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公开(公告)号：EP2066339B1
公开(公告)日：2014-08-13
申请号：EP07842706.9
申请日：2007-09-18
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , A61K49/00 , C12P1/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
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公开(公告)号：EP2579901A2
公开(公告)日：2013-04-17
申请号：EP11793174.1
申请日：2011-06-09
IPC分类号： A61K48/00
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译： 本文提供了用于增强对弯曲杆菌感染的抗性或用于增强对弯曲杆菌的免疫应答的疫苗载体和方法。 疫苗载体包括编码选自SEQ ID NO：7-9的抗原性多肽或其片段的第一多核苷酸。 载体还可以包含免疫刺激性多肽。 该方法包括将疫苗载体施用于受试者。
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公开(公告)号：EP2525817B8
公开(公告)日：2017-09-20
申请号：EP11735230.2
申请日：2011-01-21
发明人： BERGHMAN, Luc , BOTTJE, Walter , HARGIS, Billy , LAYTON, Sherryll
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，其包含药学上可接受的载体，合适地为用于口服或鼻腔给药的载体。 还提供了通过将本文公开的疫苗载体或组合物给予受试者来增强免疫应答，特别是抗体免疫应答和合适的IgA应答的方法。
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公开(公告)号：EP2525817A1
公开(公告)日：2012-11-28
申请号：EP11735230.2
申请日：2011-01-21
发明人： BERGHMAN, Luc , BOTTJE, Walter , HARGIS, Billy , LAYTON, Sherryll
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
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公开(公告)号：EP3578190A1
公开(公告)日：2019-12-11
申请号：EP19173788.1
申请日：2014-03-14
发明人： BIELKE, Lisa , LAYTON, Sherryll , HARGIS, Billy , PUMFORD, Neil R. , FAULKNER, Olivia B. , BERGHMAN, Luc , ABI-GHANEM, Daad
摘要： Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
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公开(公告)号：EP2579901B1
公开(公告)日：2019-08-07
申请号：EP11793174.1
申请日：2011-06-09
IPC分类号： A61K39/02 , C07K14/205
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7.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS 审中-公开增强对肠道病原体免疫应答的组合物和方法
公开(公告)号：EP2968423A1
公开(公告)日：2016-01-20
申请号：EP14769698.3
申请日：2014-03-14
发明人： BIELKE, Lisa , LAYTON, Sherryll , HARGIS, Billy , PUMFORD, Neil R. , FAULKNER, Olivia B. , BERGHMAN, Luc , ABI-GHANEM, Daad
IPC分类号： A61K35/74
CPC分类号： A61K39/0275 , A61K39/0258 , A61K39/105 , A61K39/107 , A61K2039/523 , A61K2039/53 , C07K16/1232 , C07K2317/34 , C12N15/85 , Y02A50/472 , Y02A50/474 , Y02A50/482
摘要： Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
摘要翻译： 提供了能够引发对肠细菌的免疫应答的疫苗载体和使用它的方法。 疫苗载体包括编码PAL多肽的多核苷酸。 PAL多肽可以在疫苗载体的表面上表达。 疫苗载体还可以包含编码免疫刺激性多肽例如CD154多肽或HMGB1多肽的第二多肽。
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公开(公告)号：EP3097926B1
公开(公告)日：2019-10-02
申请号：EP16175274.6
申请日：2008-11-03
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System , University of Guelph
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Saeed , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
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公开(公告)号：EP2525817B1
公开(公告)日：2017-08-09
申请号：EP11735230.2
申请日：2011-01-21
发明人： BERGHMAN, Luc , BOTTJE, Walter , HARGIS, Billy , LAYTON, Sherryll
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
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10.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZURVERSTÄRKUNGVON IMMUNREAKTIONENGEGENÜBEREIMERIA
公开(公告)号：EP3097926A1
公开(公告)日：2016-11-30
申请号：EP16175274.6
申请日：2008-11-03
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System , University of Guelph
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Saeed , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供包含TRAP多肽和包含TRAP多肽的肠炎沙门氏杆菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
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