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公开(公告)号：EP1326707A2
公开(公告)日：2003-07-16
申请号：EP01968731.8
申请日：2001-09-06
申请人： SurModics, Inc.
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00385 , B01J2219/00432 , B01J2219/00439 , B01J2219/00441 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： The invention provides a method for generating arrays with a variety of densities, in particular, high density arrays Generally, the method includes a printing step and an illumination step. In the printing step, a predetermined volume of a reagent solution containing receptor molecules is applied to a solid support in a desired pattern. In one embodiment, the receptor molecule is derivatized with a photoreactive agent. In an alternate embodiment, the solid support includes a photoreactive agent. In a preferred embodiment, the receptor molecule is a nucleic acid. In the illumination step, the photoreactive groups are irradiated to immobilize the receptor molecule to the solid support. In one embodiment, a mask having the same center to center distance (e.g., 'pitch) as the printed spots, but a smaller diameters, is placed over the printed pattern and illuminated. Preferably the mask illuminates a spot having a smaller diameter than the printed spots. Thus, according to the invention, immobilized reagent spot has a smaller diameter than the original printed spot. In an alternate embodiment, the illumination step can be carried out using mirrored laser technology. If desired, the application and illumination of offset spots can be repeated to form a high density array.
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公开(公告)号：EP1141385B1
公开(公告)日：2017-07-05
申请号：EP00903199.8
申请日：2000-01-10
申请人： SurModics, Inc.
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
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公开(公告)号：EP1064292B1
公开(公告)日：2006-09-20
申请号：EP99909547.4
申请日：1999-02-23
申请人： SurModics, Inc.
IPC分类号： C07H1/08 , C07H21/00 , G01N33/543 , C12Q1/68
CPC分类号： C07H21/00 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/543 , G01N33/68 , G01N33/6845 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974
摘要： A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its formation, and can thereafter be activated in order to attach the nucleic acid to another molecule, e.g., to the surface of a solid support. Also described is a method of preparing such a composition, and a method of using such a composition to attach the nucleic acid to another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.
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公开(公告)号：EP1434571A1
公开(公告)日：2004-07-07
申请号：EP02773669.3
申请日：2002-09-30
申请人： SurModics, Inc.
IPC分类号： A61K9/50 , A61K9/20 , A61K9/51 , A61L27/54 , A61L31/16 , A61L29/16 , A61K9/14 , A61K9/12 , B01J13/02 , A61K9/127 , A61K47/48 , A61K51/12 , A61K49/18
CPC分类号： B82Y5/00 , A61K9/1647 , A61K9/1652 , A61K9/2081 , A61K9/5073 , A61K9/5078 , A61K47/6927 , A61K47/6957 , A61K49/0002 , A61K49/1821 , A61K51/1244 , A61L27/54 , A61L29/18 , A61L31/18 , A61L2300/44 , A61L2300/604 , A61L2300/606 , A61L2300/622
摘要： Surface coatings including microparticles immobilized in a polymeric matrix on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and utilizing microparticles immobilized via a polymeric matrix.
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公开(公告)号：EP1147222B1
公开(公告)日：2006-11-22
申请号：EP00905741.5
申请日：2000-01-27
申请人： SurModics, Inc.
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , Y10S436/807 , Y10S436/809 , Y10S977/849
摘要： A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.
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公开(公告)号：EP1147222A1
公开(公告)日：2001-10-24
申请号：EP00905741.5
申请日：2000-01-27
申请人： SurModics, Inc.
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , Y10S436/807 , Y10S436/809 , Y10S977/849
摘要： A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.
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公开(公告)号：EP1141385A2
公开(公告)日：2001-10-10
申请号：EP00903199.8
申请日：2000-01-10
申请人： SurModics, Inc.
IPC分类号： C12Q1/68
CPC分类号： B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
摘要： Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
摘要翻译： 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活化载玻片。
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公开(公告)号：EP1064292A1
公开(公告)日：2001-01-03
申请号：EP99909547.4
申请日：1999-02-23
申请人： SurModics, Inc.
IPC分类号： C07H1/08 , C07H21/00 , G01N33/543 , C12Q1/68
CPC分类号： C07H21/00 , A61L27/14 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10 , A61L33/0011 , A61L33/0047 , C12N11/08 , C12Q1/56 , C12Q1/6834 , G01N33/543 , G01N33/68 , G01N33/6845 , G01N33/6854 , G01N2333/78 , G01N2333/8128 , G01N2333/815 , G01N2333/974
摘要： A photoactivatable nucleic acid derivative composition in which one or more photoreactive group(s) are bound to a natural or synthetic nucleic acid. The photoreactive groups can be bound to the nucleic acid before, during or after its formation, and can thereafter be activated in order to attach the nucleic acid to another molecule, e.g., to the surface of a solid support. Also described is a method of preparing such a composition, and a method of using such a composition to attach the nucleic acid to another molecule, such as that provided by the surface of a substrate used to prepare a nucleic acid chip by photolithographic techniques.
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公开(公告)号：EP1432989B1
公开(公告)日：2009-12-02
申请号：EP02800906.6
申请日：2002-10-04
申请人： SurModics, Inc.
IPC分类号： G01N33/543 , C12Q1/68 , B01J19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00725 , B82Y5/00 , B82Y10/00 , C12Q1/6837 , G01N33/54366 , Y10S530/81 , Y10S530/811 , Y10S530/815 , Y10S530/816 , C12Q2563/149
摘要： Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.
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公开(公告)号：EP1069916B1
公开(公告)日：2006-05-10
申请号：EP99909955.9
申请日：1999-03-11
申请人： SurModics, Inc.
发明人： GUIRE, Patrick, E. , ANDERSON, Aron, B. , AMOS, Richard, A. , EVERSON, Terrence, P. , DUQUETTE, Peter H.
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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