摘要:
The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
摘要:
The present invention relates to novel N-[2-(2-pyridinyl)cyclopropyl]benzamide derivatives (I), their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
摘要:
The present invention relates to a palladium-arsenic catalytic process for the preparation of amides capable of advantageously converting a nitrile into the respective amide under mild reaction conditions, such as a neutral pH and low temperatures.
摘要:
The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one such compound.
摘要:
This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要:
A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.
摘要翻译:制备式II或式I的取代的脲化合物或其药学上可接受的盐或其酯,式II,式I的方法包括式II'或式1'的中间体,式II', 式I'与具有式R 1 R 2 NC(= O)Hal的氨基甲酰卤在基本上由吡啶组成的溶剂中,其中Hal表示Cl,F,I或Br,其中环A和R1,R2,R5,V ,W,X,Y和Z如本文所定义。
摘要:
This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要:
Disclosed are compounds of formula (V), wherein R2 and R7, independently of each other, are H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl or halogen; R3 and R6, independently of each other, are H, C1-C4 alkyl, C7-C12 aralkyl or C6-C16 aryl; R4 is H, C1-C20 alkyl, C5-C8 cycloalkyl, C6-C12 aryl or C7-C12 aralkyl, the alkyl, cycloalkyl, aralkyl and aryl radicals being unsubstituted or substituted with C1-C4 alkoxy, F, Cl, Br, -CN, C1-C4 alkyl or -NO2; Me is a lanthanide metal or yttrium; Y is an anion of an acid; n stands for 2 or 3 and m is 1, 2 or 3; R9 is a radical of formula (VI) -Xp-A-X'q-A'r-Oligo, and R8 is H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl, or R9 is H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl and R8 is a radical of formula (VI); p, q and r, independently of one another, are 0 or 1; X and X', independently of each other, are a radical unsubstituted or substituted by C1-C4 alkoxy, F, Cl, Br, -CN, C1-C4 alkyl or -NO2 substituted radical selected from the group consisting of C1-C20 alkylene, C2-C12 alkenylene, C2-C12 alkinylene, -(CxH2xO)y-, wherein x equals a number from 2 to 6 and y equals a number from 1 to 20, C5-C8 cycloalkylene, C6-C12 arylene and C7-C12 aralkylene; A and A', independently of each other, are -O-, -S-, -S-S-, -NR12-CO-NR12-CO-NR12-, -NR12-CS-NR12-, -NR12-, -NR12-C(O)-O-, -C(O)O-, -C(O)S-, -C(O)NR12-, -C(S)S-, -C(S)O-, -C(S)NR12-, -SO2NR12-, -SO2-, -P(O)(OH)O-, P(S)(SH)S-, -P(S)(SH)O-, -P(S)(OH)O-, -P(O)(SH)S-, -P(O)(OH)S-, -P(O)(SH)O-, -P(O)(OH)-NR12-, -P(S)(SH)-NR12-, -P(S)(OH)-NR12-, -P(O)(SH)-NR12-, -HP(O)O-, -HP(S)S-, -HP(O)NR12- or -HP(S)NR12-, R12 being H or C1-C6 alkyl; and oligo is a natural, modified or synthetic sequence of natural, modified or synthetic deoxynucleosides or peptide nucleic acid units which are bonded via a nucleic base, an internucleotide bridge or a sugar and whose inner region is complementary to a target RNA.