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1.发明公开METHOD FOR REGULATING METABOLISM WITH DOPAMINE BETA HYDROXYLASE INHIBITORS 失效方法调节代谢与多巴胺BETA HYDROXYLASEINHIBITOREN的
公开(公告)号：EP0836445A1
公开(公告)日：1998-04-22
申请号：EP96922476.0
申请日：1996-06-05
申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , ERGO SCIENCE INCORPORATED
CPC分类号： A61K31/135 , A61K31/00 , A61K31/015 , A61K31/03 , A61K31/05 , A61K31/137 , A61K31/145 , A61K31/27 , A61K31/275 , A61K31/277 , A61K31/325 , A61K31/381 , A61K31/44 , Y10S514/824 , Y10S514/866
摘要： Disclosed herein are methods for regulating or ameliorating lipid and glucose metabolism and reducing in a vertebrate animal body fat stores, insulin resistance, hyperinsulinemia, hyperglycemia, hyperlipidemia, elevated blood lipoproteins (such as triglycerides and cholesterol including chylomicrons, VLDL and LDL) and/or increasing in the subject the plasma HDL. The methods comprise administration or timed administration of inhibitors or dopamine beta hydroxylase (DBH).
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公开(公告)号：EP0833636A1
公开(公告)日：1998-04-08
申请号：EP96922478.0
申请日：1996-06-05
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , A61K38/2257 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
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公开(公告)号：EP0833625A1
公开(公告)日：1998-04-08
申请号：EP96919438.0
申请日：1996-06-05
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/13 , A61K31/16 , Y10S514/866
摘要： This invention relates to a method for modifying metabolism in a vertebrate animal which entails the administration of pantethine or cysteamine at a predetermined time daily. The method is useful in the treatment of hyperglycemia, glucose intolerance, insulin resistance, and hyperinsulinemia.
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4.发明公开IMPROVED METHODS FOR THE DETERMINATION AND ADJUSTMENT OF PROLACTIN DAILY RHYTHMS 失效法确定和设置THE DAY催乳素节律紊乱
公开(公告)号：EP0769148A1
公开(公告)日：1997-04-23
申请号：EP95926737.0
申请日：1995-06-23
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/4985 , A61K31/00 , A61K31/475 , A61K45/06 , G01N33/74
摘要： Disclosed are methods for detecting and adjusting abnormalities in prolactin daily rhythms. Provided is a method comparing a prolactin profile of a vertebrate subject to the prolactin profile of other vertebrate subjects having a normal prolactin profile; and adjusting the prolactin profile of the subject to cause the profile of the subject to conform to (or approach) the normal prolactin profile. Also provided is a method for evaluating the daily prolactin profile of a human subject wherein the method provides for comparing a set of at least two prolactin levels of the human and comparing them to corresponding prolactin levels for healthy humans (or a preestablished average prolactin curve for healthy humans) at the same time points. The method also provides for determining whether a human subject has an abnormal prolactin profile.
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5.发明公开METHOD FOR TREATMENT OF OBESITY USING PROLACTIN MODULATORS AND DIET 失效PROLACTINMODULATOREN和饮食用于生产药物中的肥胖治疗
公开(公告)号：EP0808164A1
公开(公告)日：1997-11-26
申请号：EP95907471.0
申请日：1995-01-06
申请人： ERGO SCIENCE INCORPORATED , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/4985 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/2257 , A61K45/06 , G01N33/74 , Y10S514/866 , Y10S514/884 , Y10S514/909 , A61K2300/00
摘要： The present invention is directed to an improvement in a method of weight and/or body-fat reduction comprising a (preferably moderate) reduction in the caloric intake of a subject in need of such treatment in combination with administration to said subject of a prolactin inhibitor. Additionally, the present invention is directed to an improvement in a method for altering and/or resetting prolactin profiles (and thereby controlling one or more metabolic disorders such as obesity, excessive body fat, hyperlipidemia, hyperlipoproteinemia, hyperglycemia, hypercholesterolemia, hyperinsulinemia, insulin resistance, glucose intolerance, and Type II diabetes) comprising administration to a subject in need of such treatment of a prolactin inhibitor at a predetermined time or times during a 24-hour period in combination with a (preferably moderate) reduction of the caloric intake of said subject.
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公开(公告)号：EP0833636B1
公开(公告)日：2006-08-23
申请号：EP96922478.1
申请日：1996-06-05
申请人： PLIVA D.D. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , A61K38/2257 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
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7.发明授权USE OF PROLACTIN MODULATORS AND DIET FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF OBESITY 失效PROLACTINMODULATOREN和饮食用于生产药物中的肥胖治疗
公开(公告)号：EP0808164B1
公开(公告)日：2005-03-16
申请号：EP95907471.7
申请日：1995-01-06
申请人： PLIVA d.d. , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
CPC分类号： A61K31/4985 , A61K31/00 , A61K31/13 , A61K31/137 , A61K31/15 , A61K31/166 , A61K31/195 , A61K31/221 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/405 , A61K31/435 , A61K31/439 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/475 , A61K31/48 , A61K31/54 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K38/2257 , A61K45/06 , G01N33/74 , Y10S514/866 , Y10S514/884 , Y10S514/909 , A61K2300/00
摘要： The present invention is directed to an improvement in a method of weight and/or body-fat reduction comprising a (preferably moderate) reduction in the caloric intake of a subject in need of such treatment in combination with administration to said subject of a prolactin inhibitor. Additionally, the present invention is directed to an improvement in a method for altering and/or resetting prolactin profiles (and thereby controlling one or more metabolic disorders such as obesity, excessive body fat, hyperlipidemia, hyperlipoproteinemia, hyperglycemia, hypercholesterolemia, hyperinsulinemia, insulin resistance, glucose intolerance, and Type II diabetes) comprising administration to a subject in need of such treatment of a prolactin inhibitor at a predetermined time or times during a 24-hour period in combination with a (preferably moderate) reduction of the caloric intake of said subject.
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公开(公告)号：EP0831819B1
公开(公告)日：2002-09-18
申请号：EP96921632.4
申请日：1996-06-05
申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , The General Hospital doing business as Massachusetts General Hospital
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , Y10S514/908 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
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公开(公告)号：EP0772396B1
公开(公告)日：2003-09-10
申请号：EP95927448.1
申请日：1995-07-07
申请人： The General Hospital Corporation doing business as Massachusetts General Hospital , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K31/40 , A61K31/165 , A61K31/445 , A61K31/54 , A61K31/13 , A61K31/47 , A61K31/48 , A61K38/22 , A61P37/02
CPC分类号： A61K38/225 , A61K31/00 , A61K31/137 , A61K31/166 , A61K31/40 , A61K31/405 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/5415 , A61K38/2257 , A61K45/06 , A61K2300/00
摘要： Methods for rectifying or ameliorating abnormal responses of mammalian immune systems is provided. Also provided are methods for modifying normal responses of the mammalian immune system. Further provided is a method for treating a mammal having an immune dysfunction by administering to the mammal a prolactin reducer and/or enhancer at a predetermined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young mammal of the same species, thereby ameliorating said immune dysfunction. Also provided is a method of upregulating or augmenting an immune response in a mammal.
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公开(公告)号：EP0831819A1
公开(公告)日：1998-04-01
申请号：EP96921632.0
申请日：1996-06-05
申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , The General Hospital doing business as Masschusetts General Hospital
CPC分类号： A61K31/166 , A61K31/4045 , A61K31/405 , A61K31/454 , A61K31/48 , Y10S514/908 , A61K31/40 , A61K2300/00
摘要： This invention relates to a method for inhibiting the growth of neoplasms, in a mammal having a prolactin profile. This method involves comparing the prolactin profile of the afflicted mammal to a standard prolactin profile for healthy mammals of the same species and sex and adjusting the prolactin profile of the afflicted mammal to conform to or approach the standard prolactin profile for a mammal of the same species and sex of the afflicted mammal, thereby inhibiting the neoplastic growth.
摘要翻译： 本发明涉及在具有催乳素特征的哺乳动物中抑制肿瘤生长的方法。 该方法涉及将患病哺乳动物的催乳素特征与相同物种和性别的健康哺乳动物的标准催乳素特征进行比较，并调整患病哺乳动物的催乳素特征以符合或接近相同物种哺乳动物的标准催乳素特征 和患病的哺乳动物的性别，从而抑制肿瘤生长。
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