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1.发明公开METHOD FOR DETECTION OF BASIC PEPTIDE AND REAGENT FOR DETECTION OF BASIC PEPTIDE 有权检测方法基本肽和试剂基本肽的检测
公开(公告)号：EP2511707A1
公开(公告)日：2012-10-17
申请号：EP10836074.4
申请日：2010-12-10
IPC分类号： G01N33/68 , G01N21/82 , G01N33/52 , G01N33/536 , C07K14/47
CPC分类号： G01N33/74 , G01N21/82 , G01N33/536 , G01N33/6827 , G01N33/6872 , G01N33/86
摘要： The present invention provides a method for detection of a basic peptide by mixing a sample suspected to contain the basic peptide and a reagent containing denatured albumin and detecting turbidness due to a complex of the basic peptide and denatured albumin.
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2.发明授权METHOD FOR DETECTION OF BASIC PEPTIDE AND REAGENT FOR DETECTION OF BASIC PEPTIDE 有权检测方法基本肽和试剂基本肽的检测
公开(公告)号：EP2511707B1
公开(公告)日：2017-02-01
申请号：EP10836074.4
申请日：2010-12-10
IPC分类号： G01N33/68 , G01N21/82 , G01N33/52 , G01N33/536 , C07K14/47
CPC分类号： G01N33/74 , G01N21/82 , G01N33/536 , G01N33/6827 , G01N33/6872 , G01N33/86
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3.发明公开THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY 审中-公开治疗剂，间质性肺疾病的抗HMGB-1抗体含有
公开(公告)号：EP2123299A1
公开(公告)日：2009-11-25
申请号：EP08711356.9
申请日：2008-02-15
申请人： Kyushu University, National University Corporation , Kagoshima University , SHINO-TEST CORPORATION
IPC分类号： A61K39/395 , A61P11/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K16/18 , C07K2317/76
摘要： An objective of the present invention is to provide effective methods for treating interstitial pulmonary diseases including interstitial pneumonia such as IPF. The present invention suggests that antibodies against HMGB-1 are effective for treating pulmonary fibrosis. Thus, the present invention provides preparations which comprise an anti-HMGB-1 antibody for treating interstitial pulmonary diseases.
摘要翻译： 本发明的一个目的是提供一种用于治疗间质性肺疾病，包括间质性肺炎提供有效的方法：如IPF。 本发明提出做对抗HMGB-1抗体有效治疗肺纤维化。 因此，本发明提供了用于治疗间质性肺疾病的抗HMGB-1抗体的包含制剂。
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4.发明公开PERIODONTAL-DISEASE-SPECIFIC PEPTIDE, AND TREATMENT AND DIAGNOSIS OF PERIODONTAL DISEASE USING SAME 有权牙龈疾病的特异性肽和治疗牙龈疾病诊断THAT
公开(公告)号：EP2548888A1
公开(公告)日：2013-01-23
申请号：EP11756409.6
申请日：2011-03-17
申请人： Kagoshima University
发明人： MARUYAMA, Ikuro , HASHIGUCHI, Teruto , TANCHAROEN, Salunya , KAWAHARA, Ko-ichi , TANAKA, Kenji , LEE, Lyang-ja
IPC分类号： C07K14/78 , A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/02 , A61P37/06 , C07K7/08 , C07K16/28 , C12Q1/02 , G01N27/62 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/4741 , C07K16/18 , G01N33/564 , G01N2333/4742 , G01N2500/04 , G01N2800/18
摘要： The present invention provides an inhibitor of an autoimmune response to a periodontal bacterial enzymatic degradation product of keratin in gingival epithelium in a mammal having a periodontal bacterium in the oral cavity, containing a substance having affinity to the keratin or a degradation product thereof and/or a substance having affinity to an autoantibody to the degradation product, an agent for the prophylaxis and/or treatment of a periodontal disease and/or a complication thereof; a RANKL expression inhibitor containing a substance having affinity to the keratin or a degradation product thereof; and a method of diagnosing a periodontal disease including detecting the keratin or a degradation product thereof and/or an autoantibody thereto.
摘要翻译： 本发明提供了上，以在具有在口腔内牙周细菌哺乳动物牙龈上皮角蛋白的牙周病菌酶促降解产物的自身免疫应答抑制剂，含有一个具有物质亲和力的角蛋白或其降解产物和/或 具有与降解产物在自身抗体的亲和力的物质，对于牙周疾病和/或其并发症的预防和/或治疗剂; 一个RANKL表达抑制剂含有具有亲和力的角蛋白或它们的降解产物的物质; 和诊断牙周病包括：检测所述角蛋白或其降解产物和/或与其自身抗体的方法。
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5.发明公开AGENT FOR SUPPRESSING REJECTION IN ORGAN TRANSPLANTATION COMPRISING ANTI-HMGB-1 ANTIBODY 审中-公开手段排斥具有抗HMGB-1抗体器官移植还原
公开(公告)号：EP2123298A1
公开(公告)日：2009-11-25
申请号：EP08711350.2
申请日：2008-02-15
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/76
摘要： An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic islets. Thus, the present invention provides agents that comprise an anti-HMGB-1 antibody for suppressing rejection in organ transplantation.
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6.发明公开THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT 审中-公开与抗体特异性结合人HMGB-1作为有效治疗剂
公开(公告)号：EP2123297A1
公开(公告)日：2009-11-25
申请号：EP08711330.4
申请日：2008-02-15
发明人： ANDO, Yukio , MARUYAMA, Ikuro , YAMADA, Shingo
CPC分类号： C07K16/24 , C07K2317/21 , C07K2317/23 , C07K2317/76
摘要： Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.
摘要翻译： 此前，它什么难以获得高亲和力抗体特异性结合做给HMGB-1，但不是HMGB-2。 在这种情况下，本发明人成功地获得的抗体做了比较的反应性通过使用特定的肽作为抗原，以HMGB-1，而不是HMGB-2。 因此实例阐述了本发明人做了抗体具有一个HMGB-1中和活性。 本发明的发明下辖抗体淀粉样变性的动物模型，并作为一个结果，成功实例阐述没有抗体产生显著的治疗效果。
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公开(公告)号：EP3623809A1
公开(公告)日：2020-03-18
申请号：EP18798935.5
申请日：2018-05-11
发明人： HORI, Kanji , HIRAYAMA, Makoto , MARUYAMA, Ikuro , TAGUCHI, Yoshihiro , KUROKAWA, Hiroshi , KOBAYASHI, Kenya , MINAKUCHI, Hiroyoshi
IPC分类号： G01N33/50 , C07K1/22 , C07K14/42 , C07K14/46 , C12M1/00 , C12M1/26 , C12M1/34 , C12Q1/68 , G01N33/574
摘要： To provide a device capable of cancer diagnosis with high sensitivity and specificity, a cancer diagnosis device (1) includes: an extracellular vesicle capturing section (16 to 18) including immobilization supports on which lectins are immobilized respectively, the lectins being each capable of binding specifically to a surface sugar chain included in an extracellular vesicle derived from a cancer cell, the immobilization supports corresponding respectively to one or more kinds of the surface sugar chain; and a detecting section configured to detect a microRNA included in the extracellular vesicle.
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8.发明授权PERIODONTAL-DISEASE-SPECIFIC PEPTIDE, AND TREATMENT AND DIAGNOSIS OF PERIODONTAL DISEASE USING SAME 有权牙周疾病特异性肽，以及使用相同的疾病治疗和诊断牙周病
公开(公告)号：EP2548888B1
公开(公告)日：2017-11-01
申请号：EP11756409.6
申请日：2011-03-17
发明人： MARUYAMA, Ikuro , HASHIGUCHI, Teruto , TANCHAROEN, Salunya , KAWAHARA, Ko-ichi , TANAKA, Kenji , LEE, Lyang-ja
IPC分类号： C07K14/78 , A01K67/027 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/02 , A61P37/06 , C07K7/08 , C07K16/28 , C12Q1/02 , G01N27/62 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/4741 , C07K16/18 , G01N33/564 , G01N2333/4742 , G01N2500/04 , G01N2800/18
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