公开(公告)号：EP1424392A1

公开(公告)日：2004-06-02

申请号：EP02762956.7

申请日：2002-09-02

申请人： Takeda Chemical Industries, Ltd.

发明人： HINUMA, Shuji ,  FUKUSUMI, Shoji ,  KOMATSU, Hidetoshi ,  FUJII, Ryo ,  KITADA, Chieko ,  HOSOYA, Masaki ,  HABATA, Yugo ,  HARADA, Masataka ,  NOGUCHI, Yuko

IPC分类号： C12N15/12 ,  C07K14/47 ,  A61K38/17 ,  A61K39/395 ,  A61P25/00 ,  A61P43/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/50 ,  G01N33/15

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Secretory proteins comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by, for example, SEQ ID NO: 23 are useful physiologically active substances binding to AQ27 receptor.

摘要翻译： 包含与例如SEQ ID NO：23表示的氨基酸序列相同或基本相同的氨基酸序列的分泌蛋白质是与AQ27受体结合的有用的生理活性物质。

公开(公告)号：EP1283260A1

公开(公告)日：2003-02-12

申请号：EP01921950.0

申请日：2001-04-20

申请人： Takeda Chemical Industries, Ltd.

发明人： ITOH, Yasuaki ,  SUZUKI, Nobuhiro ,  NISHI, Kazunori ,  KIZAWA, Hideki ,  HARADA, Masataka ,  OGI, Kazuhiro

IPC分类号： C12N15/09 ,  C07K14/65 ,  C07K16/26 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C12Q1/68 ,  C12P21/02 ,  C12P21/08 ,  A61K38/17 ,  A61K38/28 ,  A61K38/30 ,  A61K39/395 ,  A61K45/00

CPC分类号： G01N33/74 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K39/00 ,  C07K14/575 ,  C07K14/64 ,  C07K14/65 ,  C07K16/26 ,  G01N2333/62 ,  G01N2333/64

摘要： The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:8 (B chain), (3) a polypeptide wherein the A and B chains are bonded to each other via disulfide bonds (2 chains) or its salt, (4) DNAs encoding the same, etc.
These polypeptides and DNAs encoding the same can be used for the diagnosis, treatment, prevention, etc. for diseases, including abnormalities (e.g., diabetes mellitus, etc.) in metabolic regulation (sugar metabolism, lipid metabolism, etc.) of energy sources such as carbohydrates.

摘要翻译： 本发明涉及（1）含有与SEQ ID NO：7（A链）所示氨基酸序列相同或基本相同的氨基酸序列的多肽，（2）含有相同或基本相同氨基的多肽 酸序列作为由SEQ ID NO：8（B链）表示的氨基酸序列，（3）其中A和B链通过二硫键（2链）或其盐彼此键合的多肽，（4）DNA 这些多肽和编码它们的DNA可以用于疾病的诊断，治疗，预防等，包括代谢调节（糖代谢，脂质代谢，糖代谢等）中的异常（例如糖尿病等） 等等）的能源，如碳水化合物。

公开(公告)号：EP1479768A1

公开(公告)日：2004-11-24

申请号：EP03705107.5

申请日：2003-02-13

申请人： Takeda Chemical Industries, Ltd.

发明人： HINUMA, Shuji ,  HOSOYA, Masaki ,  ITO, Yasuaki ,  KOBAYASHI, Makoto ,  TANAKA, Hideyuki ,  OKUBO, Shoichi ,  FUJII, Ryo ,  KIZAWA, Hideki ,  KAWAMATA, Yuji ,  OGI, Kazuhiro ,  HARADA, Masataka ,  FUKUSUMI, Shoji

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/00 ,  A61P35/00 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K2319/60 ,  G01N2333/726 ,  G01N2500/00

摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.

摘要翻译： 通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和（2）脂肪酸或类花生酸，化合物 或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。

公开(公告)号：EP0862573A1

公开(公告)日：1998-09-09

申请号：EP96935359.0

申请日：1996-10-18

申请人： Takeda Chemical Industries, Ltd.

发明人： FURUYA, Shuichi ,  CHOH, Nobuo ,  HARADA, Masataka ,  SASAKI, Satoshi

IPC分类号： C07D495

CPC分类号： C07D495/04

摘要： The present thienopyrimidine derivatives of formula (I) and compositions having ganodotropin-releasing hormone antagonistic activity are useful as propylactics or therapeutic agents for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g., prostatic cancer, uterine cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g., a preganancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals; and as agents for promoting spawning in fish.