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公开(公告)号：EP0541578B1
公开(公告)日：1998-10-14
申请号：EP91912593.0
申请日：1991-07-05
发明人： PASHLEY, Richard, Mark , SENDEN, Timothy, John , MORRIS, Richard Alan , GUTHRIE, James, Thomas , HE, Wei, Dong , NINHAM, Barry William
IPC分类号： C08F26/06 , C08F126/06 , C07D487/22 , C09D139/04 , C08G61/12
CPC分类号： C07D487/22 , B01D69/122 , B01D71/44 , C02F1/64 , C08F26/06 , C08G61/124 , G01N27/3335
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公开(公告)号：EP1027080B1
公开(公告)日：2010-11-17
申请号：EP98934690.3
申请日：1998-07-23
发明人： NAIR, Chenicheri, Hariharan , SHATS, Elena, Alexandra , BURCH, William, Martin , BROWITT, Rodney, James , SENDEN, Timothy, John
CPC分类号： A61K51/1251
摘要： A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable reagent comprising a plurality of discrete particles, each of the particles comprising a plurality of layers of carbon and being capable of binding to fibrin; and detecting the presence of the particles in the source. The particles may also comprise a detectable marker encased in said plurality of layers of carbon, the presence of said marker being capable of detection in said source.
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公开(公告)号：EP0541578A1
公开(公告)日：1993-05-19
申请号：EP91912593.0
申请日：1991-07-05
发明人： PASHLEY, Richard, Mark , SENDEN, Timothy, John , MORRIS, Richard Alan , GUTHRIE, James, Thomas , HE, Wei, Dong
IPC分类号： B01D69 , B01D71 , C02F1 , C07D487 , C08F26 , C08F234 , C08G61 , C08G63 , C08L39 , C09D137 , C09D139 , G01N27
CPC分类号： C07D487/22 , B01D69/122 , B01D71/44 , C02F1/64 , C08F26/06 , C08G61/124 , G01N27/3335
摘要： Matériaux polymérisables produits par réaction d'un pyrrole et d'un aldéhyde insaturé ou polymérisable, de préférence un aldéhyde bêta-insaturé. Polymères obtenus à partir du matériau polymérisable décrit ci-dessus et copolymères obtenus à partir dudit matériau et au moins d'un autre monomère polymérisable de type connu. On peut utiliser ces polymères et copolymères pour fabriquer des pellicules, des revêtements ou d'autres structures.
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公开(公告)号：EP2646037A1
公开(公告)日：2013-10-09
申请号：EP11845528.6
申请日：2011-11-29
发明人： STEPHENS, Ross, Wentworth , PARISH, Christopher, Richard , FREEMAN, Craig, Geoffrey , SENDEN, Timothy, John
IPC分类号： A61K31/70 , A61K31/715 , A61K31/737 , A61K31/7016 , A61K31/724 , A61P7/00 , A61K31/702 , A61K31/727
CPC分类号： A61K31/737 , A61K31/70 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/724 , A61K31/727
摘要： The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.
摘要翻译： 本发明涉及抑制受试者中细胞外组蛋白的细胞毒性活性的方法，所述方法包括向受试者施用有效量的聚阴离子。 具体地说，本发明涉及一种治疗罹患败血症且使用聚阴离子与之迅速形成复合物并因此中和或抑制细胞外组蛋白蛋白质的细胞毒性活性的病人的方法，所述胞外组蛋白质例如在脓毒症的血液循环中发现的细胞毒素活性 耐心。
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5.发明授权A METHOD OF FORMING AN INJECTABLE RADIOACTIVE COMPOSITION OF A CARBON ENCAPSULATED RADIOACTIVE PARTICULATE 有权用于形成可注射的放射性成分由碳放射性方法。包含粒子状物质
公开(公告)号：EP1877105B1
公开(公告)日：2013-08-14
申请号：EP06721434.6
申请日：2006-04-28
发明人： BROWITT, Rodney, James , BURCH, William, Martin , SENDEN, Timothy, John , STEPHENS, Ross, Wentworth
IPC分类号： A61K51/12 , A61K51/02 , A61K103/10
CPC分类号： A61K51/1244
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公开(公告)号：EP2282782A1
公开(公告)日：2011-02-16
申请号：EP09733887.5
申请日：2009-04-23
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/081 , A61K51/10
摘要： The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.
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公开(公告)号：EP2282782B1
公开(公告)日：2018-01-24
申请号：EP09733887.5
申请日：2009-04-23
IPC分类号： A61K51/06 , A61K49/12 , A61K49/14 , A61K49/16 , A61K51/08 , A61K51/10 , A61P35/00 , A61K51/12
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/081 , A61K51/10
摘要： The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.
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公开(公告)号：EP2282781A1
公开(公告)日：2011-02-16
申请号：EP09734815.5
申请日：2009-04-23
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/1272 , A61K51/1282
摘要： The present invention relates to a method for preparing a radiolabeled synthetic polymer, the method comprising contacting a synthetic polymer with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising an electrolyte concentration or pH selected to promote short-range attractive forces between the nanoparticles and the synthetic polymer by attenuating long-range electrostatic repulsive forces.
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9.发明公开RADIO-LABELLED FERRITE PARTICLES AND METHODS FOR THE MANUFACTURE AND USE THEREOF 审中-公开放射性标志着铁素体及其制造方法与用途
公开(公告)号：EP1337277A1
公开(公告)日：2003-08-27
申请号：EP01980054.9
申请日：2001-10-24
CPC分类号： A61K51/02 , A61K51/1244
摘要： A method for the production of radio-labelled ferrite nanoparticles comprising the steps of: (a) adding an aqueous solution containing Fe?2+ and Fe3+¿ ions and a radioisotope to an alkaline solution and agitating the mixture to form a precipitate comprising ferrite particles labelled with the radioisotope; and (b) isolating and washing the precipitated labelled particles.
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10.发明授权
公开(公告)号：EP2646037B1
公开(公告)日：2019-01-09
申请号：EP11845528.6
申请日：2011-11-29
发明人： STEPHENS, Ross, Wentworth , PARISH, Christopher, Richard , FREEMAN, Craig, Geoffrey , SENDEN, Timothy, John
IPC分类号： A61K31/70 , A61K31/715 , A61K31/737 , A61K31/7016 , A61K31/724 , A61P7/00 , A61K31/702 , A61K31/727
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