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    BIOADHESIVE HYDROGELS
    2.
    发明公开
    BIOADHESIVE HYDROGELS 有权
    生物黏附水凝胶

    公开(公告)号：EP2227262A2

    公开(公告)日：2010-09-15

    申请号：EP09700520.1

    申请日：2009-01-12

    申请人： Synthes GmbH ,  Drexel University

    发明人： KITA, Kristin, B. ,  SMITH, Nigel, G. ,  LOWMAN, Anthony, M. ,  FUSSELL, Garland, W.

    IPC分类号： A61L24/04

    CPC分类号： A61L24/043 ,  A61L2430/38

    摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.

    PHASE TRANSITIONING HYDROGELS
    6.
    发明公开
    PHASE TRANSITIONING HYDROGELS 有权
    相变水凝胶

    公开(公告)号：EP2285899A1

    公开(公告)日：2011-02-23

    申请号：EP09755692.2

    申请日：2009-05-27

    申请人： Synthes GmbH ,  Drexel University

    发明人： KITA, Kristin, B. ,  SMITH, Nigel, G. ,  LOWMAN, Anthony, M. ,  FUSSELL, Garland, W. ,  KEANE, Michael

    IPC分类号： C08L29/04 ,  A61L27/26 ,  A61L27/52 ,  C08L39/06 ,  C08L71/02 ,  C08K3/30

    CPC分类号： C08L29/04 ,  A61L27/26 ,  A61L27/52 ,  A61L2400/06 ,  C08K3/30 ,  C08L39/06 ,  C08L71/02 ,  C08L2666/14 ,  C08L2666/02

    摘要： A method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly( vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).

    摘要翻译： 形成最终浓度为约20％（w / w）至约65％（w / w）的聚（乙烯醇）和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物具有高于约30％（w / w）的总聚合物含量，高于配制前配制的前体聚合物溶液的总聚合物含量 该水凝胶组合物。 水凝胶组合物可进一步包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

    INFLATABLE INTERSPINOUS SPACER
    9.
    发明公开
    INFLATABLE INTERSPINOUS SPACER 有权
    充气INTERSPINÖSES距离元件

    公开(公告)号：EP2328493A1

    公开(公告)日：2011-06-08

    申请号：EP09759239.8

    申请日：2009-06-02

    申请人： Synthes GmbH

    发明人： SINGHATAT, Wamis ,  CHOW, David ,  SMITH, Nigel, G. ,  FUSSELL, Garland, W.

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7065 ,  A61B2017/00557

    摘要： The present invention is directed to an inflated interspinous spacer. The interspinous spacer is inserted into the interspinous space between adjacent spinous process in a deflated or unexpanded state, and is inflated or expanded with an injectable filler material. Upon inflation, the spacer preferably distracts the spinous processes and assumes a shape that retains the spacer in position and preferably mechanically locks with the spinous processes. The spacer includes two separate balloons configured to have different compressive modulus so that one balloon is softer and more deformable than the other balloon.