公开(公告)号：EP1309360B1

公开(公告)日：2006-04-19

申请号：EP01959785.5

申请日：2001-07-09

申请人： SurModics, Inc.

发明人： CHUDZIK, Stephen, J. ,  EVERSON, Terrence, P. ,  AMOS, Richard, A.

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10

CPC分类号： A61L31/145 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  Y10S514/944 ,  C08L71/02

摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.

公开(公告)号：EP1131167A1

公开(公告)日：2001-09-12

申请号：EP99949672.2

申请日：1999-09-22

申请人： SurModics, Inc.

发明人： SWAN, Dale, G. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P. ,  CHUDZIK, Stephen, J. ,  CHAPPA, Ralph, A. ,  STUCKE, Sean, M. ,  DUQUETTE, Peter, H.

IPC分类号： B05D3/06 ,  B05D1/00 ,  C07C309/42

CPC分类号： C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

摘要： A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

公开(公告)号：EP1069916B1

公开(公告)日：2006-05-10

申请号：EP99909955.9

申请日：1999-03-11

申请人： SurModics, Inc.

发明人： GUIRE, Patrick, E. ,  ANDERSON, Aron, B. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P. ,  DUQUETTE, Peter H.

IPC分类号： A61K47/48 ,  A61L27/00

CPC分类号： A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

公开(公告)号：EP1003561B1

公开(公告)日：2005-05-11

申请号：EP98944435.1

申请日：1998-08-11

申请人： SurModics, Inc.

发明人： CLAPPER, David, L. ,  SWANSON, Melvin, J. ,  HU, Sheau-Ping ,  AMOS, Richard, A. ,  EVERSON, Terrence, P.

IPC分类号： A61L2/00

CPC分类号： G01N33/6845 ,  A61L27/14 ,  A61L27/34 ,  A61L29/04 ,  A61L29/085 ,  A61L31/04 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0047 ,  C08J7/12 ,  C12N11/08 ,  C12Q1/56 ,  C12Q1/6834 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/68 ,  G01N33/6854 ,  G01N2333/78 ,  G01N2333/8128 ,  G01N2333/815 ,  G01N2333/974 ,  Y10S530/815 ,  Y10S530/816

摘要： A polybifunctional reagent having a polymeric backbone, one or more pendent photoreactive moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought into contact with the surface of a previously formed biomaterial and activated to form a coating. The pendent bioactive groups function by promoting the attachment of specific molecules or cells to the bulk material or coated surface. Bioactive groups can include proteins, peptides, carbohydrates, nucleic acids and other molecules that are capable of binding noncovalently to specific and complimentary portions of molecules or cells.

公开(公告)号：EP1131167B1

公开(公告)日：2004-07-07

申请号：EP99949672.2

申请日：1999-09-22

申请人： SurModics, Inc.

发明人： SWAN, Dale, G. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P. ,  CHUDZIK, Stephen, J. ,  CHAPPA, Ralph, A. ,  STUCKE, Sean, M. ,  DUQUETTE, Peter, H.

IPC分类号： B05D3/06 ,  B05D1/00 ,  C07C309/42

CPC分类号： C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

公开(公告)号：EP1085918B1

公开(公告)日：2003-11-19

申请号：EP99927236.2

申请日：1999-06-04

申请人： Surmodics Inc.

发明人： ANDERSON, Aron, B. ,  CHAPPA, Ralph, A. ,  EVERSON, Terrence, P.

IPC分类号： A61L27/40 ,  A61L31/12 ,  A61L33/00 ,  A61L29/12

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  Y10S623/901 ,  C08L83/04

摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

公开(公告)号：EP0862624B1

公开(公告)日：2004-05-19

申请号：EP96937893.4

申请日：1996-10-31

申请人： SurModics, Inc.

发明人： SWAN, Dale, G. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P.

IPC分类号： C12N11/00 ,  C12N11/02 ,  C12N11/08 ,  C12N11/06 ,  G01N33/549 ,  C07K17/06 ,  C07H1/00 ,  C07C49/76 ,  C07C43/30 ,  C07D237/00 ,  C07D265/00

CPC分类号： C07D295/112 ,  C07C45/63 ,  C07C225/16 ,  C07C309/14 ,  C07K17/06 ,  G01N33/54353 ,  Y10S530/81 ,  Y10S530/816 ,  C07C49/813

公开(公告)号：EP1085918A1

公开(公告)日：2001-03-28

申请号：EP99927236.2

申请日：1999-06-04

申请人： Surmodics Inc.

发明人： ANDERSON, Aron, B. ,  CHAPPA, Ralph, A. ,  EVERSON, Terrence, P.

IPC分类号： A61L27/00 ,  A61L31/00 ,  A61L33/00 ,  A61L29/00

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  Y10S623/901 ,  C08L83/04

摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

公开(公告)号：EP1069916A2

公开(公告)日：2001-01-24

申请号：EP99909955.9

申请日：1999-03-11

申请人： SurModics, Inc.

发明人： GUIRE, Patrick, E. ,  ANDERSON, Aron, B. ,  AMOS, Richard, A. ,  EVERSON, Terrence, P.

IPC分类号： A61K47/48 ,  A61L27/00

CPC分类号： A61K31/12 ,  A61K31/74 ,  A61K47/6957 ,  A61L27/227 ,  A61L27/34 ,  A61L27/507 ,  A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0082

摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

公开(公告)号：EP1309360A2

公开(公告)日：2003-05-14

申请号：EP01959785.5

申请日：2001-07-09

申请人： SurModics, Inc.

发明人： CHUDZIK, Stephen, J. ,  EVERSON, Terrence, P. ,  AMOS, Richard, A.

IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10

CPC分类号： A61L31/145 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  Y10S514/944 ,  C08L71/02

摘要： A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.