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    METHODS OF INCREASING NATURAL KILLER CELL ACTIVITY FOR THERAPY
    7.
    发明公开
    METHODS OF INCREASING NATURAL KILLER CELL ACTIVITY FOR THERAPY 审中-公开
    方法以增加自然杀伤细胞活性的治疗

    公开(公告)号：EP1871350A1

    公开(公告)日：2008-01-02

    申请号：EP06750374.8

    申请日：2006-04-13

    申请人： Synta Pharmaceuticals Corporation

    发明人： BARSOUM, James ,  DU, Zhenjian

    IPC分类号： A61K31/16 ,  A61K31/165 ,  A61P37/04

    CPC分类号： A61K31/165 ,  A61K31/16 ,  Y02A50/402 ,  Y02A50/409 ,  Y02A50/415 ,  Y02A50/423 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/491 ,  Y02A50/492

    摘要： Methods of employing bis(thio-hydrazide amides) to increase NK cell activity in a subject in need thereof, e.g., a subject with an infection or an immunodeficiency, are provided such that the disorder is not cancer, a proliferative cell disorder, a non-infective heat shock protein 70 (Hsp70) responsive disorder, or a proteasome-inhibitor responsive disorder. Typically, a subject, e.g., a human, can be in need of increased NK cell activity has an immunodeficiency or is treated for an infection (e.g., a bacterial, viral, fungal, or parasite infection, or a combination thereof). The method includes administering to the subject an effective amount of a compound represented by Structural Formula I: Y is a covalent bond or an optionally substituted straight chained hydrocarbyl group, or, Y, taken together with both >C=Z groups to which it is bonded, is an optionally substituted aromatic group. R1-R4 are independently -H, an optionally substituted aliphatic group, an optionally substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R7-R8 are independently -H, an optionally substituted aliphatic group, or an optionally substituted aryl group. Z is O or S.