公开(公告)号：EP2219694B1

公开(公告)日：2015-01-21

申请号：EP08861332.8

申请日：2008-12-16

申请人： Synthes GmbH ,  Drexel University

发明人： KITA, Kristin ,  SMITH, Nigel, G. ,  LOWMAN, Anthony, M. ,  FUSSELL, Garland, W. ,  KEANE, Michael, F.

IPC分类号： A61L27/16 ,  A61L27/52

CPC分类号： A61L27/16

公开(公告)号：EP2278931A1

公开(公告)日：2011-02-02

申请号：EP09755789.6

申请日：2009-05-29

申请人： Synthes GmbH ,  Drexel University

发明人： SINGHATAT, Wamis ,  SMITH, Nigel, G. ,  FUSSELL, Garland, W. ,  KEANE, Michael, F. ,  LOWMAN, Anthony, M.

IPC分类号： A61B17/70 ,  A61F2/44

CPC分类号： A61F2/441 ,  A61F2002/30014 ,  A61F2002/3008 ,  A61F2002/30179 ,  A61F2002/30461 ,  A61F2002/30576 ,  A61F2002/30583 ,  A61F2002/30878 ,  A61F2002/4435

摘要： The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defect. After the inflatable device has been properly positioned, a filler material (11) is injected into the inflatable device to expand the device to a second expanded state. In the second expanded state, the inflatable annulus repair device seals the annulus defect, secures its position within the annulus defect to thereby limit or prevent migration, and applies a compression force to a captured portion of the annulus adjacent to the defect. The inflatable device is preferably filled with a liquid that solidifies into an elastic material within the device.

公开(公告)号：EP2219694A2

公开(公告)日：2010-08-25

申请号：EP08861332.8

申请日：2008-12-16

申请人： Synthes GmbH ,  Drexel University

发明人： KITA, Kristin ,  SMITH, Nigel, G. ,  LOWMAN, Anthony, M. ,  FUSSELL, Garland, W. ,  KEANE, Michael, F.

IPC分类号： A61L27/16

CPC分类号： A61L27/16

摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.

公开(公告)号：EP1917050A2

公开(公告)日：2008-05-07

申请号：EP06813765.2

申请日：2006-08-25

申请人： Synthes GmbH

发明人： MARCOLONGO, Michele, S. ,  LOWMAN, Anthony, M. ,  CLEMOW, Alastair, J., T. ,  KEANE, Michael, F. ,  VRESILOVIC, Edward

IPC分类号： A61L27/52 ,  A61F2/44

CPC分类号： A61L27/52 ,  A61F2/30767 ,  A61F2/441 ,  A61F2002/444

摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.

公开(公告)号：EP1917050B1

公开(公告)日：2010-04-14

申请号：EP06813765.2

申请日：2006-08-25

申请人： Synthes GmbH

发明人： MARCOLONGO, Michele, S. ,  LOWMAN, Anthony, M. ,  CLEMOW, Alastair, J., T. ,  KEANE, Michael, F. ,  VRESILOVIC, Edward

IPC分类号： A61L27/52 ,  A61F2/44

CPC分类号： A61L27/52 ,  A61F2/30767 ,  A61F2/441 ,  A61F2002/444

公开(公告)号：EP1865892A2

公开(公告)日：2007-12-19

申请号：EP06739924.6

申请日：2006-03-29

申请人： Synthes GmbH

发明人： VRESILOVIC, Edward ,  KEANE, Michael, F. ,  SCHAER, Thomas, P. Meadowset Farm and Apiary ,  ARTHUR, Amy ,  SINGHATAT, Wamis

IPC分类号： A61F2/46 ,  A61F2/44

CPC分类号： A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

摘要： An instrument (100) for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula (200) that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container (300) adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure (400) adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus (700) for determining the volume of prosthesis to be inserted includes a catheter or cannula (702) capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon (704) capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

公开(公告)号：EP1778134A1

公开(公告)日：2007-05-02

申请号：EP05776522.4

申请日：2005-07-27

申请人： Synthes USA ,  Synthes GmbH

发明人： VERSILOVIC, Edward ,  KEANE, Michael, F. ,  SCHAER, Thomas, P.

IPC分类号： A61F2/44 ,  A61F2/46

CPC分类号： A61F2/442 ,  A61B17/86 ,  A61F2/28 ,  A61F2/4611 ,  A61F2002/2839 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2230/0069 ,  A61F2230/0071

摘要： A degenerated nucleus pulposus located in a central core (110) region of an intervertebral disc (106) within the annulus fibrosus (108) is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel (116) through a vertebral body (102) adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure.