公开(公告)号：EP1778676B1

公开(公告)日：2010-08-25

申请号：EP05771446.1

申请日：2005-07-13

申请人： Schering Corporation

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Guowei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

公开(公告)号：EP0823896B1

公开(公告)日：2001-07-11

申请号：EP96915341.0

申请日：1996-05-01

申请人： SCHERING CORPORATION

发明人： REICHARD, Gregory, A. ,  ASLANIAN, Robert, G. ,  ALAIMO, Cheryl, L. ,  KIRKUP, Michael, P. ,  LUPO, Andrew ,  MANGIARACINA, Pietro ,  MCCORMICK, Kevin, D. ,  PIWINSKI, John, J. ,  SHANKAR, Bandarpalle ,  SHIH, Neng-Yang ,  SPITLER, James, M. ,  TING, Pauline, C. ,  GANGULY, Ashit ,  CARRUTHERS, Nicholas, I.

IPC分类号： C07D211/52 ,  C07D211/58 ,  C07D211/76 ,  C07D295/12 ,  C07D295/18 ,  C07D401/04 ,  C07D417/12 ,  C07D413/14 ,  C07D413/12 ,  A61K31/445

CPC分类号： C07D295/185 ,  C07D211/52 ,  C07D211/58 ,  C07D211/76 ,  C07D295/13 ,  C07D333/22 ,  C07D401/04 ,  C07D401/06 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

公开(公告)号：EP1778676A1

公开(公告)日：2007-05-02

申请号：EP05771446.1

申请日：2005-07-13

申请人： SCHERING CORPORATION

发明人： YU, Wensheng ,  TONG, Ling ,  CHEN, Lei ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  SHIH, Neng-Yang ,  MADISON, Vincent, S. ,  ZHOU, Gouwei ,  ORTH, Peter ,  GUO, Zhuyan ,  WONG, Michael, K. C. ,  YANG, De-Yi ,  KIM, Seong, Heon ,  SHANKAR, Bandarpalle

IPC分类号： C07D403/06 ,  C07D417/14 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  A61P43/00 ,  A61P29/00 ,  A61K31/4178

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

公开(公告)号：EP0823896A1

公开(公告)日：1998-02-18

申请号：EP96915341.0

申请日：1996-05-01

申请人： SCHERING CORPORATION

发明人： REICHARD, Gregory, A. ,  ASLANIAN, Robert, G. ,  ALAIMO, Cheryl, L. ,  KIRKUP, Michael, P. ,  LUPO, Andrew ,  MANGIARACINA, Pietro ,  MCCORMICK, Kevin, D. ,  PIWINSKI, John, J. ,  SHANKAR, Bandarpalle ,  SHIH, Neng-Yang ,  SPITLER, James, M. ,  TING, Pauline, C. ,  GANGULY, Ashit ,  CARRUTHERS, Nicholas, I.

IPC分类号： C07D295 ,  A61K31 ,  A61P1 ,  A61P11 ,  A61P25 ,  A61P29 ,  A61P43 ,  C07D205 ,  C07D207 ,  C07D211 ,  C07D333 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D451

CPC分类号： C07D295/185 ,  C07D211/52 ,  C07D211/58 ,  C07D211/76 ,  C07D295/13 ,  C07D333/22 ,  C07D401/04 ,  C07D401/06 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： Compound represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3; b, d and e are independently 0, 1 or 2; R is H, C1-6 alkyl, -OH or C2-C6 hydroxyalkyl; A is an optionally substituted oxime, hydrazone or olefin; X is a bond, -C(O)-, -O-, -NR6-, -S(O)¿e?-, -N(R?6¿)C(O)-, -C(O)N(R6)-, -OC(O)NR6-, -OC(=S)NR?6-, -N(R6¿)C(=S)O-, -C(=NOR1)-, -S(O)¿2N(R?6)-, -N(R6)S(O)2-, -N(R6)C(O)O- or -OC(O)-; T is H, phthalimidyl, aryl, heterocycloalkyl, heteroaryl, cycloalkyl or bridged cycloalkyl; Q is -SR?6, -N(R6)(R7), -OR6¿, phenyl, naphthyl or heteroaryl; R?6a, R7a, R8a, R9a, R6 and R7¿ are H, C¿1-6? alkyl, C2-C6 hydroxyalkyl, C1-C6 alkoxy-C1-C6 alkyl, phenyl or benzyl; or R?6 and R7¿, together with the nitrogen to which they are attached, form a ring; R?9a is R6 or -OR6¿; Z is morpholinyl, optionally N-substituted piperazinyl, optionally substituted (a), or substituted (b); g is 0-3 and h is 1-4, provided the sum of h and g is 1-7; wherein aryl, heterocycloalkyl, heteroaryl, cycloalkyl and bridged cycloalkyl groups are optionally substituted; methods of treating asthma, cough, bronchospasm, inflammatory diseases, and gastrointestinal disorders with said compounds, and pharmaceutical compositions comprising said compounds are disclosed.