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公开(公告)号：EP2352816A1
公开(公告)日：2011-08-10
申请号：EP09824313.2
申请日：2009-11-06
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
摘要翻译： 描述了能够成功移植鼠胸腺并分化成成熟的人T和NK细胞的人祖细胞T细胞。 人祖细胞T细胞具有表型CD34 + CD7 + CD1a-CD5-或CD34 + CD7 + CD1a-CD5 +，并且通过与表达Notch受体的细胞共培养来源于人造血干细胞，胚胎干细胞和诱导的多能干细胞 配体（OP9-DL1或OP9-DL4）。 这样的细胞可用于各种应用，包括免疫重建，免疫缺陷的治疗和用于基因治疗的基因的载体。
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公开(公告)号：EP2352816B1
公开(公告)日：2015-06-24
申请号：EP09824313.2
申请日：2009-11-06
IPC分类号： A61K35/12 , C12N5/0789 , C12N5/0775 , C12N5/077 , G01N33/50 , C12N5/0783
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
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