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    Herstellung eines Zwischenproduktes zum Vitamin A-Acetat
    3.
    发明公开
    Herstellung eines Zwischenproduktes zum Vitamin A-Acetat 失效
    Herstellung eines Zwischenproduktes zum维生素A-Acetat。

    公开(公告)号：EP0648735A1

    公开(公告)日：1995-04-19

    申请号：EP94115331.4

    申请日：1994-09-29

    Applicant: F. HOFFMANN-LA ROCHE AG

    Inventor： Zutter, Ulrich

    IPC: C07C69/007 ,  C07C45/40 ,  C07C45/62 ,  C07C47/263 ,  C07C403/12 ,  C07C409/20

    CPC classification number: C07C403/12 ,  C07C45/40 ,  C07C45/62 ,  C07C69/007 ,  C07C2601/16 ,  C07C47/263

    Abstract: Ein neues Verfahren zur Herstellung von γ-Acetoxytiglinaldehyd, der als wichtiges Ausgangsmaterial für die Herstellung von Vitamin A-Acetat aus einem (β-Jonylidenäthyl)triphenylphosphonium-halogenid und diesem Aldehyd bekannt ist, besteht darin, dass man ein Pentenin-3-ol der Formel HC≡C-C(CH₃)(OH)-CH=C(R)₂   (II), worin beide R entweder Wasserstoff oder Methyl bedeuten, einer selektiven Ozonolyse in einem niederen Alkanol R¹OH, worin R¹ C₁₋₄-Alkyl bedeutet, unterwirft, das so erhaltene 2-Hydroxy-2-methyl-3-butinal der Formel HC≡C-C(CH₃)(OH)-CHO   (III) sowie allfällig als Nebenprodukt erhaltenes 1-Alkoxyalkyl-hydroperoxid der Formel (HOO)(R¹)CR²   (IV) zum bekannten 2-Hydroxy-2-methyl-3-butenal der Formel H₂C=CH-C(CH₃)(OH)-CHO   (V) katalytisch und (für III) selektiv hydriert und dieses auf an sich bekannte Weise in den γ-Acetoxytiglinaldehyd der Formel CH₃COO-CH₂CH=C(CH₃)-CHO   (I) überführt. Die Ueberführung des Butenals V in den Aldehyd I kann zweckmässigerweise durch die bekannten Verfahrensstufen Acetalisierung, Acetylierung, katalysierte Umlagerung und säurekatalysierte Hydrolyse durchgeführt werden.

    Abstract translation: 用于制备γ-乙酰氧基三烯醛的新方法，其被称为从（β-亚炔基乙基）三苯基鏻卤化物和该醛制备维生素A乙酸酯的重要起始原料，其在于将戊烯-3-醇 配方HC标识CC（CH 3）（OH）-CH = C（R）2（II）其中两个R 5是氢或甲基，以在低级链烷醇R 1 OH中进行选择性臭氧分解，其中R 1是C1- 氢化由式得到的2-羟基-2-甲基-3-丁炔，由式HC（CH 3）（OH）-CHO（III）和式（HOO）的1-烷氧基烷基氢过氧化物（R） （CH 3）（OH）-CHO（V）的已知2-羟基-2-甲基-3-丁烯醛作为副产物可能获得的CR 2（IV） 并且以本身已知的方式将其转化为式CH 3 COO-CH 2 CH = C（CH 3）-CHO（I）的γ-乙酰氧基三醛。 丁烯醛V转化为醛I可以方便地通过已知的方法步骤缩醛化，乙酰化，催化重排和酸催化水解来进行。

    OPEN-CHAIN TERPENE COMPOUND
    5.
    发明公开
    OPEN-CHAIN TERPENE COMPOUND 失效
    OFFENKETTIGE TERPENVERBINDUNG。

    公开(公告)号：EP0455822A1

    公开(公告)日：1991-11-13

    申请号：EP90917530.9

    申请日：1990-11-29

    Applicant: Mitsubishi Chemical Corporation

    Inventor： TAKAYANAGI, Hisao ,  KITANO, Yasunori ,  MORINAKA, Yasuhiro

    IPC: C07C43/315 ,  C07C47/263 ,  C07C47/277 ,  C07C69/025 ,  C07C69/732 ,  C07C69/734 ,  C07D307/20 ,  C07D309/12

    CPC classification number: C07D309/12 ,  C07C43/315 ,  C07C47/263 ,  C07C47/277 ,  C07C69/734 ,  C07D307/20

    Abstract: A novel open-chain terpene compound useful as an intermediate for sarcophytol A having a resitance to a carcinogenesis and an antitumor activity and represented by general formula (I), wherein R¹ is a hydrogen atom, a 1-alkoxyalkyl group, a tetrahydrofuryl group, a tetrahydropyranyl group or an acyl group, R² is -CHO, -CH₂OR³ or (a), wherein R³ is a hydrogen atom, a 1-alkoxyalkyl group, a tetrahydrofuryl group, a tetrahydropyranyl group or an acyl group, R⁴ is an alkyl group having 1 to 4 carbon atoms, provided that R¹ and R³ are not simultaneously the same substituents and, when R¹ is a hydrogen atom, R³ is neither an acetyl group nor a tetrahydropyranyl group and, when R² is a group represented by formula (a), R¹ is not a hydrogen atom.

    Abstract translation: 萜烯cpds。 式（I）的化合物是新的：在（I）中R1 = H，1-烷氧基烷基，四氢呋喃基，四氢吡喃基或酰基; R2 = CHO，CH2OR3或gp。 式（a）的化合物：R3 = H，1-烷氧基烷基，四氢呋喃基，四氢吡喃基或酰基; R4 = 1-4C烷基; 条件是R1和R3不都相同，（i）当R1 = H时，R3不是乙酰基或四氢吡喃基，（ii）当R2 = gp时。 （a）然后R1不是H.

    Hydroformylation process
    6.
    发明公开
    Hydroformylation process 失效
    Hydroformylierungsverfahren。

    公开(公告)号：EP0303060A1

    公开(公告)日：1989-02-15

    申请号：EP88111155.3

    申请日：1988-07-12

    Applicant: KURARAY CO., LTD.

    Inventor： Omatsu, Toshihiro ,  Tokitoh, Yasuo ,  Yoshimura, Noriaki

    IPC: C07C45/49 ,  C07C47/263 ,  C07C47/12

    CPC classification number: C07C47/12 ,  C07C45/49 ,  C07C47/263

    Abstract: A hydroformylation process is provided which comprises reacting a compound of the general formula
        CH₂=CH-CH₂-A-CH₂-X
    wherein X is a hydroxyl or formyl group and A is a group of the formula
        -(CH₂) n - or -(CH₂) m -CH=CH-
    in which n is an integer of 3-8 and m is an integer of 0-5, with a mixture of hydrogen and carbon monoxide in the presence of a rhodium compound and a specific tris(substituted phenyl) phosphite

    Abstract translation: 提供加氢甲酰化方法，其包括使通式CH 2 = CH-CH 2 -A-CH 2 -X（其中X是羟基或甲酰基）和A是式 - （CH 2）n - 或 - （ CH 2）m -CH = CH-，其中n为3-8的整数，m为0-5的整数，与氢和一氧化碳的混合物在铑化合物和特定的三（取代的苯基 ）亚磷酸盐

    Optically active or racemic aminal derivatives, process for preparing same and for converting same to alpha-hydroxyaldehydes
    7.
    发明公开
    Optically active or racemic aminal derivatives, process for preparing same and for converting same to alpha-hydroxyaldehydes 失效
    旋光或外消旋氨醛，它们的制备方法，将其转化成α-羟基醛。

    公开(公告)号：EP0011417A1

    公开(公告)日：1980-05-28

    申请号：EP79302419.1

    申请日：1979-11-02

    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

    Inventor： Mukaiyama, Teruaki ,  Sakito, Yoji ,  Asami, Masatoshi

    IPC: C07C47/27 ,  C07C47/19 ,  C07C47/198 ,  C07C47/263 ,  C07C45/56 ,  C07D487/04

    CPC classification number: C07D487/04 ,  C07C45/27 ,  C07C45/562 ,  C07C47/263 ,  C07C47/27 ,  C07C47/277

    Abstract: An optically active or racemic a-hydroxyaldehyde of formula
    wherein R, represents a C 6 -C 14 aryl group, C 1 -C 10 alkyl group, C 1 -C 10 alkenyl group, C 2 -C 10 alkynyl group, C 2 -C 14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R : represents a C 1 -C 10 alkyl group, C 1 -C 10 alkenyl group, C 1 -C 10 alkynyl group, C 7 -C 14 aralkyl group, C 6 -C 14 aryl group or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals and can be prepared by reacting an optically active or racemic compound of formula
    wherein A represents a C 6 -C 14 aryl group or a C 1 -C 4 alkyl or alkoxy group- or halogen-substituted C 6 -C 14 aryl group and R is as defined above, with a Grignard reagent, and thereafter hydrolyzing the reaction product.
    The compound of formula (1) above can for example be prepared by reaction of an arylglyoxal with an optically active or racemic 2-iN-substituted aminomethyl)pyrroiidine or by reacting a Grignard reagent with an optically active or racemic. diazabicyclooctane derivative which itself can be prepared from a glyoxylate ester or glyoxylate ester hemiacetal and a 2(-N-substituted aminomethyl)pyrrolidine.

    METHOD FOR PREPARING METHYLOL ALKANAL
    8.
    发明公开
    METHOD FOR PREPARING METHYLOL ALKANAL 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON METHYLOLALKANAL

    公开(公告)号：EP2910542A1

    公开(公告)日：2015-08-26

    申请号：EP14830347.2

    申请日：2014-07-21

    Applicant: LG Chem, Ltd.

    Inventor： EOM, Sung Shik ,  KIM, Min Soo ,  KIM, Tae Yun ,  KO, Dong Hyun

    IPC: C07C45/75 ,  C07C45/86 ,  C07C47/263

    CPC classification number: C07C45/75 ,  C07C45/86 ,  C07C47/263

    Abstract: Disclosed is a method of preparing methylol alkanal. According to the present invention, a yield of methylol alkanal may be improved without using formaldehyde in an excess amount of a theoretical minimum molar ratio or more, formaldehyde wastewater may be reduced, and the amount of formaldehyde remainder, which may act as a hydrogenation catalyst poison, comprised in the methylol alkanal is decreased when the prepared methylol alkanal is hydrogenated resulting in improvement in efficiency of the hydrogenation.

    Abstract translation: 公开了制备羟甲基链烷醛的方法。 根据本发明，可以在不使用过量的理论最小摩尔比或更多的甲醛的情况下改善羟甲基链烷酸的收率，甲醛废水可以降低，甲醛剩余量可以用作氢化催化剂 当制备的羟甲基链烷醛被氢化时，包含在羟甲基链烷醛中的毒素降低，从而提高氢化效率。

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