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公开(公告)号：EP1164142A1
公开(公告)日：2001-12-19
申请号：EP00908064.9
申请日：2000-03-14
发明人： ONDA, Haruo , OGI, Kazuhiro , KITADA, Chieko , SUZUKI, Nobuhiro , OHKUBO, Shoichi , SHINTANI, Yasushi , KIKUCHI, Kuniko
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , C07K14/4702 , G01N2500/00
摘要： The present invention relates to a novel secretory protein or a partial peptide derived therefrom, or a salt thereof, a method for producing the protein, a pharmaceutical composition the protein or the like, an antibody against the protein, a method/kit for screening for a compound, or a salt thereof, promoting or inhibiting the activity of the protein, the compound obtained by such screening, and a pharmaceutical composition the compound, and the like.
The protein, partial peptide or the like of the present invention can be used as a tissue regenerating agent after excision of a diseased tissue or a diagnostic agent for cancer, and the like. The antibody of the present invention can be used in quantifying the protein of the present invention in test samples. Further, the protein of the present invention is useful as a reagent for screening for a compound promoting or inhibiting the activity of the protein of the present invention摘要翻译： 本发明涉及一种新型分泌蛋白或其衍生的部分肽或其盐，该蛋白质的制备方法，该药物组合物，该蛋白质等，针对该蛋白质的抗体，一种用于筛选该蛋白质的方法/试剂盒 化合物或其盐，促进或抑制蛋白质的活性，通过这种筛选获得的化合物和药物组合物，化合物等。 本发明的蛋白质，部分肽等可以在切除患病组织或癌症诊断剂之后作为组织再生剂使用。 本发明的抗体可用于定量测试样品中本发明的蛋白质。 此外，本发明的蛋白质可用作筛选促进或抑制本发明的蛋白质的活性的化合物的试剂
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2.发明公开NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF 审中-公开G-PROTEIN GEKOPPELTES REZEPTORPROTEIN UND DESSEN DNA
公开(公告)号：EP1207169A1
公开(公告)日：2002-05-22
申请号：EP00954968.4
申请日：2000-08-24
CPC分类号： C07K14/705 , A61K38/00 , G01N2333/726 , G01N2500/00
摘要： The present invention relates to a human-derived protein or salts thereof, a DNA encoding the protein, methods for determining a ligand to the protein, screening methods/screening kits for a compound that alters the binding property between a ligand and the protein, a compound obtainable by the screening or its salts, etc.
The human-derived protein of this invention or the DNA encoding the protein can be used for ① determination of ligands to the present invention; ② prophylactic/therapeutic agents for diseases associated with dysfunction of the protein of the present invention; ③ screening of compounds (agonists, antagonists, etc.) that alter the binding property between the protein of the present invention and ligands.摘要翻译： 本发明涉及人衍生的蛋白质或其盐，编码蛋白质的DNA，确定蛋白质配体的方法，改变配体和蛋白质之间结合性质的化合物的筛选方法/筛选试剂盒， 通过筛选获得的化合物或其盐等。本发明的人衍生蛋白质或编码该蛋白质的DNA可用于本发明的配体的1＆ 2和本发明的蛋白质功能障碍相关疾病的预防/预防/治疗剂; 3和c和筛选化合物（激动剂，拮抗剂等），其改变本发明的蛋白质和配体之间的结合性质。
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3.发明公开NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN AND DNA THEREOF 审中-公开G-PROTEIN-GEKOPPELTES REZEPTOR PROTEIN UND DESSEN DNS
公开(公告)号：EP1138693A1
公开(公告)日：2001-10-04
申请号：EP99961285.6
申请日：1999-12-09
IPC分类号： C07K14/705 , C12N15/12 , C12P21/02 , C07K16/28 , A61K39/395 , G01N33/53
CPC分类号： C07K14/723 , A01K2217/05 , A61K48/00 , C07K16/28
摘要： The G protein coupled receptor protein of the present invention, a partial peptide thereof or a salt thereof, as well as a polynucleotide encoding the same (for example, DNA, RNA and a derivative thereof), is useful in (1) determination of a ligand (agonist), (2) acquisition of an antibody and antiserum thereto, (3) construction of an expression system for a recombinant receptor protein thereof, (4) development of a binding assay system using said expression system and screening of a pharmaceutical candidate compound, (5) practice of a drug design based on comparison with structurally analogous ligand receptors, (6) reagents for preparation of probes and PCR primers in gene diagnosis, (7) preparation of a transgenic animals or (8) a pharmaceutical composition for a preventing and treating genetic agent etc.
摘要翻译： 本发明的G蛋白偶联受体蛋白质，其部分肽或其盐以及编码其的多核苷酸（例如DNA，RNA及其衍生物）可用于（1） 配体（激动剂），（2）抗体的获得和抗血清，（3）构建其重组受体蛋白质的表达系统，（4）使用所述表达系统开发结合测定系统和筛选药物候选物 化合物，（5）基于与结构类似配体受体的比较的药物设计实践，（6）用于在基因诊断中制备探针和PCR引物的试剂，（7）转基因动物的制备或（8） 预防和治疗遗传代理等
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4.发明公开NOVEL G PROTEIN-COUPLED RECEPTOR PROTEIN, ITS DNA AND LIGAND THEREOF 审中-公开灭菌剂G-PROTEIN GEKOPPELTES REZEPTORPROTEIN，DESSEN DNA UND LIGAND
公开(公告)号：EP1132405A1
公开(公告)日：2001-09-12
申请号：EP99972224.2
申请日：1999-11-11
发明人： WATANABE, Takuya , KIKUCHI, Kuniko , TERAO, Yasuko , SHINTANI, Yasushi , HINUMA, Shuji , FUKUSUMI, Shoji , FUJII, Ryo , HOSOYA, Masaki , KITADA, Chieko
IPC分类号： C07K14/705 , C12N15/12 , C12P21/02 , C07K16/28 , A61K39/395 , G01N33/50 , C07K2/00 , A61K38/00
CPC分类号： G01N33/566 , C07K14/723
摘要： The present invention relates to a novel polypeptide, its partial peptide or salt thereof, a method for manufacturing the polypeptide, a receptor of the polypeptide, a pharmaceutical composition comprising the polypeptide or the like, an antibody to the polypeptide, a method/kit for screening a compound that promotes or inhibits an activity of the polypeptide or salt thereof, a compound that can be obtained by the screening, a pharmaceutical composition comprising the compound, and the like.
The polypeptide, its partial peptide or the like of the present invention can be used, for example, as a therapeutic agent for nervous disease, a promoting agent for somatostatin secretion and the like. Further, the antibody of the present invention can be used for a quantification of the polypeptide of the present invention in a sample solution. Furthermore, the polypeptide of the present invention is useful for a reagent for screening a compound that promotes or inhibits the activity of the polypeptide of the present invention.摘要翻译： 本发明涉及新的多肽，其部分肽或其盐，制备多肽的方法，多肽的受体，包含多肽的药物组合物，多肽的抗体，多肽的抗体， 筛选促进或抑制多肽或其活性的化合物，可通过筛选获得的化合物，包含该化合物的药物组合物等。 本发明的多肽，其部分肽等可以用作神经疾病的治疗剂，生长抑素分泌促进剂等。 此外，本发明的抗体可以用于在样品溶液中定量本发明的多肽。 此外，本发明的多肽可用于筛选促进或抑制本发明多肽活性的化合物的试剂。
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