摘要:
The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.
摘要:
A light irradiation multi-sample parallel reaction device comprises: a base (1), a support disc (2) horizontally fixed and mounted above the base (1), a top disc (3) mounted above the support disc (2), a rotating disc (4) rotatably mounted below the support disc (2), and a plurality of reaction flasks (5), wherein a plurality of light transmission holes are circumferentially formed in the support disc (2); the plurality of reaction flasks (5) are placed on the light transmission holes in a one-to-one correspondence; a plurality of reaction flask through-holes for the reaction flasks (5) to pass through are formed in the top disc (3); a plurality of sets of stirrers (7) corresponding to the reaction flasks (5) are mounted between the top disc (3) and the support disc (2), and used for stirring liquids in the reaction flasks (5); the rotating disc (4) is arranged coaxially with the support disc (2); and a plurality of light sources (9) are arranged on an upper surface of the rotating disc (4). The device enables the irradiation intensity of light entering solutions to be consistent, improving experimental accuracy.
摘要:
Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
摘要:
A light irradiation multi-sample parallel reaction device comprises: a base (1), a support disc (2) horizontally fixed and mounted above the base (1), a top disc (3) mounted above the support disc (2), a rotating disc (4) rotatably mounted below the support disc (2), and a plurality of reaction flasks (5), wherein a plurality of light transmission holes are circumferentially formed in the support disc (2); the plurality of reaction flasks (5) are placed on the light transmission holes in a one-to-one correspondence; a plurality of reaction flask through-holes for the reaction flasks (5) to pass through are formed in the top disc (3); a plurality of sets of stirrers (7) corresponding to the reaction flasks (5) are mounted between the top disc (3) and the support disc (2), and used for stirring liquids in the reaction flasks (5); the rotating disc (4) is arranged coaxially with the support disc (2); and a plurality of light sources (9) are arranged on an upper surface of the rotating disc (4). The device enables the irradiation intensity of light entering solutions to be consistent, improving experimental accuracy.
摘要:
The present invention relates to a disposable module (100) for use in a device (300) for synthesizing radiopharmaceutical products starting from chemical reactants, said disposable module (100) comprising: a support plate (101) comprising rigid connection means (114) to at least one flask of chemical reactants (102, 103, 104, 105) in solution in a solvent, and a reactor (106); interface means (115) for interfacing with a fixed module of said synthesis device (300), in contact with or integrated into said support plate (101), said interface means comprising at least one valve (V1-V8) and/or at least one fluid inlet (E1, E2) and/or at least one fluid outlet (O1, O2, O3); at least one duct (1-20) connected to said at least one valve (V1-V8) or to said at least one fluid inlet (E1, E2) or to said at least one fluid outlet (O1, O2, O3), characterized in that at least one of said ducts (1-20) is integrated into the body of the disposable module (100).
摘要:
The present invention provides a simplified method for the preparation of 18F-labelled compounds that is particularly suitable for automation. The method of the invention is specifically applicable where the 18F-labelled compound is prepared from a labelling precursor that comprises protecting groups and wherein the synthetic route to the final compound includes removal of these protecting groups by acid or alkaline hydrolysis. Also provided by the present invention is a cassette useful for carrying out the method of the invention in an automated manner.
摘要:
A preferred test system comprises a chemical and/or biological sample in a liquid test medium and contains both a liquid and a gas phase that simulates air- water gas exchanges It operates intermittently, with additions and eliminations of liquids being decoupled in time so that to make sure the medium is well mixed before eliminating any liquid; requirement for expensive fixed flow pumps, or accurate flow meters are eliminated while accurate measurement of fluxes between the chemical and/or biological sample, the liquid and the gas phase are possible by mass balance between added and eliminated liquids.
摘要:
A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.