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公开(公告)号：EP2844744A2
公开(公告)日：2015-03-11
申请号：EP13713247.8
申请日：2013-02-21
发明人： BRODIE, Chaya , SLAVIN, Shimon
IPC分类号： C12N5/079 , A61P25/00 , A61P25/16 , C12N15/113
CPC分类号： A61K35/30 , A61K35/28 , A61K35/50 , A61K35/51 , C12N5/0622 , C12N15/113 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/41 , C12N2501/65 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/025 , C12N2506/1353 , C12N2506/1369 , C12N2506/1384 , C12N2506/1392 , C12N2510/00 , C12Q1/6876 , C12Q2600/178
摘要： A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous mi RNA in mesenchymal stem cells (MSCs) and/or down-regulating a level of at least one mi RNA using a polynucleotide agent that hybridizes to the mi RNA, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells generated thereby and uses thereof are also provided.
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公开(公告)号：EP2804944A1
公开(公告)日：2014-11-26
申请号：EP13705262.7
申请日：2013-01-14
发明人： ZIPORI, Dov , SHOSHANI, Ofer
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N5/0663 , C12N13/00 , C12N2500/02 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/1353 , C12N2510/00
摘要： The invention relates to induction of reprogramming of somatic cells, by methods which require mild growth conditions. Disclosed are methods of inducing dedifferentiation of mesenchymal stromal cell (MSC), by seeding or incubating mesenchymal stromal cells (MSCs) at low density, and without introduction or expression of exogenous genes in the cells.
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3.发明公开
公开(公告)号：EP2502985A4
公开(公告)日：2013-04-24
申请号：EP10831541
申请日：2010-11-16
IPC分类号： C12N5/07 , A61K33/14 , A61K33/40 , A61K36/258 , A61K38/16 , A61K38/17 , A61K45/00 , A61P1/02 , A61P43/00 , C12N5/077
CPC分类号： A61K31/00 , A61K33/14 , A61K33/40 , A61K36/258 , A61K38/1709 , C12N5/0654 , C12N5/0664 , C12N2500/05 , C12N2501/00 , C12N2501/415 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , A61K2300/00
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公开(公告)号：EP2992088A2
公开(公告)日：2016-03-09
申请号：EP14780560.0
申请日：2014-04-30
申请人： Katholieke Universiteit Leuven , Roobrouck, Valerie , Delforge, Michel , Verfaillie, Catherine, M.
IPC分类号： C12N5/074 , A61K35/54 , A61K49/00 , G01N33/50 , A01K67/027
CPC分类号： A61K35/545 , A61K49/0004 , C12N5/0607 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , G01N33/5044
摘要： The invention provides methods for treating myelodysplastic syndrome (MDS). The invention is generally directed to reducing certain overt symptoms and disease-causing biological events in MDS by administering certain cells to a subject having MDS. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to affect these events. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency for affecting these events.
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5.发明授权
公开(公告)号：EP2502985B1
公开(公告)日：2015-04-29
申请号：EP10831541.7
申请日：2010-11-16
IPC分类号： C12N5/07 , A61K33/14 , A61K33/40 , A61K38/16 , A61K45/00 , A61P1/02 , A61P43/00 , C12N5/077 , A61K38/17 , A61K36/258
CPC分类号： A61K31/00 , A61K33/14 , A61K33/40 , A61K36/258 , A61K38/1709 , C12N5/0654 , C12N5/0664 , C12N2500/05 , C12N2501/00 , C12N2501/415 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , A61K2300/00
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公开(公告)号：EP2352816A4
公开(公告)日：2012-12-12
申请号：EP09824313
申请日：2009-11-06
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
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公开(公告)号：EP3401393A1
公开(公告)日：2018-11-14
申请号：EP18180526.8
申请日：2013-02-21
发明人： BRODIE, Chaya
IPC分类号： C12N5/079 , A61P25/00 , A61P25/16 , C12N15/113
CPC分类号： A61K35/30 , A61K35/28 , A61K35/50 , A61K35/51 , C12N5/0622 , C12N15/113 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/41 , C12N2501/65 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/025 , C12N2506/1353 , C12N2506/1369 , C12N2506/1384 , C12N2506/1392 , C12N2510/00 , C12Q1/6876 , C12Q2600/178
摘要： A method of generating astrocytes is disclosed, the method comprising up-regulating miR-101 and down-regulating miR-138 using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs). Isolated cell populations and uses thereof are also disclosed.
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公开(公告)号：EP2985343A1
公开(公告)日：2016-02-17
申请号：EP14002800.2
申请日：2014-08-11
IPC分类号： C12N5/0789
CPC分类号： C12N5/0062 , C12N5/0647 , C12N2502/1171 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2513/00 , C12N2531/00
摘要： The present invention relates to a three-dimensional (3D) model of a hematopoietic stem and progenitor cell (HSPC) niche, that comprises the coculture of human HSPC and human mesenchymal stromal cells in a defined 3D environment and thereby procures vital stem cell functions.
摘要翻译： 本发明涉及造血干细胞和祖细胞（HSPC）利基的三维（3D）模型，其包括在定义的3D环境中人HSPC和人间质基质细胞的共培养，从而获得重要的干细胞功能。
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公开(公告)号：EP2352816B1
公开(公告)日：2015-06-24
申请号：EP09824313.2
申请日：2009-11-06
IPC分类号： A61K35/12 , C12N5/0789 , C12N5/0775 , C12N5/077 , G01N33/50 , C12N5/0783
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b\ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
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10.发明公开METHOD FOR PRODUCING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION, COMPOSITION CONTAINING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION PRODUCED THEREBY, AND METHOD FOR TRANSPLANTING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION 审中-公开方法用于生产具有领导移植生殖器官系统与领导生殖器官SYSTEM FOR移植生殖器官系统移植和方法顺序生成组成，并具领导移植
公开(公告)号：EP2674484A4
公开(公告)日：2015-01-14
申请号：EP11858349
申请日：2011-07-27
发明人： TOYOSHIMA KOH-EI , TSUJI TAKASHI
CPC分类号： C12N5/0697 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L2430/18 , C12N5/0627 , C12N5/0633 , C12N2502/13 , C12N2502/1376 , C12N2533/54
摘要： The purpose of the present invention is to provide a method for producing a regenerative organ primordium for transplantation, said regenerative organ primordium for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. Provided is a method for producing a regenerative organ primordium provided with a guide for transplantation, said method comprising: a step for preparing a regenerative organ primordium by tightly contacting a first cell mass, which substantially consists of mesenchymal cells, with a second cell mass, which substantially consists of epithelial cells, and culturing these cell masses within a supporting medium; and a step for inserting the guide into the regenerative organ primordium.
摘要翻译： 本发明的目的是提供一种生产用于移植的再生器官原基提供一种方法，所述移植后移植确保连续性与接受方和促进移植程序再生器官原基。 提供了一种用于制造设置有用于移植的引导再生器官原基的方法，所述方法包括：通过紧密接触的第一细胞集合体，用于制备再生器官原基步骤基本上间充质细胞的besteht，与第2细胞集合体， 基本上besteht支撑介质内上皮细胞，和培养细胞合成群众; 和用于插入引导到再生器官原基的步骤。
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