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公开(公告)号：EP1318809A1
公开(公告)日：2003-06-18
申请号：EP01965915.0
申请日：2001-08-14
发明人： KORDOVA, Marco , SCHWARTZ, Anchel , DOLITZKY, Ben-Zion , ARONHIME, Judith , LEONOV, David , ZAVUROV, Shlomo , SALYI, Szabolcs , MESZAROS-SOS, Erzsebet
IPC分类号： A61K31/44
CPC分类号： C07D213/74 , A61K9/14 , A61K31/44
摘要： The present invention relates to torsemide having relatively small particles, and corresponding relatively large surface area. In one embodiment, the invention relates to torsemide and formulations containing torsemide having a mean particle diameter of less than 200 micrometers.
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2.发明授权SELECTIVE ENZYMATIC ESTERIFICATION AND SOLVOLYSIS OF EPIMERIC VITAMIN D ANALOG AND SEPARATION OF THE EPIMERS 有权酶促选择性酯化和溶剂分解差向异构体维生素D类似物和差向异构体分离
公开(公告)号：EP1470220B1
公开(公告)日：2011-10-05
申请号：EP03729607.6
申请日：2003-01-09
IPC分类号： C12P41/00
CPC分类号： C12P7/18 , C12P41/004
摘要： Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The method can be used, for example, for separating mixed epimers of the vitamin D analog.
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3.发明公开SELECTIVE ENZYMATIC ESTERIFICATION AND SOLVOLYSIS OF EPIMERIC VITAMIN D ANALOG AND SEPARATION OF THE EPIMERS 有权酶促选择性酯化和溶剂分解差向异构体维生素D类似物和差向异构体分离
公开(公告)号：EP1470220A2
公开(公告)日：2004-10-27
申请号：EP03729607.6
申请日：2003-01-09
IPC分类号： C12N9/20
CPC分类号： C12P7/18 , C12P41/004
摘要： Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The method can be used, for example, for separating mixed epimers of the vitamin D analog.
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公开(公告)号：EP1207880A1
公开(公告)日：2002-05-29
申请号：EP00957398.1
申请日：2000-08-11
IPC分类号： A61K31/44 , A61K31/4406 , A61K31/4409 , C07D213/71 , C07D213/74
CPC分类号： C07D213/74 , A61K31/64
摘要： The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol adduct. Methods for their preparation are also disclosed. The present invention also relates to processes for making torsemide modification (I). Pharmaceutical compositions containing the new forms of torsemide and methods of using them are also disclosed.
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公开(公告)号：EP1922303A2
公开(公告)日：2008-05-21
申请号：EP06800112.2
申请日：2006-07-18
发明人： SCHWARTZ, Anchel , PLOUTNO, Alexei , WOLFMAN, Koby
IPC分类号： C07C401/00 , A61K31/59 , A61P5/20
CPC分类号： C07C401/00
摘要： The present invention is directed to a novel process for preparing Paricalcitol wherein Paricalcitol, dissolved in a solvent, is precipitated from a concentrated or seeded solution.
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公开(公告)号：EP1685099A1
公开(公告)日：2006-08-02
申请号：EP05810281.5
申请日：2005-07-01
IPC分类号： C07C401/00 , A61K31/592
CPC分类号： C07C401/00
摘要： Provided are novel crystalline forms of 1,24-(S)-dihydroxy vitamin D2, including hydrates and solvates, and methods for making them. Also provided are pharmaceutical and nutraceutical compositions containing the novel crystalline forms.
摘要翻译： 提供了1,24-（S） - 二羟基维生素D 2的新型结晶形式，包括水合物和溶剂化物，以及制备它们的方法。 还提供了含有新颖结晶形式的药物和营养组合物。
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