公开(公告)号：EP0654667A1

公开(公告)日：1995-05-24

申请号：EP94306243.0

申请日：1994-08-24

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  CHROMATOFAST ,  HORIBA, LTD.

发明人： Sacks, Richard Douglas ,  Peters, Anita Jo ,  Klemp, Mark Allen ,  Holmes, Edward Jeffrey

IPC分类号： G01N30/46 ,  G01N30/40

CPC分类号： G01N30/461 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/121 ,  G01N2030/383 ,  G01N2030/402 ,  G01N2030/085

摘要： A gas chromatography system having a column comprising a precolumn and an analytical and also having a source of backflush pressure applied at the intersection of the precolumn and the analytical column. The split column arrangement enables the backflushing of high boiling point components while enabling the simultaneous analysis of lower boiling point components located in the analytical column upon the application of backflush pressure. This greatly reduces the cycle time of a chromatography system as it is unnecessary to backflush the much more slowly eluting, high boiling point components through the entire length of column and there is no need to delay backflushing until completion of analysis of the components of interest. In this manner, backflushing occurs simultaneously with analysis for a first reduction of cycle time, and the high boiling point components are backflushed through a reduced length of column for a second reduction of cycle time of the chromatography system. A thermal focusing chamber enables the trapping of the sample at the sample tube end closest to the precolumn enabling a much more concentrated sample which yields much broader peaks in the chromatogram.

摘要翻译： 一种气相色谱系统，其具有包括预柱和分析物的柱，并且还具有在预柱和分析柱的交叉点处施加反吹压力的源。 分离柱装置能够反冲洗高沸点组分，同时在施加反冲压力的同时分析位于分析柱中的低沸点组分。 这大大降低了色谱系统的循环时间，因为在整个柱的长度上不需要反冲洗更多的缓慢洗脱的高沸点组分，并且不需要延迟反吹，直到目标组分的分析完成。 以这种方式，在分析循环时间的第一次减少的同时进行反冲洗，并且将高沸点组分通过柱的减少长度反冲洗，从而色谱系统的循环时间的第二次降低。 热聚焦室使得能够在最靠近预柱的样品管端捕获样品，从而可以获得更浓缩的样品，在色谱图中产生更宽的峰。

公开(公告)号：EP0550957A1

公开(公告)日：1993-07-14

申请号：EP92310119.0

申请日：1992-11-05

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Sacks, Richard Douglas ,  Peters, Anita Jo

IPC分类号： G01N30/20

CPC分类号： G01N30/20 ,  G01N1/2214 ,  G01N1/26 ,  G01N1/40 ,  G01N30/12 ,  G01N30/24 ,  G01N30/40 ,  G01N30/466 ,  G01N30/8651 ,  G01N35/1097 ,  G01N2030/121 ,  G01N2030/122 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/385 ,  G01N2030/402 ,  G01N2030/405 ,  G01N2030/407 ,  G01N2030/623 ,  G01N2030/628 ,  G01N2030/3023 ,  G01N2030/3061

摘要： Several embodiments of gas chromatography systems are disclosed incorporating mechanical sample injection valves. The injection valves incorporate a delivery tube (126) having an outlet which is swept past the inlet of separation columns (128,130,132) to provide a short duration inlet plug into the separation columns. Carrier gas and sample gas flow is managed through valves to prevent inadvertent injection after an injection is desired and to assure that the sample is not contaminated by past sample flow. Embodiments of injections valve are described for providing inputs into several gas chromatography columns. In addition, a gas chromatography system is described in which multiple columns are used which are time multiplexed with a single detector to produce a complex combined chromatogram from the plural columns. By appropriate selection of column characteristics and injection sequence, the resulting chromatogram can provide an overlay of chromatograms which provide good resolution of all the constituents of the mixture of interest within a short analysis time.

摘要翻译： 公开了结合有机械样品注射阀的气相色谱系统的几个实施例。 喷射阀结合了输送管（126），该输送管具有被扫过分离柱（128,130,132）的入口的出口，以将短持续时间的入口塞提供到分离柱中。 载气和样气流量通过阀门进行管理，以防止在需要注入后无意注入，并确保样品未被过去的样品流量污染。 描述了注入阀的实施例用于向几个气相色谱柱提供输入。 另外，描述了一种气相色谱系统，其中使用多个柱子，其与单个检测器时间多路复用以产生来自多个柱子的复合组合色谱图。 通过适当选择色谱柱特性和进样顺序，所得色谱图可以提供色谱图叠加，在短时间内提供所关注混合物所有成分的良好分离度。

公开(公告)号：EP0661537B1

公开(公告)日：1999-12-22

申请号：EP94306176.2

申请日：1994-08-22

申请人： CHROMATOFAST

发明人： Klemp, Mark Allen ,  Peters, Anita Jo

IPC分类号： G01N30/12 ,  G01N30/40

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

公开(公告)号：EP0661537A3

公开(公告)日：1995-08-30

申请号：EP94306176.2

申请日：1994-08-22

申请人： CHROMATOFAST

发明人： Klemp, Mark Allen ,  Peters, Anita Jo

IPC分类号： G01N30/12 ,  G01N30/40

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatograph system (10) including a cold trap (12) having two portions (12a and 12b), a capillary tube (14) and a porous layer open tubular (PLOT) column (15), for substantially simultaneously trapping lower and higher boiling point gasses. The capillary tube (14) enables cold trapping of lower boiling point gasses while the PLOT column (15) enables cold trapping of higher boiling point gasses. The capillary tube interconnects at one end to an analytical column (20) and a sample gas source (26) and interconnects at its other end to a first end of the PLOT column (15). The other end of the PLOT column interconnects to a carrier gas source and a vacuum source. The capillary tube and PLOT column are both positioned within a temperature controlled environment of the cold trap. During the collection mode, the temperature control means maintains a relatively low temperature to condense the sample components. During injection of the sample from the cold trap to the analytical column, the temperature control means maintains a relatively high temperature to vaporize the sample components.

公开(公告)号：EP0661537A2

公开(公告)日：1995-07-05

申请号：EP94306176.2

申请日：1994-08-22

申请人： CHROMATOFAST

发明人： Klemp, Mark Allen ,  Peters, Anita Jo

IPC分类号： G01N30/12 ,  G01N30/40

CPC分类号： G01N30/12 ,  G01N30/40 ,  G01N2030/025 ,  G01N2030/122 ,  G01N2030/123 ,  G01N2030/128 ,  G01N2030/3046 ,  G01N2030/383 ,  G01N2030/623 ,  G01N2030/3076 ,  G01N2030/3023

摘要： A gas chromatograph system (10) including a cold trap (12) having two portions (12a and 12b), a capillary tube (14) and a porous layer open tubular (PLOT) column (15), for substantially simultaneously trapping lower and higher boiling point gasses. The capillary tube (14) enables cold trapping of lower boiling point gasses while the PLOT column (15) enables cold trapping of higher boiling point gasses. The capillary tube interconnects at one end to an analytical column (20) and a sample gas source (26) and interconnects at its other end to a first end of the PLOT column (15). The other end of the PLOT column interconnects to a carrier gas source and a vacuum source. The capillary tube and PLOT column are both positioned within a temperature controlled environment of the cold trap. During the collection mode, the temperature control means maintains a relatively low temperature to condense the sample components. During injection of the sample from the cold trap to the analytical column, the temperature control means maintains a relatively high temperature to vaporize the sample components.

摘要翻译： 一种气相色谱系统（10），包括具有两部分的冷阱，毛细管和多孔层开放管（PLOT）柱，用于基本上同时捕获较低沸点和较高沸点的气体。 毛细管能够冷藏低沸点气体，而PLOT柱可以冷却高沸点气体。 毛细管一端连接到分析柱和样品气体源，并在其另一端互连到PLOT柱的第一端。 PLOT列的另一端与载气源和真空源相互连接。 毛细管和PLOT柱均位于冷阱的温度控制环境内。 在收集模式期间，温度控制装置保持相对较低的温度以冷凝样品组分。 在将样品从冷阱注入分析柱期间，温度控制装置保持相对高的温度以蒸发样品组分。