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公开(公告)号：EP0931146A1
公开(公告)日：1999-07-28
申请号：EP97945311.0
申请日：1997-09-26
CPC分类号： C07K14/47 , C07K14/43545 , C07K14/43581 , C07K16/18
摘要： The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.
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公开(公告)号：EP0942934A2
公开(公告)日：1999-09-22
申请号：EP97949790.0
申请日：1997-11-21
申请人： Sugen, Inc.
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K14/71
摘要： The specification describes isolated, purified, or enriched nucleic acid molecules which correspond to particular genes encoding kinases, and to fragments of such genes, as well as the polypeptides encoded by such nucleic acids and antibodies specific for those polypeptides. Also disclosed are methods using such nucleic acid molecules, polypeptides, or antibodies for isolating the full coding sequences for those kinases, for determining the expression patterns and levels for those genes, for screening for agents which modulate the activity of one of the kinases, and for diagnosing or treating a disease associated with one of the kinases.
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公开(公告)号：EP1294901A2
公开(公告)日：2003-03-26
申请号：EP01933003.4
申请日：2001-05-04
发明人： PLOWMAN, Gregory, D. , WHYTE, David , SUDARSANAM, Sucha , MANNING, Gerard , CAENEPEEL, Sean , PAYNE, Vilia
CPC分类号： C12N9/6424 , C12Q1/37 , G01N2333/96433
摘要： The present invention relates to protease polypeptides, nucleotide sequences encoding the protease polypeptides, as well as various products and methods useful for the diagnosis and treatment of various protease-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.
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公开(公告)号：EP1180151A2
公开(公告)日：2002-02-20
申请号：EP00936414.2
申请日：2000-05-26
申请人： Sugen, Inc.
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions.
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公开(公告)号：EP0868519B1
公开(公告)日：2006-01-11
申请号：EP96940870.7
申请日：1996-11-25
申请人： Sugen, Inc.
CPC分类号： C07K16/40 , A01K2217/05 , A61K48/00 , C12N9/12 , C12N9/1205 , C12N2799/027
摘要： The present invention relates to AUR-1 and/or AUR-2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR-1 and/or AUR-2 related diseases or conditions characterized by an abnormal interaction between an AUR-1 and/or AUR-2 polypeptide and an AUR-1 and/or AUR-2 binding partner.
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6.发明授权
公开(公告)号：EP1051500B1
公开(公告)日：2005-08-17
申请号：EP99905450.5
申请日：1999-01-21
申请人： Sugen, Inc.
CPC分类号： C12N9/1205 , A01K2217/05 , A61K38/00 , C12Q1/485 , G01N2333/9121 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to AUR1 and/or AUR2 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for AUR1 and/or AUR2 related diseases or conditions characterized by an abnormal interaction between an AUR1 and/or AUR2 polypeptide and an AUR1 and/or AUR2 binding partner.
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公开(公告)号：EP1299525A2
公开(公告)日：2003-04-09
申请号：EP00988227.5
申请日：2000-12-21
申请人： Sugen, Inc.
发明人： PLOWMAN, Gregory, D. , MARTINEZ, Ricardo , WHYTE, David , MANNING, Gerard , SUDARSANAM, Sucha , HILL, Ronald, J. , FLANAGAN, Peter
IPC分类号： C12N9/00
摘要： The present invention relates to phosphatase polypeptides, nucleotide sequences encoding the phosphatase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various phosphatase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the MAP kinase hosphatase PTP's and STP's have been identified and their protein structure predicted.
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8.发明公开
公开(公告)号：EP1240194A2
公开(公告)日：2002-09-18
申请号：EP00982200.8
申请日：2000-11-22
申请人： Sugen, Inc.
发明人： PLOWMAN, Gregory, D. , WHYTE, David , MANNING, Gerard,Sugen, Inc. , SUDARSANAM, Sucha,Sugen, Inc. , MARTINEZ, Ricardo , FLANAGAN, Peter , CLARY, Douglas,Sugen, Inc.
IPC分类号： C07K14/47
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the PTK's and STK's have been identified and their protein structure predicted.
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9.发明公开PROTEIN PHOSPHATASES AND DIAGNOSIS AND TREATMENT OF PHOSPHATASE-RELATED DISORDERS 审中-公开蛋白磷酸酶的诊断和磷酸酶相关的投诉处理情况
公开(公告)号：EP1212433A2
公开(公告)日：2002-06-12
申请号：EP00957413.8
申请日：2000-08-11
申请人： Sugen, Inc.
发明人： PLOWMAN, Gregory, D. , MARTINEZ, Ricardo , WHYTE, David , HILL, Ron , FLANAGAN, Peter , LIOUBIN, Mario
CPC分类号： A61K38/46 , A61K45/00 , C07K16/40 , C12N5/10 , C12N9/16 , C12N15/02 , C12N15/09 , C12Q1/02 , C12Q1/42 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
摘要： The present invention concerns polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to the polypeptides, assays utilizing the polypeptides, and methods relating to all of the foregoing. Preferably, the polypeptides of the present invention are phosphatases. Through the use of a 'motif extraction' bioinformatics script, additional mammalian members of the phosphatase family are herein presented. These phosphatases include MKP-like proteins, a CDC14-like protein, a PTEN-like protein, and myotubularin (MTM)-like proteins. Classification of proteins as new members of established families has proven highly accurate not only in predicting motifs present in the remaining non-catalytic portion of each protein, but also in their regulation, substrates, and signaling pathways.
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公开(公告)号：EP0942934B1
公开(公告)日：2008-01-02
申请号：EP97949790.6
申请日：1997-11-21
申请人： Sugen, Inc.
IPC分类号： C07K14/71
CPC分类号： C12N9/1205 , A01K2217/05 , A61K48/00 , C07K14/71
摘要： The specification describes isolated, purified, or enriched nucleic acid molecules which correspond to particular genes encoding kinases, and to fragments of such genes, as well as the polypeptides encoded by such nucleic acids and antibodies specific for those polypeptides. Also disclosed are methods using such nucleic acid molecules, polypeptides, or antibodies for isolating the full coding sequences for those kinases, for determining the expression patterns and levels for those genes, for screening for agents which modulate the activity of one of the kinases, and for diagnosing or treating a disease associated with one of the kinases.
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