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公开(公告)号：EP3411391A1
公开(公告)日：2018-12-12
申请号：EP17746656.2
申请日：2017-01-31
发明人： DUROCHER, Daniel , SIDHU, Sachdev , ZHANG, Wei , SICHERI, Frank , CANNY, Marella
摘要： 53BP1 inhibitors, derived from the modification of wild-type ubiquitin, as well as compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
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公开(公告)号：EP3033356A1
公开(公告)日：2016-06-22
申请号：EP14755545.2
申请日：2014-08-14
发明人： GAKHAL, Amandeep , SIDHU, Sachdev , PAN, Guohua , MOFFAT, Jason , ROBITAILLE, Melanie , ANGERS, Stephane
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
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3.发明公开SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME 审中-公开酶或基板的活性中心的特异性抑制剂结合配偶及其制造方法
公开(公告)号：EP2603519A2
公开(公告)日：2013-06-19
申请号：EP11749910.3
申请日：2011-06-08
发明人： SIDHU, Sachdev , BEATTY, Linda , ERNST, Andreas
IPC分类号： C07K14/47
CPC分类号： C07K14/435 , A61K38/17 , C07K14/47
摘要： The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
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公开(公告)号：EP3529279A1
公开(公告)日：2019-08-28
申请号：EP17863201.4
申请日：2017-10-19
发明人： MOFFAT, Jason , ADAMS, Jarrett , PAN, Guohua , SIDHU, Sachdev , WILLIAMS, Rashida , ZHANG, Xiaoyu , SINGH, Sheila , VENUGOPAL, Chitra , VORA, Parvez
IPC分类号： C07K16/28 , A61K35/17 , A61K39/395 , A61K47/68 , A61P35/00 , C07K14/705 , C07K16/30 , C07K16/46 , C07K19/00 , C12N5/10
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5.发明公开
公开(公告)号：EP3366697A1
公开(公告)日：2018-08-29
申请号：EP17209579.6
申请日：2011-06-08
发明人： SIDHU, Sachdev , BEATTY, Linda , ERNST, Andreas
IPC分类号： C07K14/435
CPC分类号： C07K14/435 , A61K38/17 , C07K14/47
摘要： The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
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公开(公告)号：EP3585814A1
公开(公告)日：2020-01-01
申请号：EP18757454.6
申请日：2018-02-22
发明人： SIDHU, Sachdev , MIERSCH, Shane , GEYER, Clarence
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公开(公告)号：EP2761064A2
公开(公告)日：2014-08-06
申请号：EP12853399.9
申请日：2012-09-27
发明人： SIDHU, Sachdev , MOFFAT, Jason , PERSSON, Helena , PATEL, Nish , SUNDARARAJAN, Saravanan , GAKHAL, Amandeep , YE, Wei , TOMIC, Jelena ,
CPC分类号： G01N33/6854 , C12N15/1037 , G01N33/6857
摘要： There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.
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