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15 条记录 (耗时 0.016 秒)

    Extraction and purification of an anticoagulant substance from the south american leech, haementeria ghilianii
    4.
    发明公开
    Extraction and purification of an anticoagulant substance from the south american leech, haementeria ghilianii 失效
    Extraktion和Reinigung einer Antigerinnungssubstanz aus densüdamerikanischenBlutegeln Haementeria ghilianii。

    公开(公告)号：EP0346894A2

    公开(公告)日：1989-12-20

    申请号：EP89110877.1

    申请日：1989-06-15

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Cardin, Alan D.

    IPC分类号： C07K1/16 ,  C07K14/815 ,  A61K38/58

    CPC分类号： C07K14/815 ,  A61K38/00 ,  Y10S435/815 ,  Y10S514/822 ,  Y10S530/855

    摘要： Applicant has isolated a Factor X a inhibiting substance from the salivary gland extract of the leech H. ghilianii . The extract is subjected to separation using both DEAE-cellulose and heparin-agarose chromatography resins eluting with an increasing salt gradient. The extract is subjected to affinity chromatography using Factor X a bound to an Affi-Gel-15 resin eluting with HEPES containing benzamidine. Reverse phase chromatography yields several purified peptides or proteins having Factor X a inhibiting activity. The properties and clinical compositions of these FX a inhibitors are described.

    摘要翻译： 申请人从水蛭H.hilianii的唾液腺提取物中分离出一种因子Xa抑制物质。 使用DEAE-纤维素和肝素 - 琼脂糖层析树脂进行分离，用逐渐增加的盐梯度洗脱。 使用与使用含有苯甲脒的HEPES洗脱的Affi-Gel-15树脂的因子Xa进行亲和层析。 反相色谱法产生几种纯化的肽或具有因子Xa抑制活性的蛋白质。 描述了这些FXa抑制剂的性质和临床组成。

    Phosphorylated flavanoids in the treatment of viral diseases
    5.
    发明公开
    Phosphorylated flavanoids in the treatment of viral diseases 失效
    磷酰胆碱（Flavonoide zur Behandlung von Viruserkrankungen）。

    公开(公告)号：EP0543555A1

    公开(公告)日：1993-05-26

    申请号：EP92310277.6

    申请日：1992-11-11

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Cardin, Alan D. ,  Tyms, A. Stanley

    IPC分类号： A61K31/665

    CPC分类号： A61K31/665

    摘要： Certain phosphorylated flavanoids are disclosed to be effective in treating retroviral infections including HIV infections as well as infections of herpes simplex virus and cytomegalovirus.

    摘要翻译： 公开了某些磷酸化类黄酮在治疗包括HIV感染以及单纯疱疹病毒和巨细胞病毒感染的逆转录病毒感染方面是有效的。

    Immunosuppressant peptides
    7.
    发明公开
    Immunosuppressant peptides 失效
    免疫抑制肽。

    公开(公告)号：EP0297456A2

    公开(公告)日：1989-01-04

    申请号：EP88110111.7

    申请日：1988-06-24

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Cardin, Alan D. ,  Bowlin, Terry L. ,  Krstenansky, John L.

    IPC分类号： C07K7/08 ,  C07K7/06 ,  A61K37/02 ,  C07K1/04

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/10022

    摘要： Novel peptides having a fragment containing 2 or 3 Arg or Lys residues and having a fragment containing 2 or 3 Gly, Leu, Ile, or Thr residues adjacent to the carboxy end of the first fragment and having amino and carboxy tails consisting of chains made up of any amino acids are immunosuppressant agents and can suppress the lymphocyte system by suppressing lymphocyte proliferation.
    The formula is as follows:
          Tn-A-B-C-D-Tc
    wherein
          Tn is an amino terminal residue selected from hydrogen, one or two alkyl groups of from 1 to 6 carbon atoms, one or two acyl groups of from 2 to 10 carbon atoms, carbobenzyloxy, and t -butyloxy­carbonyl;
          A is a peptide fragment containing from 3 to 12 residues of any amino acid;
          B is a peptide fragment containing 2 or 3 amino acid residues selected from Arg and Lys;
          C is a peptide fragment containing 2 or 3 amino acid residues selected from Gly, Leu, Ile, and Thr;
          D is a peptide fragment containing from 1 to 12 residues of any amino acid; and
          Tc is a carboxy terminal residue selected from OH, (C₁-C₆)alkoxy, amino, mono- or di-(C₁-C₄)alkyl substituted amino, and benzylamino.

    摘要翻译： 具有包含2或3个Arg或Lys残基的片段的新型肽，并且具有与第一片段的羧基末端相邻的2或3个Gly，Leu，Ile或Thr残基的片段，并具有由构成的链组成的氨基和羧基尾 任何氨基酸都是免疫抑制剂，可通过抑制淋巴细胞增殖来抑制淋巴细胞系统。 该公式如下：Tn-ABCD-Tc其中Tn是选自氢，一个或两个1-6个碳原子的一个或两个烷基，一个或两个2-10个碳原子的酰基的氨基末端残基，苄氧羰基， 和叔丁氧基羰基; A是含有任何氨基酸的3-12个残基的肽片段; B是含有选自Arg和Lys的2或3个氨基酸残基的肽片段; C是含有选自Gly，Leu，Ile和Thr的2或3个氨基酸残基的肽片段; D是含有任何氨基酸的1至12个残基的肽片段; 并且Tc是选自OH，（C 1 -C 6）烷氧基，氨基，单 - 或二 - （C 1 -C 4）烷基取代的氨基和苄基氨基的羧基末端残基。