专利检索 ap:("The California Institute for Biomedical Research" OR "The Scripps Research Institute") AND inv:"ZOU, Huafei" 第 1 页

1.

发明公开
MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND COMPOSITIONS THEREOF 审中-公开
标题翻译：改良治疗药物，通用药物佐剂

公开(公告)号：EP3082797A1

公开(公告)日：2016-10-26

申请号：EP14872951.0

申请日：2014-12-17

申请人： The California Institute for Biomedical Research , The Scripps Research Institute

发明人： SHEN, Weijun , YANG, Pengyu , ZOU, Huafei , SCHULTZ, Peter G.

IPC分类号： A61K31/23 , A61K31/20 , A61K47/48 , A61K47/30

CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0021 , A61K9/703 , A61K38/2278 , A61K38/26 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/554 , A61K47/60

摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

摘要翻译： 提供了用于延长治疗剂的半衰期的方法和组合物。改性治疗剂（mTA）包含治疗剂，短纤维和半衰期延长分子。本文公开的mTA可用于治疗有需要的受试者的疾病或病症。

2.

发明公开
OXYNTOMODULIN ANALOGS AND METHODS OF MAKING AND USING SAME 审中-公开

公开(公告)号：EP3368693A2

公开(公告)日：2018-09-05

申请号：EP16861037.6

申请日：2016-10-31

申请人： The Research Foundation For The State University Of New York University at Buffalo , The California Institute for Biomedical Research

发明人： LIN, Qing , MUPPIDI, Avinash , SHEN, Weijun , ZOU, Huafei , SCHULTZ, Peter , TIAN, Yulin

IPC分类号： C12Q1/68

CPC分类号： A61K38/26 , A61K38/00 , C07K14/575 , C07K14/605 , C12Q1/6883

摘要： Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.

3.

发明公开
MODIFIED THERAPEUTIC AGENTS, STAPLED PEPTIDE LIPID CONJUGATES, AND COMPOSITIONS THEREOF 审中-公开

公开(公告)号：EP4212180A1

公开(公告)日：2023-07-19

申请号：EP22205613.7

申请日：2014-12-17

申请人： The Scripps Research Institute

发明人： SHEN, Weijun , YANG, Pengyu , ZOU, Huafei , SCHULTZ, Peter G.

IPC分类号： A61K47/54 , A61K47/30 , A61K38/16 , A61P25/00 , A61P29/00 , A61K47/60 , A61K38/26 , A61K38/22 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/10 , A61P17/06 , A61P25/14 , A61P25/16 , A61P43/00 , A61K9/00

摘要： Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.