公开(公告)号：EP1466969A1

公开(公告)日：2004-10-13

申请号：EP03701755.5

申请日：2003-01-17

申请人： TAKARA BIO INC.

发明人： SAKAI, Takeshi ,  AMARUME, Hitomi ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C12N9/42 ,  C07H11/00 ,  C08B37/00 ,  C12P19/04

CPC分类号： C12N9/2408 ,  C07H11/00 ,  C08B37/0006 ,  C12N9/18 ,  C12N9/2402 ,  C12P19/04 ,  C12P19/14 ,  C12P19/20 ,  C12Y302/01051

摘要： An enzyme capable of degrading sulfated fucan originating in a brown alga of Fucales which is useful in sugar chain engineering; a process for producing this enzyme; an oligosaccharide obtained by treating sulfated fucan with the enzyme; and production thereof.

摘要翻译： 能够降解起源于Fucales棕色藻类的硫酸化岩藻糖的酶，其可用于糖链工程; 一种生产该酶的方法; 通过用酶处理硫酸化的岩藻糖获得的寡糖; 及其生产。

公开(公告)号：EP1106624B1

公开(公告)日：2003-04-09

申请号：EP99937011.7

申请日：1999-08-10

申请人： TAKARA BIO INC.

发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： C07K5/027 ,  C07K1/02 ,  C07C323/60 ,  C07C319/18 ,  A61K31/195 ,  C07K5/02 ,  A61K38/06

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR1, Y is =O and Z is H, and when it is a cyclopentane ring, X is =O, Y is OR2 and Z is OR3, (wherein R1 is R4 or -(CO)-R5; R2 is H,-R6 or -(CO)-R7; and R3 is H, R8 or (CO)-R9 (wherein R4, R5, R6, R7, R8 and R9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R5, R7 and R9 may be each H), provided that the case where R2=R3=H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.

摘要翻译： 由通式（I）表示的5元环化合物，其光学活性异构体或其盐。 这些化合物具有包括制癌作用在内的生理活性。 在所述式中，五元环中由虚线表示的键表示该5元环可以是具有双键的环戊烯环或饱和的环戊烷环，并且当5元环是环戊烯环时 X是OR1，Y是= O且Z是H，并且当它是环戊烷环时，X是= O，Y是OR2并且Z是OR3，（其中R1是R4或 - （CO）-R5; R2是 （CO）-R7;和R3是H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同并且各自代表脂族，芳族或 脂族芳族基团，并且R5，R7和R9可以各自为H），条件是排除R2 = R3 = H的情况）。 W表示从含SH化合物中除去SH得到的残基。

公开(公告)号：EP1038879B1

公开(公告)日：2009-04-01

申请号：EP98953005.0

申请日：1998-11-11

申请人： TAKARA BIO INC.

发明人： ENOKI, Tatsuji A-204, T.O Kopo Ishiyama ,  SAGAWA, Hiroaki 503, Hamoparesu Kusatsu ,  TOMINAGA, Takanari ,  NISHIYAMA, Eiji ,  KOYAMA, Nobuto ,  SAKAI, Takeshi 230, Raionzumanshon Shinagawamachi ,  YU, Fu-Gong ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C07H3/10 ,  A23L3/3544

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1), foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

公开(公告)号：EP1112742B1

公开(公告)日：2004-11-03

申请号：EP99937010.9

申请日：1999-08-10

申请人： TAKARA BIO INC.

发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu, A-406, Takarashuzoshataku ,  SAGAWA, Hiroaki, 503, Hamoparesu-Kusatsu ,  TOMINAGA, Takanari ,  NISHIYAMA, Eiji ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： A61K31/215 ,  A61K31/22 ,  A61P37/02 ,  A61P35/00

CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula ÄIÜ, optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

公开(公告)号：EP1176153B1

公开(公告)日：2004-09-22

申请号：EP00904062.7

申请日：2000-02-21

申请人： TAKARA BIO INC.

发明人： SAKAI, Takeshi, 203, Raionzumanshon-Shinakawamachi ,  KIMURA, Hitomi ,  KOJIMA, Kaoru ,  KATAYAMA, Kaoru, Central Research Laboratories ,  SHIMANAKA, Kazuo ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C08B37/00 ,  C12N9/38 ,  C07H5/10

CPC分类号： C08B37/006 ,  C12N9/2402 ,  C12P19/04

公开(公告)号：EP1086952B1

公开(公告)日：2007-08-15

申请号：EP99923961.9

申请日：1999-06-08

申请人： TAKARA BIO INC.

发明人： ENOKI, Tatsuji ,  TOMONO, Jun ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： C07D493/08

CPC分类号： A61K31/7004 ,  A23L3/3535 ,  A23L3/3562 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/351 ,  A61K31/357 ,  A23V2250/60 ,  A23V2250/608 ,  A23V2250/5024 ,  A23V2250/5036

摘要： Therapeutic or preventive agents for diseases requiring apoptosis induction, cancerous diseases, diseases requiring the inhibition of active oxygen production, those requiring the inhibition of nitrogen monoxide production, those requiring the inhibition of prostaglandin synthesis, those requiring the inhibition of synovial cell proliferation, those requiring the induction of heat shock protein production or those requiring the inhibition of α-glycosidase, which contain as the active ingredient compounds selected from among compounds represented by general formula (I), (wherein X and Y are each H or CH2OH, provided that when X is CH2OH, Y is H, while when X is H, Y is CH2OH), those represented by general formula (II), (wherein R is a residue obtained by freeing a compound having an SH group from the SH group) and salts of both; and foods, drinks, cosmetics and so on, containing compounds selected from among compounds of general formula (I), those of general formula (II) and salts of both.

公开(公告)号：EP1380641A1

公开(公告)日：2004-01-14

申请号：EP02720484.1

申请日：2002-04-18

申请人： TAKARA BIO INC.

发明人： SAKAI, Takeshi ,  KIMURA, Hitomi ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C12N9/88 ,  C07H11/00 ,  C12N1/20 ,  C12P19/04

CPC分类号： C12P19/44 ,  C07H7/033 ,  C07H11/00 ,  C08B37/006 ,  C12N9/88 ,  C12P19/04

摘要： An enzyme which decomposes a sulfated fucoglucuronomannan and is useful in the field of glycotechnology; a process for producing the enzyme; a fucoidan fraction reduced in the number of the kinds of molecules and useful as a reagent in glycotechnology; a sulfated fucoglucuronomannan oligosaccharide; and processes for producing the fraction and oligosaccharide.

摘要翻译： 一种分解硫酸化葡萄糖葡萄糖甘露聚糖的酶，可用于糖业技术领域; 一种生产酶的方法; 岩藻依聚糖级分减少了分子数目，可用作糖酵母中的试剂; 硫酸化的葡萄糖葡萄糖苷寡糖; 以及生产级分和寡糖的方法。

公开(公告)号：EP1277834A1

公开(公告)日：2003-01-22

申请号：EP01921895.7

申请日：2001-04-19

申请人： TAKARA BIO INC.

发明人： SAKAI, Takeshi ,  ISHIZUKA, Kumiko ,  KOJIMA, Kaoru ,  SHIMANAKA, Kazuo ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C12N9/24 ,  C12P19/04 ,  C08B37/00 ,  C12N1/20

CPC分类号： C12Y302/01139 ,  C08B37/00 ,  C08B37/006 ,  C12N9/2402 ,  C12P19/14 ,  C12R1/01 ,  C12Y302/01044

摘要： Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

摘要翻译： 三种降解硫酸葡糖醛酸葡聚糖的酶; 生产这些酶的方法; 这些酶的活化剂; 葡糖醛酸葡聚糖硫酸酯及其降解产物; 和一种新型微生物。