利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.028 秒)

    RECOMBINANT ANTI-CD64-ETA' IMMUNOTOXINS
    6.
    发明授权
    RECOMBINANT ANTI-CD64-ETA' IMMUNOTOXINS 有权
    重组抗CD64-ETA“免疫毒素

    公开(公告)号：EP1694709B1

    公开(公告)日：2010-12-15

    申请号：EP04819218.1

    申请日：2004-11-25

    申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

    发明人： HUHN, Michael ,  FISCHER, Rainer ,  TUR, Mehmet Kemal ,  THEPEN, Theo ,  BARTH, Stefan

    IPC分类号： C07K19/00 ,  A61P35/00 ,  C07K14/195

    CPC分类号： C07K16/283 ,  A61K38/164 ,  A61K38/168 ,  A61K47/6829 ,  A61K47/6849 ,  C07K2317/622 ,  A61K2300/00

    摘要： The present invention relates to a heterologous, recombinantly prepared complex which comprises at least one cytotoxic domain and at least one CD64-specific binding domain, especially of human origin, and nucleic acids and vectors coding for such a complex. It further relates to methods for influencing cell growth and the physiology of CD64-positive cells with the complex according to the invention or with vectors containing the nucleic acid coding therefore. The invention further relates to vectors and hosts for producing the complex according to the invention. It further relates to the preparation and distribution of medicaments based on the complex according to the invention or vectors coding therefore, for the treatment of diseases based on a pathological proliferation and/or increased activity of structurally defined cell populations. This applies, in particular, to tumour diseases, allergies, autoimmune diseases, infectious diseases, chronic inflammation or transplantations (immune suppression).

    TARGETED MODULATION OF MACROPHAGES
    9.
    发明公开
    TARGETED MODULATION OF MACROPHAGES 有权
    GEZIELTE MODULATION VON MAKROPHAGEN

    公开(公告)号：EP3003350A1

    公开(公告)日：2016-04-13

    申请号：EP14728872.4

    申请日：2014-05-27

    申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Rheinisch-Westfälische Technische Hochschule Aachen

    发明人： THEPEN, Theophilus ,  HRISTODOROV, Dimitrij ,  MLADENOV, Radoslav ,  BARTH, Stefan

    IPC分类号： A61K38/17 ,  A61K47/48 ,  C12N15/113

    CPC分类号： C07K14/4705 ,  A61K38/177 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  Y02A50/473

    摘要： An immunomodulatory fusion protein (IFP) for converting pro-inflammatory M macrophages to anti-inflammatory M2 like phenotypes of macrophagesthe IFP having at least one component A and at least one component B wherein the component A is comprising or consisting of a binding domain for extra-cellular surface structures of a macrophage that internalizes said immunomodulatory fusion protein upon binding of component A of said immunomodulatory fusion protein, and the component B is modulating the macrophage and comprises or consists of a DNA oligonucleotide or RNA oligonucleotide or a chemical small molecule exhibiting modulatory functions to targeted macrophages or a polypeptide which amino acid sequence comprises or consists of a macrophage modulatory protein or comprises or consists of at least a partial sequence of the macrophage modulatory protein, the partial sequence having maintained the modulatory function of the macrophage modulatory protein.

    摘要翻译： 用于将促炎症M巨噬细胞转化为抗巨噬细胞M2型表型的免疫调节融合蛋白（IFP），具有至少一种组分A和至少一种组分B的IFP，其中组分A包含或由结合域组成， 当所述免疫调节融合蛋白的组分A结合时使所述免疫调节融合蛋白内在化的巨噬细胞的细胞表面结构和组分B调节巨噬细胞，并且包含或由DNA寡核苷酸或RNA寡核苷酸或显示调节的化学小分子 靶向巨噬细胞或多肽，其氨基酸序列包含巨噬细胞调节蛋白或由巨噬细胞调节蛋白组成，或由至少部分巨噬细胞调节蛋白的部分序列组成，部分序列维持巨噬细胞调节蛋白的调节功能。