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    DERIVATIVES OF HYPOCRELLIN WITH PERI-POSITION AND 2-POSITION SIMULTANEOUSLY SUBSTITUTED BY AMINO GROUPS
    1.
    发明公开
    DERIVATIVES OF HYPOCRELLIN WITH PERI-POSITION AND 2-POSITION SIMULTANEOUSLY SUBSTITUTED BY AMINO GROUPS 审中-公开

    公开(公告)号：EP3680230A1

    公开(公告)日：2020-07-15

    申请号：EP18854509.9

    申请日：2018-09-05

    申请人： Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences

    发明人： WANG, Pengfei ,  WU, Jiasheng ,  LIU, Weimin ,  ZHENG, Xiuli ,  GU, Ying

    IPC分类号： C07C221/00 ,  C07C225/32 ,  C07C249/02 ,  C07C251/24 ,  A61K41/00 ,  A61P35/00

    摘要： The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d:

    The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M -1 cm -1 . Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

    PREPARATION METHOD OF HETEROATOM DOPED MULTIFUNCTIONAL CARBON QUANTUM DOT AND APPLICATION THEREOF
    4.
    发明公开
    PREPARATION METHOD OF HETEROATOM DOPED MULTIFUNCTIONAL CARBON QUANTUM DOT AND APPLICATION THEREOF 审中-公开
    用于生产杂原子掺杂的多功能量子点和它们的用途

    公开(公告)号：EP2883835A1

    公开(公告)日：2015-06-17

    申请号：EP13828194.4

    申请日：2013-03-06

    申请人： Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences

    发明人： WANG, Pengfei ,  GE, Jiechao ,  LAN, Minhuan ,  LIU, Weimin

    IPC分类号： C01B31/02

    摘要： The present invention discloses a method for preparing heteroatom doped carbon quantum dot, and application thereof in fields of biomedicine, catalysts, photoelectric devices, etc. The various kinds of heteroatom doped carbon quantum dots are obtained by using a conjugated polymer as a precursor and through a process of high temperature carbonization. These carbon quantum dots contain one or more heteroatoms selected from the group consisting of N, S, Si, Se, P, As, Ge, Gd, B, Sb and Te, the absorption spectrum of which ranges from 300 to 850 nm, and the fluorescence emission wavelength of which is within a range of 350 to 1000 nm. The carbon quantum dot has a broad application prospect in serving as a new type photosensitizer, preparing drugs for photodynamic therapy of cancer and sterilization, photocatalytic degradation of organic pollutants, photocatalytic water-splitting for hydrogen generation, organic polymer solar cell and quantum dot-sensitized solar cell.