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公开(公告)号：EP2104755A2
公开(公告)日：2009-09-30
申请号：EP07854450.9
申请日：2007-10-26
发明人： BERGH, H., Sam , WELLS, Jason , WONG, Victor , GALLIPEO, John , VAN ERDEN, Lynn , VOLPE, Anthony, F. , MAAG, Jeffrey
IPC分类号： C40B30/00
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00389 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00601 , B01J2219/00689 , B01J2219/00704 , B01J2219/00736 , B01J2219/00747 , C40B60/12
摘要： The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
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公开(公告)号：EP1080435A1
公开(公告)日：2001-03-07
申请号：EP99955064.3
申请日：1999-10-19
发明人： LACY, Steven, D. , MCFARLAND, Eric, W. , SAFIR, Adam, L. , TURNER, Stephen, J. , VAN ERDEN, Lynn , WANG, Pei
IPC分类号： G06F17/50
CPC分类号： C40B50/02 , B01J19/0046 , B01J2219/00477 , B01J2219/00479 , B01J2219/00495 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/007 , C40B60/14
摘要： Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.
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公开(公告)号：EP1578523A1
公开(公告)日：2005-09-28
申请号：EP03768657.3
申请日：2003-11-04
发明人： GOH, Christopher , HALL, Keith, Anthony , BOUSSIE, Thomas, R. , MURPHY, Vince , FRANK, Trevor, G. , CHANDLER, William, H. , VAN ERDEN, Lynn
CPC分类号： B01J3/04 , B01J19/0046 , B01J2219/00283 , B01J2219/00315 , B01J2219/00353 , B01J2219/00477 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00601 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , B01J2219/00738 , C40B40/14 , C40B50/08 , C40B60/14 , Y10T436/2575
摘要： An apparatus and method for injection of one or more chemical components into a reaction chamber are disclosed. The apparatus includes a reaction chamber for receiving one or more libraries (26) in a fixed position relative to the chamber and configured to form a sealed enclosure. An injection manifold (28) is located within the reaction chamber and selectively movable relative to the libraries (26). The injection manifold (28) is configured for receiving at least one fluid transfer line coupled to an external source for injection of one or more chemical components into the reaction chamber.
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公开(公告)号：EP1080435B1
公开(公告)日：2002-02-27
申请号：EP99955064.3
申请日：1999-10-19
发明人： LACY, Steven, D. , MCFARLAND, Eric, W. , SAFIR, Adam, L. , TURNER, Stephen, J. , VAN ERDEN, Lynn , WANG, Pei
IPC分类号： G06F17/50
CPC分类号： C40B50/02 , B01J19/0046 , B01J2219/00477 , B01J2219/00479 , B01J2219/00495 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/007 , C40B60/14
摘要： Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.
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公开(公告)号：EP1069942B1
公开(公告)日：2003-05-28
申请号：EP99942147.2
申请日：1999-08-12
发明人： TURNER, Howard , DALES, G., Cameron , VAN ERDEN, Lynn , VAN BEEK, Johannes, A., M. , HAJDUK, Damian, A. , NIELSEN, Ralph, B. , MANSKY, Paul , MATSIEV, Leonid , WANG, Pei , McFARLAND, Eric
IPC分类号： B01J19/00
CPC分类号： G01N21/253 , B01F13/065 , B01F13/08 , B01F15/00207 , B01F15/00357 , B01F15/00396 , B01F15/00454 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , Y10T436/11
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号：EP1069942A1
公开(公告)日：2001-01-24
申请号：EP99942147.2
申请日：1999-08-12
发明人： TURNER, Howard , DALES, G., Cameron , VAN ERDEN, Lynn , VAN BEEK, Johannes, A., M. , HAJDUK, Damian, A. , NIELSEN, Ralph, B. , MANSKY, Paul , MATSIEV, Leonid , WANG, Pei , McFARLAND, Eric
IPC分类号： B01J19/00
CPC分类号： G01N21/253 , B01F13/065 , B01F13/08 , B01F15/00207 , B01F15/00357 , B01F15/00396 , B01F15/00454 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , Y10T436/11
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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