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31 条记录 (耗时 0.026 秒)

    USE OF PEPTIDE
    2.
    发明公开
    USE OF PEPTIDE 审中-公开
    VERWENDUNG VON PEPTID LIGANDENFÜRG-PROTEIN GEKOPPELTE REZEPTOREN

    公开(公告)号：EP1230928A1

    公开(公告)日：2002-08-14

    申请号：EP00976321.0

    申请日：2000-11-17

    申请人： Takeda Chemical Industries, Ltd.

    发明人： KITADA, Chieko ,  MATSUMOTO, Hirokazu ,  HINUMA, Shuji

    IPC分类号： A61K38/17 ,  A61P5/40 ,  A61P3/04

    CPC分类号： A61K38/1709

    摘要： The ligand polypeptides of the present invention have activity to regulate CRH secretion, and thus are useful as CRH secretion regulators for the relief, prevention or treatment of various diseases related to CRH secretion, such as hypoaldosteronism, hypocortisolemia, secondary and chronic adrenocorticism, Addison's disease (weakness, nausea, pigmentation, hypogonadism, alopecia, and hypotension), adrenal dysfunction, and obesity, and also as analgesics.

    摘要翻译： 本发明的配体多肽具有调节CRH分泌的活性，因此可用作CRH分泌调节剂用于缓解，预防或治疗与CRH分泌有关的各种疾病，例如低醛固酮增多症，低皮质醇降低症，继发性和慢性肾上腺皮质激素，艾迪生病 （虚弱，恶心，色素沉着，性腺机能减退，脱发和低血压），肾上腺功能障碍和肥胖，以及止痛药。

    USE OF PEPTIDE
    3.
    发明公开
    USE OF PEPTIDE 审中-公开
    PEPTIDVERWENDUNG

    公开(公告)号：EP1142580A1

    公开(公告)日：2001-10-10

    申请号：EP99961301.1

    申请日：1999-12-22

    申请人： Takeda Chemical Industries, Ltd.

    发明人： MATSUMOTO, Hirokazu ,  KITADA, Chieko ,  HINUMA, Shuji

    IPC分类号： A61K38/17

    CPC分类号： A61K38/2257

    摘要： The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secresion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.

    摘要翻译： 本发明涉及G蛋白偶联受体蛋白识别为配体的肽的用途。 由于本发明的配体多肽对催产素分泌具有刺激作用，因此作为改善，保存或治疗与催产素分泌有关的各种疾病如子宫惯性，失声性出血，胎盘排出，亚溶液等的药物是有用的。

    NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN, ITS DNA AND LIGAND THEREOF
    4.
    发明公开
    NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN, ITS DNA AND LIGAND THEREOF 审中-公开
    灭菌剂G-PROTEIN GEKOPPELTES REZEPTORPROTEIN，DESSEN DNA UND LIGAND

    公开(公告)号：EP1132405A1

    公开(公告)日：2001-09-12

    申请号：EP99972224.2

    申请日：1999-11-11

    申请人： Takeda Chemical Industries, Ltd.

    发明人： WATANABE, Takuya ,  KIKUCHI, Kuniko ,  TERAO, Yasuko ,  SHINTANI, Yasushi ,  HINUMA, Shuji ,  FUKUSUMI, Shoji ,  FUJII, Ryo ,  HOSOYA, Masaki ,  KITADA, Chieko

    IPC分类号： C07K14/705 ,  C12N15/12 ,  C12P21/02 ,  C07K16/28 ,  A61K39/395 ,  G01N33/50 ,  C07K2/00 ,  A61K38/00

    CPC分类号： G01N33/566 ,  C07K14/723

    摘要： The present invention relates to a novel polypeptide, its partial peptide or salt thereof, a method for manufacturing the polypeptide, a receptor of the polypeptide, a pharmaceutical composition comprising the polypeptide or the like, an antibody to the polypeptide, a method/kit for screening a compound that promotes or inhibits an activity of the polypeptide or salt thereof, a compound that can be obtained by the screening, a pharmaceutical composition comprising the compound, and the like.
    The polypeptide, its partial peptide or the like of the present invention can be used, for example, as a therapeutic agent for nervous disease, a promoting agent for somatostatin secretion and the like. Further, the antibody of the present invention can be used for a quantification of the polypeptide of the present invention in a sample solution. Furthermore, the polypeptide of the present invention is useful for a reagent for screening a compound that promotes or inhibits the activity of the polypeptide of the present invention.

    摘要翻译： 本发明涉及新的多肽，其部分肽或其盐，制备多肽的方法，多肽的受体，包含多肽的药物组合物，多肽的抗体，多肽的抗体， 筛选促进或抑制多肽或其活性的化合物，可通过筛选获得的化合物，包含该化合物的药物组合物等。 本发明的多肽，其部分肽等可以用作神经疾病的治疗剂，生长抑素分泌促进剂等。 此外，本发明的抗体可以用于在样品溶液中定量本发明的多肽。 此外，本发明的多肽可用于筛选促进或抑制本发明多肽活性的化合物的试剂。

    ANTIBODY AND USE OF THE SAME
    5.
    发明公开
    ANTIBODY AND USE OF THE SAME 有权
    抗生素GEGEN METASTIN UNDSEN VERWENDUNG ZUR DIAGNOSE VON SCHWANGERS AKTI

    公开(公告)号：EP1428835A1

    公开(公告)日：2004-06-16

    申请号：EP02765578.6

    申请日：2002-09-18

    申请人： Takeda Chemical Industries, Ltd.

    发明人： MATSUMOTO, Hirokazu ,  HORIKOSHI, Yasuko ,  KITADA, Chieko ,  OHTAKI, Tetsuya

    IPC分类号： C07K16/18 ,  A61K39/395 ,  C12N5/16 ,  C12P21/08 ,  G01N33/53

    CPC分类号： G01N33/689 ,  C07K16/18 ,  G01N33/6857 ,  G01N2800/368

    摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same.
    Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.

    摘要翻译： 本发明的目的在于提供一种抗体，通过该抗体可以高灵敏度特异性定量分析蛋白或其衍生物，使用抗体检测/定量转移癌或其衍生物的方法，以及诊断剂（例如，怀孕诊断） 一样。 具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/ 使用抗体定量分析或其衍生物，以及使用该抗体的诊断剂。

    NOVEL G PROTEIN-COUPLED RECEPTOR PROTEINS, DNAS THEREOF AND LIGANDS TO THE SAME
    8.
    发明公开
    NOVEL G PROTEIN-COUPLED RECEPTOR PROTEINS, DNAS THEREOF AND LIGANDS TO THE SAME 有权
    NEUE G蛋白 - GEKOPPELTE REZEPTOR蛋白，DNAS DAVON UND LIGANDENFÜRDIESE

    公开(公告)号：EP1126028A1

    公开(公告)日：2001-08-22

    申请号：EP99949421.4

    申请日：1999-10-26

    申请人： Takeda Chemical Industries, Ltd.

    发明人： WATANABE, Takuya ,  TERAO, Yasuko ,  SHINTANI, Yasushi ,  OHTAKI, Tetsuya ,  KANEHASHI, Kimiko ,  KITADA, Chieko

    IPC分类号： C12N15/12 ,  C07K14/705 ,  C07K16/28 ,  C12P21/08 ,  C12Q1/68 ,  A61K38/17 ,  A61P35/00 ,  A61P15/06

    CPC分类号： G01N33/566 ,  A61K38/00 ,  C07K14/705 ,  G01N2333/726 ,  G01N2500/02

    摘要： The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
    The rat cerebellum-derived and human brain-derived G protein coupled receptor proteins and the like are useful: (1) for determination of a ligand to the receptor protein of the present invention (ligand peptide of the present invention) (agonist), (2) as an agent for the prevention and/or treatment of diseases associated with dysfunction of the G protein coupled receptor protein of the present invention, (3) as a genetic diagnostic agent, (4) for quantification of a ligand to the G protein coupled receptor protein of the present invention, (5) for screening of a compound (agonist, antagonist, etc.) that alters the binding property between the G protein coupled receptor protein of the present invention and a ligand (ligand peptide of the present invention), (6) as a agent for the prevention and/or treatment of various diseases, comprising a compound (agonist, antagonist, etc.) that alters the binding property between the G protein coupled receptor protein of the present invention and a ligand (ligand peptide of the present invention), (7) for quantification of the receptor protein, its partial peptide or salts of the present invention, (8) for neutralization by antibodies to the receptor protein, its partial peptide or salts of the present invention and (9) for preparation of a non-human animal bearing the DNA encoding the G protein coupled receptor protein of the present invention.

    摘要翻译： 本发明涉及大鼠小脑衍生和人类脑源性G蛋白偶联受体蛋白或其盐，其部分肽，酰胺，酯或其盐，配体，用于筛选化合物改变结合的方法/试剂盒 配体和G蛋白偶联受体蛋白质之间的性质，通过筛选获得的化合物，以及G蛋白偶联受体蛋白质的抗体。 大鼠小脑衍生和人类脑衍生的G蛋白偶联受体蛋白质等可用于：（1）用于测定本发明的受体蛋白质的配体（本发明的配体肽）（激动剂），（激动剂），（ 2）作为用于预防和/或治疗与本发明的G蛋白偶联受体蛋白质功能障碍相关的疾病的试剂，（3）作为遗传诊断剂，（4）用于定量G蛋白的配体 本发明的偶联受体蛋白质，（5）用于筛选改变本发明的G蛋白偶联受体蛋白质与配体（本发明的配体肽）之间的结合性的化合物（激动剂，拮抗剂等） ），（6）作为预防和/或治疗各种疾病的药剂，其包含改变本发明的G蛋白偶联受体蛋白质与本发明的G蛋白偶联受体蛋白质之间的结合性质的化合物（激动剂，拮抗剂等） 配体（本发明的配体肽），（7）定量本发明的受体蛋白质，其部分肽或盐，（8）用于通过受体蛋白质的抗体中和的抗体，其部分肽或本发明的盐 发明和（9）用于制备携带编码本发明的G蛋白偶联受体蛋白质的DNA的非人动物。

    ANTIBODY AGAINST $g(b)-AMYLOID OR DERIVATIVE THEREOF AND USE THEREOF
    9.
    发明公开
    ANTIBODY AGAINST $g(b)-AMYLOID OR DERIVATIVE THEREOF AND USE THEREOF 失效
    ANTIKÖRPERGEGEN -g（b）-AMYLOID ODER DERIVATE DAVON UND SEINE VERWENDUNG。

    公开(公告)号：EP0683234A1

    公开(公告)日：1995-11-22

    申请号：EP94904758.3

    申请日：1994-01-24

    申请人： Takeda Chemical Industries, Ltd.

    发明人： SUZUKI, Nobuhiro ,  ODAKA, Asano ,  KITADA, Chieko

    IPC分类号： C12P21/08 ,  C07K15/06 ,  C07K15/28

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K16/18

    摘要： Novel antibodies useful because of having the binding specificity for β-amyloid or derivatives thereof with β-amyloid acting as an immunogen, or monoclonal antibodies which recognize the N-terminus, C-terminus and central portion, respectively, of β-amyloid. The combination of these antibodies provides an assay method whereby β-amyloid can be specifically determined with a high sensitivity. This method is useful for diagnosing diseases in which β-amyloid or a derivative thereof participates, such as Alzheimer's disease, and the antibodies are useful for developing preventive or therapeutic agents for Alzheimer's disease.

    摘要翻译： 由于具有作为免疫原的β-淀粉样蛋白对β淀粉样蛋白或其衍生物具有结合特异性的新型抗体，或分别识别β-淀粉样蛋白的N末端，C-末端和中心部分的单克隆抗体。 这些抗体的组合提供了一种测定方法，由此可以高灵敏度特异性地测定β-淀粉样蛋白。 该方法可用于诊断其中β-淀粉样蛋白或其衍生物如阿尔茨海默氏病参与的疾病，并且该抗体可用于开发阿尔茨海默氏病的预防或治疗剂。

    ANTIBODY AGAINST BETA-AMYLOID OR THEIR DERIVATIVE AND USE THEREOF
    10.
    发明授权
    ANTIBODY AGAINST BETA-AMYLOID OR THEIR DERIVATIVE AND USE THEREOF 失效
    单克隆抗体抗β淀粉样蛋白或其衍生物及其用途

    公开(公告)号：EP0683234B2

    公开(公告)日：2007-06-06

    申请号：EP94904758.3

    申请日：1994-01-24

    申请人： Takeda Chemical Industries, Ltd.

    发明人： SUZUKI, Nobuhiro ,  ODAKA, Asano ,  KITADA, Chieko

    IPC分类号： C12P21/08 ,  C07K16/06 ,  C07K16/28 ,  C12R1/91

    CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K16/18

    摘要： Novel antibodies useful because of having the binding specificity for beta -amyloid or derivatives thereof with beta -amyloid acting as an immunogen, or monoclonal antibodies which recognize the N-terminus, C-terminus and central portion, respectively, of beta -amyloid. The combination of these antibodies provides an assay method whereby beta -amyloid can be specifically determined with a high sensitivity. This method is useful for diagnosing diseases in which beta -amyloid or a derivative thereof participates, such as Alzheimer's disease, and the antibodies are useful for developing preventive or therapeutic agents for Alzheimer's disease.