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公开(公告)号：EP1010761A1
公开(公告)日：2000-06-21
申请号：EP98921819.3
申请日：1998-05-26
发明人： TAKAYAMA, Masanori, Centr. Research. Laboratories , KOYAMA, Nobuto, Central Research Laboratories , SAKAI, Takeshi, Biomedical Group , KATO, Ikunoshin, Central Research Laboratories
CPC分类号： C12N9/00 , C12N9/2402 , C12Y302/01044
摘要： An isolated gene having a DNA sequence that codes for a polypeptide having the activity of degrading a sulfated fucose-containing polysaccharide or a polypeptide having an activity that is functionally equivalent to that of the above polypeptide.
摘要翻译： 一种分离的基因，其具有编码具有降解含硫酸化岩藻糖多糖的活性的多肽的DNA序列或具有与上述多肽功能等同的活性的多肽。
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公开(公告)号：EP1018336A1
公开(公告)日：2000-07-12
申请号：EP98932571.7
申请日：1998-07-16
发明人： KOBAYASHI, Eiji, Central Research Laboratories , KOYAMA, Nobuto, Central Research Laboratories , KATO, Ikunoshin, Central Research Laboratories
IPC分类号： A61K31/12
CPC分类号： C07C45/60 , A61K31/12 , A61K31/122 , C07C45/71 , C07C49/707 , C07C49/753
摘要： Carcinostatics containing as the active ingredient(s) 4-cyclopenten-1,3-dione represented by formula (I) and/or 4-hydroxy-2-cyclopentenone represented by formula (II).
摘要翻译： 制癌包含作为活性成分的（一个或多个）由式（I）表示的4-环戊烯-1,3-二酮和/或由下式表示的4-羟基-2-环戊烯酮（II）。
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公开(公告)号：EP0976717B1
公开(公告)日：2002-11-20
申请号：EP98905690.8
申请日：1998-02-26
发明人： KOYAMA, Nobuto, Central Research Laboratories , IKAI, Katsushige, Central Research Laboratories , KOBAYASHI, Eiji, Central Research Laboratories , KATO, Ikunoshin, Central Research Laboratories
IPC分类号： C07C69/28 , C07C67/08 , A61K31/215 , A61K31/235 , A61K31/23 , C07C69/013
CPC分类号： C07C69/013
摘要： Cyclopentenone derivatives having structures of 2-cyclopenten-1-one substituted with R1COO- and R2COO- at the 5- and 4-positions respectively (wherein R1 and R2 are each independently alkyl, alkenyl, or aryl), or optical isomers thereof; a process for the preparation of the derivatives by reacting 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and carcinostatic agents, apoptosis inducers and antibacterial agents containing the derivatives.
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公开(公告)号：EP1057833A1
公开(公告)日：2000-12-06
申请号：EP99903912.6
申请日：1999-02-10
发明人： SAKAI, Takeshi, Biomedical Group , KIMURA, Hitomi, Biomedical Group , KATAYAMA, Kaoru, Biomedical Group , SHIMANAKA, Kazuo, Central Research Laboratories , IKAI, Katsushige, Central Research Laboratories , KATO, Ikunoshin, Central Research Laboratories
IPC分类号： C08B37/00
CPC分类号： C08B37/00
摘要： A sulfated saccharide represented by the following formula [I] or a sulfated polysaccharide where the said sulfated saccharide is an essential component of the constituting sugar as well as a salt thereof.
(In the formula, R is OH or OSO 3 H; and n is an integer of 1-5.)摘要翻译： 由下式表示的硫酸化糖或其中所述硫酸化糖是构成糖的必需组分的硫酸化多糖及其盐。
（式中，R为OH或OSO3H，n为1-5的整数。） -
公开(公告)号：EP1050525A1
公开(公告)日：2000-11-08
申请号：EP99900318.9
申请日：1999-01-14
发明人： TATSUMI, Yoko, Central Research Laboratories , SAGAWA, Hiroaki, Central Research Laboratories , OHNOGI, Hiromu, Central Research Laboratories , KOBAYASHI, Eiji, Central Research Laboratories , WU, Hua-Kang, Central Research Laboratories , KOYAMA, Nobuto, Central Research Laboratories , IKAI, Katsushige, Central Research Laboratories , KATO, Ikunoshin, Central Research Laboratories
IPC分类号： C07C47/263 , C07C49/707 , C07C45/52 , C07C45/59 , C07C323/22 , C07D473/18 , C07D473/34 , A23L1/30 , A23L2/00 , A61K31/12 , A61K31/52
CPC分类号： A61K31/7004 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/11 , A61K31/122 , A61K31/198 , A61K31/351 , A61K31/357 , A61K31/52 , A61K31/522 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , A61K31/711 , C07C323/22 , C07C323/60 , C07C2601/08 , C07D473/00 , A23V2250/60 , A23V2250/638 , A23V2250/626
摘要： A process for producing substances capable of inducing apoptosis characterized by involving the step of heating at least one compound selected from among the following compounds (a) to (d), provided that uronic acid and/or uronic acid derivatives and compounds containing uronic acid and/or uronic acid derivatives are excluded therefrom: (a) pentoses; (b) pentose derivatives; (c) compounds containing pentoses; and (d) compounds containing pentose derivatives.
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公开(公告)号：EP0976717A1
公开(公告)日：2000-02-02
申请号：EP98905690.8
申请日：1998-02-26
发明人： KOYAMA, Nobuto, Central Research Laboratories , IKAI, Katsushige, Central Research Laboratories , KOBAYASHI, Eiji, Central Research Laboratories , KATO, Ikunoshin, Central Research Laboratories
IPC分类号： C07C69/28 , C07C67/08 , A61K31/215 , A61K31/235 , A61K31/23
CPC分类号： C07C69/013
摘要： Cyclopentenone derivative having a structure of 5-(R 1 COO-)-4-(R 2 COO-)-substituted 2-cyclopenten-1-one (R 1 and R 2 are same or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihdyroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.
摘要翻译： 具有5-（R 1 COO - ） - 4-（R 2 COO - ） - 取代的2-环戊烯-1-酮的结构的环戊烯酮衍生物（R 1和R 2相同或不同，各自为烷基，烯基或芳基）或 其光学活性物质; 通过4,5-二羟基-2-环戊烯-1-酮与相应的羧酸或其活性衍生物的反应制备环戊烯酮衍生物的方法; 和抗癌剂，细胞凋亡诱导剂和含有所述衍生物的抗菌剂。
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