun ,  CURRAN, Patrick, J. ,  BELANGER, David, B. ,  HAMANN, Blake ,  REDDY, Panduranga, A. ,  SIDDIQUI, Arshad, M.

IPC分类号： C07D487/04 ,  A61K31/498 ,  A61P35/00

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.