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公开(公告)号：EP2077271A1
公开(公告)日：2009-07-08
申请号：EP07742762.3
申请日：2007-05-01
IPC分类号： C07H17/08 , A61K31/7048 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C07H17/08 , A61K31/7048 , A61K31/7052 , C07H17/00
摘要： Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a percutaneous coronary transluminal angioplasty, vascular atherosclerosis, hemorrhagic apoplexy, acute myocardial infarction, chronic heart failure, aneurysm, lung cancer metastasis, adult respiratory distress syndrome, asthma, interstitial pulmonary fibrosis, chronic rhinosinusitis, bronchitis or chronic obstructive pulmonary disease (COPD).
摘要翻译： 由式（I）和式（IV）表示的化合物具有MMP-9产生的抑制活性，因此可用作副作用小于传统MMP酶活性抑制剂的药物，作为致癌的预防和治疗药物 血管生成，慢性风湿性关节炎，经皮冠状动脉腔内血管成形术后血管内膜增厚，血管动脉硬化，出血性中风，急性心肌梗塞，慢性心力衰竭，动脉瘤，肺癌转移，成人呼吸窘迫综合征，哮喘，间质性肺纤维化，慢性鼻窦炎， 支气管炎或慢性阻塞性肺病（COPD）。
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公开(公告)号：EP2678349A1
公开(公告)日：2014-01-01
申请号：EP12749570.3
申请日：2012-02-20
发明人： SUGIMOTO, Tomohiro , SASAMOTO, Naoki , KUROSAKA, Jun , HAYASHI, Masato , YAMAMOTO, Kanako , KASHIMURA, Masato , USHIKI, Yasunobu , OGITA, Haruhisa , MIURA, Tomoaki , KANEMOTO, Kenichi , KUMURA, Kou , YOSHIDA, Satoshi , TAMURA, Keiji , SHITARA, Eiki
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/08
摘要： A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).
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公开(公告)号：EP1985620A1
公开(公告)日：2008-10-29
申请号：EP07706316.2
申请日：2007-02-07
发明人： SUGIMOTO, Tomohiro , YAMAMOTO, Kanako , MANAKA, Akira , OGITA, Haruhisa , KUROSAKA, Jun , KAWAMURA, Madoka , KASHIMURA, Masato , SASAMOTO, Naoki , MIURA, Tomoaki , KANEMOTO, Kenichi , OZAWA, Tomohiro , CHIKAUCHI, Ken , SHITARA, Eiki , KUBOTA, Dai
IPC分类号： C07H17/00 , C07H15/12 , A61K31/7052 , A61P31/04
CPC分类号： C07H17/00 , A61K31/7052
摘要： [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria.
[Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.摘要翻译： [目的]提供具有抗血友病流感嗜血杆菌和抗红霉素的细菌（例如耐药性肺炎球菌和链球菌）以及常规红霉素敏感细菌的新型结构的化合物。 [溶液]：由式（I）表示的新型10a-氮杂化合物，其药学上可接受的盐或其溶剂合物或其制备的中间体。 本发明的化合物对流感嗜血杆菌，抗红霉素的肺炎球菌等具有优异的抗菌活性，因此可用作感染性疾病的治疗剂。
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公开(公告)号：EP2678349B1
公开(公告)日：2016-01-13
申请号：EP12749570.3
申请日：2012-02-20
发明人： SUGIMOTO, Tomohiro , SASAMOTO, Naoki , KUROSAKA, Jun , HAYASHI, Masato , YAMAMOTO, Kanako , KASHIMURA, Masato , USHIKI, Yasunobu , OGITA, Haruhisa , MIURA, Tomoaki , KANEMOTO, Kenichi , KUMURA, Kou , YOSHIDA, Satoshi , TAMURA, Keiji , SHITARA, Eiki
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/08
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