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1.发明公开
公开(公告)号：EP1227105A1
公开(公告)日：2002-07-31
申请号：EP00970212.7
申请日：2000-10-31
发明人： HINUMA, Shuji , KAWAMATA, Yuji , FUKUSUMI, Shoji , FUJII, Ryo
摘要： The present invention relates to polypeptides characterized by containing an amino acid sequence that is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or amides, esters or salts thereof, which are useful for developing pharmaceuticals such as GH secretion controlling agents; DNAs encoding these polypeptides, or amides, esters or salts thereof; a method/kit for screening a compound capable of changing the binding properties of these polypeptides to GHSR; etc.
摘要翻译： 本发明涉及多肽，其特征在于含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列或其酰胺，酯或盐，其可用于开发药物如 GH分泌控制剂; 编码这些多肽的DNA或其酰胺，酯或其盐; 用于筛选能够将这些多肽的结合特性改变为GHSR的化合物的方法/试剂盒; 等等
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2.发明公开NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN, ITS DNA AND LIGAND THEREOF 审中-公开灭菌剂G-PROTEIN GEKOPPELTES REZEPTORPROTEIN，DESSEN DNA UND LIGAND
公开(公告)号：EP1132405A1
公开(公告)日：2001-09-12
申请号：EP99972224.2
申请日：1999-11-11
发明人： WATANABE, Takuya , KIKUCHI, Kuniko , TERAO, Yasuko , SHINTANI, Yasushi , HINUMA, Shuji , FUKUSUMI, Shoji , FUJII, Ryo , HOSOYA, Masaki , KITADA, Chieko
IPC分类号： C07K14/705 , C12N15/12 , C12P21/02 , C07K16/28 , A61K39/395 , G01N33/50 , C07K2/00 , A61K38/00
CPC分类号： G01N33/566 , C07K14/723
摘要： The present invention relates to a novel polypeptide, its partial peptide or salt thereof, a method for manufacturing the polypeptide, a receptor of the polypeptide, a pharmaceutical composition comprising the polypeptide or the like, an antibody to the polypeptide, a method/kit for screening a compound that promotes or inhibits an activity of the polypeptide or salt thereof, a compound that can be obtained by the screening, a pharmaceutical composition comprising the compound, and the like.
The polypeptide, its partial peptide or the like of the present invention can be used, for example, as a therapeutic agent for nervous disease, a promoting agent for somatostatin secretion and the like. Further, the antibody of the present invention can be used for a quantification of the polypeptide of the present invention in a sample solution. Furthermore, the polypeptide of the present invention is useful for a reagent for screening a compound that promotes or inhibits the activity of the polypeptide of the present invention.摘要翻译： 本发明涉及新的多肽，其部分肽或其盐，制备多肽的方法，多肽的受体，包含多肽的药物组合物，多肽的抗体，多肽的抗体， 筛选促进或抑制多肽或其活性的化合物，可通过筛选获得的化合物，包含该化合物的药物组合物等。 本发明的多肽，其部分肽等可以用作神经疾病的治疗剂，生长抑素分泌促进剂等。 此外，本发明的抗体可以用于在样品溶液中定量本发明的多肽。 此外，本发明的多肽可用于筛选促进或抑制本发明多肽活性的化合物的试剂。
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公开(公告)号：EP1479768A1
公开(公告)日：2004-11-24
申请号：EP03705107.5
申请日：2003-02-13
发明人： HINUMA, Shuji , HOSOYA, Masaki , ITO, Yasuaki , KOBAYASHI, Makoto , TANAKA, Hideyuki , OKUBO, Shoichi , FUJII, Ryo , KIZAWA, Hideki , KAWAMATA, Yuji , OGI, Kazuhiro , HARADA, Masataka , FUKUSUMI, Shoji
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12Q1/02 , C12Q1/68 , G01N33/15
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K2319/60 , G01N2333/726 , G01N2500/00
摘要： By using (1) a G protein-coupled receptor protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or its salt and (2) a fatty acid or an eicosanoid, a compound or its salt that can change the binding properties of the receptor protein or its salt to the fatty acid or the eicosanoid can be screened efficiently.
摘要翻译： 通过使用（1）具有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和（2）脂肪酸或类花生酸，化合物 或者可以有效地筛选能够将受体蛋白质或其盐与脂肪酸或类花生酸形成的结合性质改变的盐。
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4.发明公开LIGAND POLYPEPTIDE FOR THE G PROTEIN-COUPLED RECEPTOR FROM HUMAN PITUITARY GLANDS 失效和多肽配体的G蛋白偶联受体人垂体腺
公开(公告)号：EP0981616A1
公开(公告)日：2000-03-01
申请号：EP98917693.8
申请日：1998-04-27
发明人： HINUMA, Shuji , FUKUSUMI, Shoji
IPC分类号： C12N15/12 , C07K14/47 , C07K14/72 , C12N1/21 , C12N5/10 , C07K16/18 , C12Q1/68 , G01N33/52 , A61K38/00
CPC分类号： C07K14/723 , A01K2217/05 , A61K38/00 , C07K14/47
摘要： The present invention relates to the murine-derived ligand polypeptide for the G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds, and (3) production of non-human transgenic animals or non-human knockout animals for analyzing a function of the genes.
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5.发明公开
公开(公告)号：EP1424392A1
公开(公告)日：2004-06-02
申请号：EP02762956.7
申请日：2002-09-02
发明人： HINUMA, Shuji , FUKUSUMI, Shoji , KOMATSU, Hidetoshi , FUJII, Ryo , KITADA, Chieko , HOSOYA, Masaki , HABATA, Yugo , HARADA, Masataka , NOGUCHI, Yuko
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , A61K39/395 , A61P25/00 , A61P43/00 , C07K16/18 , C12P21/02 , G01N33/50 , G01N33/15
摘要： Secretory proteins comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by, for example, SEQ ID NO: 23 are useful physiologically active substances binding to AQ27 receptor.
摘要翻译： 包含与例如SEQ ID NO：23表示的氨基酸序列相同或基本相同的氨基酸序列的分泌蛋白质是与AQ27受体结合的有用的生理活性物质。
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6.发明公开NOVEL PEPTIDE, PROCESS FOR THE PRODUCTION OF THE SAME, AND USE OF THE SAME 失效与肽或CORTISTATIN-生长抑素活性，方法及其及其用途
公开(公告)号：EP0911393A1
公开(公告)日：1999-04-28
申请号：EP97924324.3
申请日：1997-06-05
发明人： HINUMA, Shuji , FUKUSUMI, Shoji , KITADA, Chieko
IPC分类号： C12N15/00 , C07K14/655 , C07K16/26 , C12N1/21 , C12P21/02 , A61K38/10 , A61K38/31 , G01N33/53 , G01N33/566
CPC分类号： C07K14/575 , A61K38/00 , C07K14/655 , Y10S514/806 , Y10S930/16
摘要： The peptides and precursors thereof, inclusive salts thereof, of the present invention are useful as a pharmaceutical composition, for example as therapeutic or prophylactic agents for hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. The DNAs coding for the peptides or precursors of the invention are useful as a pharmaceutical composition, for example as agents for the gene therapy or prevention of hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the like, hormone secretion inhibitors, tumor growth inhibitors, neural activity or sleep modulators, etc. Furthermore, the DNAs coding for the peptides or precursors of the invention are useful as agents for the gene diagnosis of various diseases, for example, hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer, etc. The antibodies against the peptides, precursors or salts of the invention can be used for assaying the peptides, precursors or salts of the invention in test solutions. The peptides, precursors or salts of the invention are useful as reagents for screening for compounds, or salts thereof, capable of modifying the binding of the peptides, precursors or sets of the invention to certain receptors.
摘要翻译： 肽和它们的前体，包括它们的盐，本发明的，是作为药物组合物是有用的，例如作为用于激素的肿瘤，肢端肥大症，巨人症，痴呆症，胃溃疡等，激素分泌抑制剂治疗或预防剂， 肿瘤生长抑制剂，神经活动或睡眠调节剂，等等。编码本发明的肽或前体的DNA是作为药物组合物是有用的，例如作为用于基因治疗或预防激素产生肿瘤剂，肢端肥大症，巨人症， 痴呆，胃溃疡等，激素分泌抑制剂，肿瘤生长抑制剂，神经活动或睡眠调节剂，等。此外更多，用于本发明的肽或前体的DNA编码如对各种疾病的基因诊断试剂是有用的，用于 例如，激素的肿瘤，肢端肥大症，巨人症，痴呆症，胃溃疡等针对所述肽的抗体，precurso RS或本发明的盐可以用于测定本发明的肽，前体或盐在试验溶液。 的肽，前体或本发明的盐是作为试剂用于筛选化合物，或其盐，能够改变所述肽，前体或套发明某些受体的结合是有用的。
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7.发明公开LIGAND POLYPEPTIDES FOR THE G-PROTEIN-COUPLED RECEPTOR PROTEIN, THEIR PRODUCTION AND USE 失效LIGAND多肽垂体的G蛋白偶联受体蛋白质，其生产和使用
公开(公告)号：EP0870020A2
公开(公告)日：1998-10-14
申请号：EP96943306.0
申请日：1996-12-26
发明人： HINUMA, Shuji , HABATA, Yugo , KAWAMATA, Yuji , HOSOYA, Masaki , FUJII, Ryo , FUKUSUMI, Shoji , KITADA, Chieko
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
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公开(公告)号：EP1403281A1
公开(公告)日：2004-03-31
申请号：EP02736088.2
申请日：2002-06-13
发明人： HINUMA, Shuji , FUJII, Ryo , FUKUSUMI, Shoji , MORI, Masaaki , YOSHIDA, Hiromi
IPC分类号： C07K14/47 , C07K14/705 , C12N15/12 , C12N1/21 , C12N1/19 , C12N5/10 , C12P21/02 , C07K16/18 , C07K16/28 , C12Q1/68 , A61K38/17 , A61K39/395 , G01N33/53 , G01N33/577
CPC分类号： G01N33/566 , C07K14/47 , C07K14/705 , C07K14/723 , G01N33/92
摘要： A GPR7 ligand containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:1 wherein the N-terminal amino acid residue may optionally be brominated, is useful in developing a receptor-binding assay system with the use of the GPR7 expression system, in screening a candidate compound for a drug such as an antiobestic, etc.
摘要翻译： 与GPR7阿片样生长抑素样受体蛋白结合的肽（I）（人，小鼠，大鼠和牛来源的六个序列（GPR7配体A至F）），其结合GPR7阿片样生长抑素样受体蛋白，以及酰胺，酯和盐 的这些肽及其在N-末端氨基酸溴化的衍生物是新的。 还包括（1）含有（I）部分序列的肽的独立权利要求。 （2）（I）的前体肽; （3）编码（I）的全部或部分的多核苷酸; （4）含有这些多核苷酸的表达载体; （5）由表达载体转化的宿主; （6）通过由表达载体转化的宿主细胞的培养物制备（I）或其部分肽或前体; （7）抗体全部或部分（I）; （8）含有肽（I），其部分肽，编码它们的多核苷酸或识别它们的抗体的药物组合物; （9）含有编码全部或部分（I）的多核苷酸或识别全部或部分（I）的抗体的诊断试剂; （10）筛选化合物（I）与GPR7的结合或改变（I）的表达程度的化合物; （11）通过筛选方法鉴定的化合物; （12）含有这些化合物的药物组合物; （13）进行筛选方法的试剂盒; （14）牛GPR7受体蛋白及其部分肽; （15）编码全部或部分牛GPR7的多核苷酸; （16）含有这些多核苷酸的表达载体; （17）由表达载体转化的宿主; （18）通过培养转化的宿主细胞制备牛GPR7及其部分肽; （19）抗体GPR7; （20）包含牛GPR7的药物组合物，其部分肽，编码它的多核苷酸或识别它的抗体; （21）含有牛GPR7抗体或编码全部或部分牛GPR7的多核苷酸的诊断试剂; （22）牛GPR8受体蛋白及其部分肽; （23）编码全部或部分牛GPR8的多核苷酸; 含有这些多核苷酸的表达载体; （24）由表达载体转化的宿主; （25）通过培养转化的宿主细胞制备牛GPR8及其部分肽; （26）牛GPR8抗体; （27）含有牛GPR8的药物组合物，其部分肽，编码它的多核苷酸或识别它的抗体; （28）含有牛GPR8抗体或编码全部或部分牛GPR8的多核苷酸的诊断试剂; （29）非人哺乳动物，其是含有编码（I）外源DNA，牛GPR7或牛GPR8的转基因动物，或是编码（I），牛GPR7或牛GPR8的基因的敲除动物; （30）具有（I）基因，牛GPR7或牛GPR8的非人哺乳动物胚胎干细胞（ES细胞）; （31）哺乳动物中（I）的表达载体; （32）筛选化合物能够通过在基因启动子区域控制下的报告基因转化的非人哺乳动物（I），牛GPR7或牛GPR8的基因的启动子活性的能力来筛选化合物 I），牛GPR7或牛GPR8。 活动：厌食 抑制细胞生长。 没有给出生物数据。 作用机制：改变阿片样生长抑素样受体GPR7与其配体的结合; （I）和N-末端溴化衍生物对GPR7表达具有激动作用。
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公开(公告)号：EP1237001A1
公开(公告)日：2002-09-04
申请号：EP00977973.7
申请日：2000-11-28
发明人： HINUMA, Shuji , HOSOYA, Masaki , KAWAMATA, Yuji , FUKUSUMI, Shoji
CPC分类号： G01N33/5005 , G01N33/566 , G01N33/68 , G01N33/6893 , G01N33/74 , G01N2500/00 , G01N2800/321
摘要： A method of screening a compound or a salt thereof that alters the binding property of Neuromedin U with FM-3, characterized by using Neuromedin U, a derivative thereof or a salt thereof and FM-3 or a salt thereof of the present invention, can be used for screening a therapeutic and/or prophylactic agent for hypertension or stress-related diseases. A FM-3 antagonist is useful as a therapeutic and/or prophylactic agent for hypertension or stress-related diseases.
摘要翻译： 筛选其改变Neuromedin U与FM-3的结合性质的化合物或其盐的方法，其特征在于使用本发明的神经介肽U，其衍生物或其盐和FM-3或其盐， 用于筛选高血压或应激相关疾病的治疗和/或预防剂。 FM-3拮抗剂可用作高血压或应激相关疾病的治疗和/或预防剂。
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10.发明公开NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF 审中-公开去除脱氧核糖核酸的G-PROTEIN GEKOPPELTER REZEPTORPROTEIN
公开(公告)号：EP1118621A1
公开(公告)日：2001-07-25
申请号：EP99969941.6
申请日：1999-09-30
发明人： WATANABE, Takuya , TERAO, Yasuko , FUKUSUMI, Shoji
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to a human-derived G-protein coupled receptor protein or a partial peptide thereof or a salt thereof, a nucleic acid encoding said receptor protein and a derivative thereof.
A G-protein coupled receptor protein derived from a human hippocampus according to the invention or a nucleic acid encoding said protein and a derivative thereof can be used in determining a ligand (agonist) for a G-protein coupled receptor protein of the invention, in a preventing and/or treating agent against a disease related to a dysfunction of a G-protein coupled receptor protein of the invention, in a gene diagnostic agent, and in screening for a compound capable of altering the expression level of a receptor protein of the invention or a partial peptide thereof.摘要翻译： 本发明涉及人衍生的G蛋白偶联受体蛋白或其部分肽或其盐，编码所述受体蛋白的核酸及其衍生物。 衍生自根据本发明的人海马的G蛋白偶联受体蛋白质或编码所述蛋白质及其衍生物的核酸可用于测定本发明的G蛋白偶联受体蛋白质的配体（激动剂），其在 与本发明的G蛋白偶联受体蛋白质的功能障碍相关的疾病的预防和/或治疗剂，在基因诊断剂中，以及筛选能够改变受体蛋白质的表达水平的化合物 发明或其部分肽。
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