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公开(公告)号：EP2282782B1
公开(公告)日：2018-01-24
申请号：EP09733887.5
申请日：2009-04-23
IPC分类号： A61K51/06 , A61K49/12 , A61K49/14 , A61K49/16 , A61K51/08 , A61K51/10 , A61P35/00 , A61K51/12
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/081 , A61K51/10
摘要： The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.
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公开(公告)号：EP2282781A1
公开(公告)日：2011-02-16
申请号：EP09734815.5
申请日：2009-04-23
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/1272 , A61K51/1282
摘要： The present invention relates to a method for preparing a radiolabeled synthetic polymer, the method comprising contacting a synthetic polymer with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising an electrolyte concentration or pH selected to promote short-range attractive forces between the nanoparticles and the synthetic polymer by attenuating long-range electrostatic repulsive forces.
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3.发明授权
公开(公告)号：EP2646037B1
公开(公告)日：2019-01-09
申请号：EP11845528.6
申请日：2011-11-29
发明人： STEPHENS, Ross, Wentworth , PARISH, Christopher, Richard , FREEMAN, Craig, Geoffrey , SENDEN, Timothy, John
IPC分类号： A61K31/70 , A61K31/715 , A61K31/737 , A61K31/7016 , A61K31/724 , A61P7/00 , A61K31/702 , A61K31/727
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公开(公告)号：EP2282781B1
公开(公告)日：2018-09-05
申请号：EP09734815.5
申请日：2009-04-23
CPC分类号： A61K51/1251 , A61K41/0095 , A61K51/06 , A61K51/08 , A61K51/1272 , A61K51/1282
摘要： The present invention relates to a method for preparing a radiolabeled synthetic polymer, the method comprising contacting a synthetic polymer with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising an electrolyte concentration or pH selected to promote short-range attractive forces between the nanoparticles and the synthetic polymer by attenuating long-range electrostatic repulsive forces.
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5.发明公开A METHOD OF FORMING AN INJECTABLE RADIOACTIVE COMPOSITION OF A CARBON ENCAPSULATED RADIOACTIVE PARTICULATE 有权用于形成可注射的放射性成分由碳放射性方法。包含粒子状物质
公开(公告)号：EP1877105A1
公开(公告)日：2008-01-16
申请号：EP06721434.6
申请日：2006-04-28
发明人： BROWITT, Rodney, James , BURCH, William, Martin , SENDEN, Timothy, John , STEPHENS, Ross, Wentworth
IPC分类号： A61K51/12 , A61K51/02 , A61K103/10
CPC分类号： A61K51/1244
摘要： A method of forming an injectable radioactive composition, the method comprising the steps of: (a) depositing a solid form of technetium onto a carbon crucible; (b) preheating the solid form of technetium to remove any carrier; (c) plasma ablating the technetium and portions of the carbon crucible; (d) allowing the carbon and technetium metal to co-condense from the gas phase to produce a nanoparticle composite aerosol in an inert gas; (e) dispersing the nanoparticle composite in water containing a low concentration of surfactant using an electrostatic precipitator; (f) size fractionating the nanoparticle dispersion by filtration with hydrophilic membranes of known pore size.
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公开(公告)号：EP3016688B1
公开(公告)日：2018-04-25
申请号：EP13888774.0
申请日：2013-12-20
IPC分类号： A61K51/12 , A61K51/06 , A61K103/00 , A61P35/00
CPC分类号： A61K51/065 , A61K51/00 , A61K51/02 , A61K51/06 , A61K51/1244 , A61K51/1251
摘要： The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.
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公开(公告)号：EP3016688A1
公开(公告)日：2016-05-11
申请号：EP13888774.0
申请日：2013-12-20
IPC分类号： A61K51/06 , A61K103/00 , A61P35/00
CPC分类号： A61K51/065 , A61K51/1244 , A61K51/1251
摘要： The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.
摘要翻译： 本发明涉及包含聚合物，放射性同位素和固定剂的放射性标记材料，其中固定剂能够将放射性同位素固定在聚合物上或聚合物中，并且其中固定剂是包含给电子基团的大分子。 本发明还涉及制备放射性标记材料的方法，使用放射性标记材料制备用于治疗癌症和/或放射线成像的药物，以及使用放射性标记材料治疗癌症。 进一步描述了使用固定剂来将放射性同位素固定在聚合物上或聚合物中。
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公开(公告)号：EP0192671A1
公开(公告)日：1986-09-03
申请号：EP85904069.0
申请日：1985-08-13
发明人： STEPHENS, Ross, Wentworth , GOLDER, Jeffrey, Philip , GOSS, Neil, Howard , ANTALIS, Toni, Marie
IPC分类号： G01N33 , A61K35 , A61K38 , A61K39 , A61P35 , C07K1 , C07K14 , C07K16 , C07K19 , C12N5 , C12P21 , C12Q1 , C12R1
CPC分类号： C07K14/8132 , A61K38/00 , G01N33/574 , G01N2333/811 , G01N2333/8132
摘要： Il a été démontré que le minactivin, inactivant protéique de l'activant de plasminagène du type urokinase, est un inactivant naturel de cet activant de plasminogène qui est associé avec les tumeurs invasives, et qu'il représente pour conséquent un élément crucial dans le système normal de défense de l'organisme contre les invasions et les métastases tumorales. Ce composé peut être produit par la culture in vitro de cellules produissant du minactivin, et par l'extraction du surnageant de la culture cellulaire. En régulant les conditions de culture, il est possible de produire le minactivin protéique sous une forme partiellement purifiée qui peut être utilisée pour le diagnostic et le traitement de tumeurs.
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公开(公告)号：EP2646037A1
公开(公告)日：2013-10-09
申请号：EP11845528.6
申请日：2011-11-29
发明人： STEPHENS, Ross, Wentworth , PARISH, Christopher, Richard , FREEMAN, Craig, Geoffrey , SENDEN, Timothy, John
IPC分类号： A61K31/70 , A61K31/715 , A61K31/737 , A61K31/7016 , A61K31/724 , A61P7/00 , A61K31/702 , A61K31/727
CPC分类号： A61K31/737 , A61K31/70 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/724 , A61K31/727
摘要： The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.
摘要翻译： 本发明涉及抑制受试者中细胞外组蛋白的细胞毒性活性的方法，所述方法包括向受试者施用有效量的聚阴离子。 具体地说，本发明涉及一种治疗罹患败血症且使用聚阴离子与之迅速形成复合物并因此中和或抑制细胞外组蛋白蛋白质的细胞毒性活性的病人的方法，所述胞外组蛋白质例如在脓毒症的血液循环中发现的细胞毒素活性 耐心。
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10.发明授权A METHOD OF FORMING AN INJECTABLE RADIOACTIVE COMPOSITION OF A CARBON ENCAPSULATED RADIOACTIVE PARTICULATE 有权用于形成可注射的放射性成分由碳放射性方法。包含粒子状物质
公开(公告)号：EP1877105B1
公开(公告)日：2013-08-14
申请号：EP06721434.6
申请日：2006-04-28
发明人： BROWITT, Rodney, James , BURCH, William, Martin , SENDEN, Timothy, John , STEPHENS, Ross, Wentworth
IPC分类号： A61K51/12 , A61K51/02 , A61K103/10
CPC分类号： A61K51/1244
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