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公开(公告)号：EP3254008B1
公开(公告)日：2018-12-26
申请号：EP16708248.6
申请日：2016-02-04
IPC分类号： F16K99/00
CPC分类号： B01L3/502738 , B01L2200/027 , B01L2300/0816 , B01L2300/12 , B01L2300/123 , B01L2300/14 , B01L2400/0638 , B01L2400/082 , C12M21/08 , C12M23/16 , F16K7/126 , F16K99/0015 , F16K2099/008
摘要： Systems and methods disclosed herein related to an apparatus including a fluid flow plate and a microfluidic valve assembly. The fluid flow plate includes a plurality of polymer layers that define a fluid flow passage through the microfluidic valve assembly. The microfluidic valve assembly includes a valve seat, a flexible membrane, a valve cavity, a valve head, and an actuator. The actuator is configured to selectively control pressure applied by the valve head to the flexible membrane, such that in a first actuator state the valve head depresses the flexible membrane into the valve cavity and into contact with the valve seat, thereby preventing fluid flow through the valve assembly, and in a second state, the valve head and the flexible membrane are retracted substantially out of the valve cavity allowing fluid to flow through the valve assembly. In various implementations, the valve seat and/or the flexible membrane include an elastomer layer.
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公开(公告)号：EP3545074A1
公开(公告)日：2019-10-02
申请号：EP17817960.2
申请日：2017-11-21
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公开(公告)号：EP2951282B1
公开(公告)日：2019-05-08
申请号：EP14706712.8
申请日：2014-01-29
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公开(公告)号：EP3254008A1
公开(公告)日：2017-12-13
申请号：EP16708248.6
申请日：2016-02-04
IPC分类号： F16K99/00
CPC分类号： B01L3/502738 , B01L2200/027 , B01L2300/0816 , B01L2300/12 , B01L2300/123 , B01L2300/14 , B01L2400/0638 , B01L2400/082 , C12M21/08 , C12M23/16 , F16K7/126 , F16K99/0015 , F16K2099/008
摘要： Systems and methods disclosed herein related to an apparatus including a fluid flow plate and a microfluidic valve assembly. The fluid flow plate includes a plurality of polymer layers that define a fluid flow passage through the microfluidic valve assembly. The microfluidic valve assembly includes a valve seat, a flexible membrane, a valve cavity, a valve head, and an actuator. The actuator is configured to selectively control pressure applied by the valve head to the flexible membrane, such that in a first actuator state the valve head depresses the flexible membrane into the valve cavity and into contact with the valve seat, thereby preventing fluid flow through the valve assembly, and in a second state, the valve head and the flexible membrane are retracted substantially out of the valve cavity allowing fluid to flow through the valve assembly. In various implementations, the valve seat and/or the flexible membrane include an elastomer layer.
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公开(公告)号：EP2951282A1
公开(公告)日：2015-12-09
申请号：EP14706712.8
申请日：2014-01-29
发明人： CUIFFI, Joseph Dennis , MESCHER, Mark Joseph , COPPETA, Jonathan Robert , INMAN, Samuel Walker , SPENCER, Abigail June , NGUYEN, Transon Van , BORENSTEIN, Jeffrey T.
CPC分类号： C12M21/08 , C12M23/12 , C12M23/44 , C12M29/00 , C12M29/04 , C12M29/12 , C12M35/08 , C12M41/00 , C12M41/12 , C12N5/0062 , C12N5/0602 , C12N5/0697
摘要： The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.
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