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1.发明公开10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE 审中-公开10A-AZALIDVERBINDUNG MIT 4-GLIEDRIGER RINGSTRUKTUR
公开(公告)号：EP2287173A1
公开(公告)日：2011-02-23
申请号：EP09746388.9
申请日：2009-05-15
发明人： SUGIMOTO, Tomohiro , YAMAMOTO, Kanako , KUROSAKA, Jun , SASAMOTO, Naoki , KASHIMURA, Masato , MIURA, Tomoaki , KANEMOTO, Kenichi , YOSHIDA, Satoshi , KUMURA, Kou , AJITO, Keiichi
IPC分类号： C07H17/00 , A61K31/7052 , A61P31/04
CPC分类号： C07H17/00
摘要： A 10a-azalide compound having a 4-membered ring structure crosslinked at the 10a- and 12-positions, which is represented by the formula (I), and is effective on even Haemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).
摘要翻译： 具有由式（I）表示的在10a-和12位交联的4元环结构的10a-氮杂化合物，并且对均匀流感嗜血杆菌或红霉素抗性细菌（例如耐药性肺炎球菌和 链球菌）。
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公开(公告)号：EP1985620A1
公开(公告)日：2008-10-29
申请号：EP07706316.2
申请日：2007-02-07
发明人： SUGIMOTO, Tomohiro , YAMAMOTO, Kanako , MANAKA, Akira , OGITA, Haruhisa , KUROSAKA, Jun , KAWAMURA, Madoka , KASHIMURA, Masato , SASAMOTO, Naoki , MIURA, Tomoaki , KANEMOTO, Kenichi , OZAWA, Tomohiro , CHIKAUCHI, Ken , SHITARA, Eiki , KUBOTA, Dai
IPC分类号： C07H17/00 , C07H15/12 , A61K31/7052 , A61P31/04
CPC分类号： C07H17/00 , A61K31/7052
摘要： [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria.
[Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.摘要翻译： [目的]提供具有抗血友病流感嗜血杆菌和抗红霉素的细菌（例如耐药性肺炎球菌和链球菌）以及常规红霉素敏感细菌的新型结构的化合物。 [溶液]：由式（I）表示的新型10a-氮杂化合物，其药学上可接受的盐或其溶剂合物或其制备的中间体。 本发明的化合物对流感嗜血杆菌，抗红霉素的肺炎球菌等具有优异的抗菌活性，因此可用作感染性疾病的治疗剂。
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3.发明公开10A-AZALIDE COMPOUND CROSSLINKED AT POSITION-10A AND POSITION-12 审中-公开位置10A位置12 VERNETZTE 10A-AZALIDVERBINDUNG
公开(公告)号：EP2177526A1
公开(公告)日：2010-04-21
申请号：EP08790393.6
申请日：2008-08-06
发明人： SUGIMOTO, Tomohiro , YAMAMOTO, Kanako , KUROSAKA, Jun , SASAMOTO, Naoki , KASHIMURA, Masato , MIURA, Tomoaki , KANEMOTO, Kenichi , OZAWA, Tomohiro , CHIKAUCHI, Ken , SHITARA, Eiki
IPC分类号： C07H17/08 , A61K31/7056 , A61P31/04
CPC分类号： C07H17/00
摘要： A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).
摘要翻译： 在10a-和12位交联的新的10a-氮杂化合物，其由下式表示，并且对流感嗜血杆菌或红霉素抗性细菌（例如抗性肺炎球菌和链球菌）有效。
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公开(公告)号：EP2678349B1
公开(公告)日：2016-01-13
申请号：EP12749570.3
申请日：2012-02-20
发明人： SUGIMOTO, Tomohiro , SASAMOTO, Naoki , KUROSAKA, Jun , HAYASHI, Masato , YAMAMOTO, Kanako , KASHIMURA, Masato , USHIKI, Yasunobu , OGITA, Haruhisa , MIURA, Tomoaki , KANEMOTO, Kenichi , KUMURA, Kou , YOSHIDA, Satoshi , TAMURA, Keiji , SHITARA, Eiki
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/08
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公开(公告)号：EP3884940A1
公开(公告)日：2021-09-29
申请号：EP19888010.6
申请日：2019-11-20
发明人： TAKASHIMA, Hajime , MATSUDA, Yohei , OGATA, Yuya , SASAMOTO, Naoki , TSURUTA, Risa , USHIYAMA, Fumihito , UEKI, Kaori , TANAKA, Nozomi
IPC分类号： A61K31/422 , A61K31/454 , A61P31/04 , C07D413/06 , C07D413/14
摘要： The present invention provides a new imidazole derivative represented by the following formula or a pharmaceutically acceptable salt thereof which exhibits potent antimicrobial activity based on a LpxC-inhibiting action against gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, and their drug-resistant strains.
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公开(公告)号：EP2678349A1
公开(公告)日：2014-01-01
申请号：EP12749570.3
申请日：2012-02-20
发明人： SUGIMOTO, Tomohiro , SASAMOTO, Naoki , KUROSAKA, Jun , HAYASHI, Masato , YAMAMOTO, Kanako , KASHIMURA, Masato , USHIKI, Yasunobu , OGITA, Haruhisa , MIURA, Tomoaki , KANEMOTO, Kenichi , KUMURA, Kou , YOSHIDA, Satoshi , TAMURA, Keiji , SHITARA, Eiki
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/08
摘要： A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).
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