公开(公告)号：EP2108043A1

公开(公告)日：2009-10-14

申请号：EP08701716.6

申请日：2008-01-18

申请人： Suomen Punainen Risti, Veripalvelu ,  Glykos Finland Ltd

发明人： LAINE, Jarmo ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne ,  SAARINEN, Juhani ,  TIITINEN, Sari ,  IMPOLA, Ulla ,  MIKKOLA, Milla ,  VALMU, Leena ,  TIITTANEN, Minna

IPC分类号： C12N5/06 ,  C12N5/08

CPC分类号： C12N5/0606 ,  C12N5/0647 ,  C12N5/0663 ,  C12N5/0665 ,  C12N2501/59 ,  C12N2501/90

摘要： The present invention provides methods and mate rials to modulate and grow stem cells by contacting stem cells with a binder recognizing te rminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.

公开(公告)号：EP2315828A2

公开(公告)日：2011-05-04

申请号：EP09784152.2

申请日：2009-07-13

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： IMPOLA, Ulla ,  TIITTANEN, Minna ,  MIKKOLA, Milla ,  PARTANEN, Jukka ,  NATUNEN, Jari ,  SATOMAA, Tero ,  SAARINEN, Juhani

IPC分类号： C12N5/0735 ,  C07K14/47

CPC分类号： C12N15/873 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2533/50

摘要： The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.

公开(公告)号：EP2047257A1

公开(公告)日：2009-04-15

申请号：EP07788780.0

申请日：2007-06-29

申请人： Suomen Punainen Risti, Veripalvelu ,  Glykos Finland Oy

发明人： LAINE, Jarmo ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  SAARINEN, Juhani ,  JAATINEN, Taina ,  MIKKOLA, Milla ,  NATUNEN, Suvi

IPC分类号： G01N33/50 ,  C12N5/06

CPC分类号： G01N33/6848 ,  C08B37/0006 ,  C08B37/006 ,  C12N5/0606 ,  G01N33/56966 ,  G01N2400/10

摘要： The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.

摘要翻译： 本发明描述了来自人胚胎干细胞的聚糖，糖类的新型组合物，尤其是具有特定单糖组成和聚糖结构的糖类的新型亚组合物。 本发明还涉及修饰糖类和糖类和修饰糖类分析的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。 优选通过分析方法分析糖类，所述方法能够同时检测可重复和定量的多种单独的聚糖结构。 该配置文件的最优选类型是质谱配置文件。 本发明具体揭示了新颖的靶结构并且特别针对开发识别结构的试剂。

公开(公告)号：EP1945676A1

公开(公告)日：2008-07-23

申请号：EP06808024.1

申请日：2006-11-08

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： LAINE, Jarmo ,  SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne ,  SAARINEN, Juhani ,  JAATINEN, Taina ,  IMPOLA, Ulla ,  MIKKOLA, Milla

IPC分类号： C08B37/00 ,  C07H13/04 ,  G01N33/50 ,  C12N5/06

CPC分类号： G01N33/66 ,  C07H13/04 ,  C08B37/006 ,  G01N2400/10

摘要： The present invention discloses a method of evaluating the status of a stem cell preparation comprising the step of detecting the presence of a glycan structure or a group of glycan structures in said preparation. The detection step can be performed by the use of a lectin specific to a glycan structure of interest.

公开(公告)号：EP1904532A2

公开(公告)日：2008-04-02

申请号：EP06764561.4

申请日：2006-07-11

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： SATOMAA, Tero ,  NATUNEN, Jari ,  LAINE, Jarmo ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne ,  SAARINEN, Juhani ,  JAATINEN, Taina ,  IMPOLA, Ulla ,  MIKKOLA, Milla ,  HEMMORANTA, Heidi

IPC分类号： C08B37/00 ,  C07H13/04 ,  G01N33/50 ,  C12N5/06

CPC分类号： C12N5/0665 ,  C08B37/00 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2501/59 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/57469 ,  G01N33/577 ,  G01N2400/10 ,  G01N2400/38 ,  G01N2560/00

摘要： The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.

摘要翻译： 本发明描述了用于从人多能干细胞产生新的糖链聚糖组合物的方法。 本发明还涉及修饰糖类和糖类和修饰糖类分析的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。