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公开(公告)号：EP3277822B1
公开(公告)日：2020-05-06
申请号：EP16773586.9
申请日：2016-03-31
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John
IPC分类号： C12N15/81
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公开(公告)号：EP3411485A1
公开(公告)日：2018-12-12
申请号：EP17747883.1
申请日：2017-02-02
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John , YAP, Sihui Amy
IPC分类号： C12N15/80 , C12N15/113
摘要： The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil- accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
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公开(公告)号：EP3277822A1
公开(公告)日：2018-02-07
申请号：EP16773586.9
申请日：2016-03-31
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John
IPC分类号： C12N15/81
CPC分类号： C12N15/815 , C12N1/16 , C12N15/80 , C12N15/81 , C12N2830/36 , C12N2840/002
摘要： The present invention relates to the field of fungal biotechnology, more particularly to a strong inducible gene expression system in fungal species, such as a species of the Rhodosporidium genus or the Rhodotorula genus.
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公开(公告)号：EP3234105B1
公开(公告)日：2020-04-15
申请号：EP15870471.8
申请日：2015-12-14
发明人： LIU, Yanbin , KOH, Chong Mei , JI, Lianghui
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公开(公告)号：EP3191577B1
公开(公告)日：2019-04-17
申请号：EP15840158.8
申请日：2015-08-21
发明人： LIU, Yanbin , KOH, Chong Mei , JI, Lianghui
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公开(公告)号：EP3580325A1
公开(公告)日：2019-12-18
申请号：EP18750679.5
申请日：2018-01-29
发明人： JI, Lianghui , LIU, Yanbin , KOH, Chong Mei John , YAP, Sihui Amy , NGOH, Si Te
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7.发明公开METHODS FOR TUNING CAROTENOID PRODUCTION LEVELS AND COMPOSITIONS IN RHODOSPORIDIUM AND RHODOTORULA GENERA 审中-公开方法调整类胡萝卜素和Rhodotorulra genra的类胡萝卜素生产水平和组成
公开(公告)号：EP3234105A1
公开(公告)日：2017-10-25
申请号：EP15870471.8
申请日：2015-12-14
发明人： LIU, Yanbin , KOH, Chong Mei , JI, Lianghui
CPC分类号： C07K14/37 , C12N9/0008 , C12N15/113 , C12N15/80 , C12P21/02 , C12P23/00
摘要： The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of carotenoids in fungal hosts selected from Rhodospordium and Rhodotorula genera.
摘要翻译： 本发明涉及真菌生物技术领域，更具体地涉及用于在选自Rhodospordium和Rhodotorula属的真菌宿主中生产类胡萝卜素的基因工程方法。
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8.发明公开METHODS FOR EFFICIENT PRODUCTION OF POLYUNSATURATED FATTY ACIDS (PUFA) IN RHODOSPORIDIUM AND RHODOTORULA SPECIES 审中-公开有效生产多种不饱和脂肪酸（多不饱和脂肪酸）的方法
公开(公告)号：EP3191577A1
公开(公告)日：2017-07-19
申请号：EP15840158.8
申请日：2015-08-21
发明人： LIU, Yanbin , KOH, Chong Mei , JI, Lianghui
CPC分类号： C12P7/6427 , C12N9/0006 , C12N9/0008 , C12N9/0071 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12N15/81 , C12P7/6463 , C12Y101/0104 , C12Y102/01003 , C12Y102/01012 , C12Y114/19 , C12Y114/19001 , C12Y114/19003 , C12Y114/19006 , C12Y203/0102 , C12Y203/03008 , C12Y401/01001 , C12Y402/01011 , C12Y502/01008 , C12Y602/01003 , C12Y604/01002
摘要： The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions.
摘要翻译： 本发明涉及真菌生物技术领域，更具体地涉及在选自红冬孢酵母属（Rhodosporidium）和红酵母属（Rhodotorula）属的真菌宿主中生产多不饱和脂肪酸（PUFA）的基因工程方法。 本发明进一步涉及具有降低的天然醛脱氢酶（ALD1）酶活性的修饰的真菌宿主细胞，以及通过在合适的条件下培养所述真菌宿主细胞来生产ω-3和ω-6脂肪酸和三酰甘油酯的方法。
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