公开(公告)号：EP3004357A1

公开(公告)日：2016-04-13

申请号：EP14808337.1

申请日：2014-06-04

申请人： The Johns Hopkins University ,  Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  MENEZES, Mitchell, E. ,  SARKAR, Devanand ,  POMPER, Marting, G.

IPC分类号： C12N15/64

CPC分类号： C12N15/85 ,  A61K38/164 ,  A61K38/1703 ,  A61K38/20 ,  A61K41/0028 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  A61K49/00 ,  A61N7/00 ,  A61N2007/0039 ,  B82Y5/00 ,  B82Y15/00 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/54 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/035 ,  C12N7/00 ,  C12N15/625 ,  C12N15/64 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2799/02 ,  C12N2799/022 ,  C12N2800/22 ,  C12N2810/855 ,  C12N2830/002 ,  C12N2830/008 ,  G01N33/50 ,  G01N33/574

摘要： The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

摘要翻译： 目前公开的主题涉及涉及可以同时进行癌症特异性病毒复制，诊断基因产物表达和治疗性基因表达的癌症核糖核酸构建体的组合物和方法。

公开(公告)号：EP3003393A2

公开(公告)日：2016-04-13

申请号：EP14808444.5

申请日：2014-06-04

申请人： The Johns Hopkins University ,  Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  MENEZES, Mitchell E. ,  SARKAR, Devanand ,  POMPER, Martin, G.

IPC分类号： A61K48/00

CPC分类号： A61K48/0058 ,  A61K9/0019 ,  A61K38/20 ,  A61K41/0028 ,  A61K41/0033 ,  A61K49/0013 ,  A61K49/0045 ,  A61K49/0054 ,  A61K51/00 ,  A61K51/0491 ,  C12N7/00 ,  C12N15/86 ,  C12N15/87 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2710/16143 ,  C12N2710/16171 ,  C12N2830/008 ,  C12Q1/6897

摘要： The presently disclosed subject matter relates to compositions and methods directed to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

摘要翻译： 目前公开的主题通常涉及它们用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。 特别地，本公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

公开(公告)号：EP3003022B1

公开(公告)日：2017-11-22

申请号：EP14817622.5

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  DASH, Rupesh ,  SARKAR, Devanand ,  SARKAR, Siddik ,  WINDLE, Jolene

IPC分类号： A01K67/027 ,  A61K48/00 ,  C12N15/86

CPC分类号： A61K48/0058 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0393 ,  A61K35/761 ,  A61K49/0008 ,  A61K49/005 ,  C12N15/86 ,  C12N2015/8536 ,  C12N2015/8572 ,  C12N2710/10332 ,  C12N2830/008 ,  C12N2830/34

摘要： Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.

公开(公告)号：EP3003022A1

公开(公告)日：2016-04-13

申请号：EP14817622.5

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  DASH, Rupesh ,  SARKAR, Devanand ,  SARKAR, Siddik ,  WINDLE, Jolene

IPC分类号： A01K67/027

CPC分类号： A61K48/0058 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0393 ,  A61K35/761 ,  A61K49/0008 ,  A61K49/005 ,  C12N15/86 ,  C12N2015/8536 ,  C12N2015/8572 ,  C12N2710/10332 ,  C12N2830/008 ,  C12N2830/34

摘要： Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.

摘要翻译： 提供了其中一种或多种元件（例如病毒复制所需的基因，可检测的显像剂，治疗剂等）的表达由截短的CCN1癌症选择性启动子（tCCN1-Prom）驱动的重组载体，细胞和 含有这种载体的转基因动物。 载体用于癌症治疗和/或诊断，转基因小鼠用于监测癌症进展，例如， 在筛选测定中。

公开(公告)号：EP3004872B1

公开(公告)日：2017-10-18

申请号：EP14807809.0

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  MENEZES, Mitchell, D. ,  SARKAR, Devanand

IPC分类号： G01N33/48 ,  C07K14/00 ,  C12N15/86 ,  A61K49/00 ,  G01N33/574

CPC分类号： C12N15/86 ,  A61K49/0008 ,  C07K14/47 ,  C12N15/85 ,  C12N15/8509 ,  C12N2710/10331 ,  C12N2710/10345 ,  C12N2830/008 ,  C12N2830/85 ,  G01N33/5088 ,  G01N33/57492

公开(公告)号：EP3004153A1

公开(公告)日：2016-04-13

申请号：EP14807031.1

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  BHOOPATHI, Praveen ,  DAS, Swadesh, K. ,  EMDAD, Luni ,  SARKAR, Devanand ,  SOKHI, Upneet

IPC分类号： C07K14/52

摘要： Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.

公开(公告)号：EP3743094A2

公开(公告)日：2020-12-02

申请号：EP19743329.5

申请日：2019-01-23

申请人： Virginia Commonwealth University ,  Fisher, Paul ,  Menezes, Mitchell, E. ,  Bhoopathi, Praveen ,  Das, Swadesh K. ,  Emdad, Luni ,  Sarkar, Devanand ,  Pradhan, Anjan, K. ,  Wang, Xiang-Yang

发明人： FISHER, Paul, B. ,  MENEZES, Mitchell, E. ,  BHOOPATHI, Praveen ,  DAS, Swadesh, K. ,  EMDAD, Luni ,  SARKAR, Devanand ,  PRADHAN, Anjan, K. ,  WANG, Xiang-yang

IPC分类号： A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30

公开(公告)号：EP3004153B1

公开(公告)日：2019-10-30

申请号：EP14807031.1

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  BHOOPATHI, Praveen ,  DAS, Swadesh, K. ,  EMDAD, Luni ,  SARKAR, Devanand ,  SOKHI, Upneet

IPC分类号： C07K14/54 ,  C12N15/62 ,  C12N15/24 ,  A61K38/20

公开(公告)号：EP3004872A1

公开(公告)日：2016-04-13

申请号：EP14807809.0

申请日：2014-06-04

申请人： Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  MENEZES, Michelle, D. ,  SARKAR, Devanand

IPC分类号： G01N33/48

CPC分类号： C12N15/86 ,  A61K49/0008 ,  C07K14/47 ,  C12N15/85 ,  C12N15/8509 ,  C12N2710/10331 ,  C12N2710/10345 ,  C12N2830/008 ,  C12N2830/85 ,  G01N33/5088 ,  G01N33/57492

摘要： Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin (
mda -9) cancer selective promoter are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, especially to visualize (image) and treat metastasis (including in rapid in vitro assays), and the transgenic mice are used to monitor cancer progression and/or the efficacy of candidate therapeutic agents in screening assays.