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1.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T-ZELLEN-BALANCE-GENEXPRESSSION，MATERIALZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP3110971A2
公开(公告)日：2017-01-04
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/68
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
摘要翻译： 本发明一般涉及用于鉴定调节，控制或以其它方式影响T细胞平衡的调节网络的组合物和方法，例如Th17细胞分化，维持和/或功能，以及用于利用调节网络的组合物和方法， 控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡。 本发明还涉及鉴定和利用调节，控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡的靶基因和/或靶基因产物。
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公开(公告)号：EP3377086A1
公开(公告)日：2018-09-26
申请号：EP16816778.1
申请日：2016-11-17
申请人： The Brigham and Women's Hospital, Inc. , The Broad Institute Inc. , Massachusetts Institute Of Technology
发明人： KUCHROO, Vijay K. , WANG, Chao , REGEV, Aviv , SHEKHAR, Karthik
CPC分类号： C07K14/70596 , A61K38/1709 , A61K38/177 , A61K38/208 , A61K39/3955 , A61K45/06 , A61K2039/575 , A61P1/00 , A61P35/00 , A61P37/00 , C07K14/5434 , C07K16/244 , C07K16/2896 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/20
摘要： Described herein are methods for suppressing an immune response in a subject, e.g., a subject with an autoimmune disease, by administering to the subject a therapeutically effective amount of recombinant CD5L, CD5L homodimers and/or CD5L:p40 heterodimers, or nucleic acids encoding any of these. Also described are methods for enhancing an immune response in a subject, e.g., a subject with cancer, infection, or an immune deficiency, by administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds specifically to CD5L, D5L homodimers and/or CD5L:p40 heterodimers, and inhibits their binding to the IL-23 receptor, or inhibits formation of the CD5L homodimer and/or CD5L:p40 heterodimer, or inhibitory nucleic acids that target CD5L and/or p40.
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3.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T细胞平衡基因表达，物质组合物及其使用方法
公开(公告)号：EP3262193A2
公开(公告)日：2018-01-03
申请号：EP16714607.5
申请日：2016-02-26
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , The Regents of the University of California
发明人： REGEV, Aviv , KUCHROO, Vijay, K. , GAUBLOMME, Jellert , LEE, Youjin , WANG, Chao , YOSEF, Nir , PARK, Hongkun , KAMINSKI, James
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G01N33/5023
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP3634465A1
公开(公告)日：2020-04-15
申请号：EP18806944.7
申请日：2018-05-25
申请人： The Broad Institute, Inc. , The Brigham And Women's Hospital, Inc. , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay, K. , WANG, Chao , REGEV, Aviv
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公开(公告)号：EP3110971B1
公开(公告)日：2019-05-08
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/6883 , C07K16/28 , G01N33/68
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公开(公告)号：EP3630156A1
公开(公告)日：2020-04-08
申请号：EP18806188.1
申请日：2018-05-25
申请人： The Broad Institute, Inc. , The Brigham and Women's Hospital, Inc. , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay, K. , WANG, Chao , REGEV, Aviv
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7.发明公开
公开(公告)号：EP3368689A2
公开(公告)日：2018-09-05
申请号：EP16795490.8
申请日：2016-10-28
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Regev, Aviv , Anderson, Ana C. , Cong, Le , Kuchroo, Vijay K. , Singer, Meromit , Wang, Chao
发明人： REGEV, Aviv , ANDERSON, Ana, Carrizosa , CONG, Le , KUCHROO, Vijay, K. , SINGER, Meromit , WANG, Chao
IPC分类号： C12Q1/68 , C12N5/0783
CPC分类号： C12Q1/6886 , C12N5/0636 , C12N2510/00 , C12Q1/6881 , C12Q2600/158
摘要： The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.
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公开(公告)号：EP3942023A1
公开(公告)日：2022-01-26
申请号：EP20720562.6
申请日：2020-03-18
申请人： The Broad Institute, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The Brigham & Women's Hospital, Inc. , The Regents of the University of California
发明人： REGEV, Aviv , WANG, Chao , KUCHROO, Vijay K. , YOSEF, Nir , WAGNER, Allon , FESSLER, Johannes
IPC分类号： C12N5/0783 , C12N9/10 , C12N9/02 , A61K31/132 , C12N9/88
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公开(公告)号：EP4222374A1
公开(公告)日：2023-08-09
申请号：EP21876560.0
申请日：2021-10-01
发明人： WANG, Chao , GE, Zhifei , LI, Ju
IPC分类号： F03G7/00
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