公开(公告)号：EP2034996A2

公开(公告)日：2009-03-18

申请号：EP07809199.8

申请日：2007-05-25

申请人： Synta Pharmaceuticals Corporation

发明人： CHAE, Junghyun ,  DEMKO, Zachary ,  YING, Weiwen ,  DU, Zhenjian ,  FOLEY, Kevin ,  JAMES, David ,  PRZEWLOKA, Teresa ,  SONG, Minghu ,  ZHANG, Shijie ,  NG, Howard, P. ,  LI, Hao ,  CHIMMANAMADA, Dinesh, U. ,  ZHOU, Dan ,  QIN, Shuzhen ,  LEE, Chi-wan ,  SUN, Lijun ,  KOYA, Keizo

IPC分类号： A61K31/4196 ,  A61P31/00 ,  C07D249/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04 ,  C07D417/04

CPC分类号： C07D417/04 ,  C07D249/12 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04

摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

公开(公告)号：EP2155694A2

公开(公告)日：2010-02-24

申请号：EP08742209.3

申请日：2008-03-24

申请人： Synta Pharmaceuticals Corporation

发明人： LEE, Chi-wan ,  PRZEWLOKA, Teresa ,  YING, Weiwen ,  SONG, Minghu ,  DU, Zhenjian ,  FOLEY, Kevin ,  ZHOU, Dan ,  QIN, Shuzhen

IPC分类号： C07D239/10 ,  C07D249/12 ,  A61K31/4168 ,  A61K31/4196

CPC分类号： C07D239/36 ,  C07D209/40 ,  C07D239/10 ,  C07D239/20 ,  C07D253/06 ,  C07D403/04 ,  C07D405/04 ,  C07D487/04 ,  C07D491/048

摘要： The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.

摘要翻译： 本发明涉及根据式（IA）至（ID）的化合物和抑制Hsp90活性的组合物。 本发明进一步涉及在有需要的受试者中抑制Hsp90的活性的方法以及用于在有需要的受试者中预防或治疗过度增殖性病症例如癌症的方法，其包括向受试者施用本发明的化合物或 包含这种化合物的组合物。