公开(公告)号：EP3003393A2

公开(公告)日：2016-04-13

申请号：EP14808444.5

申请日：2014-06-04

申请人： The Johns Hopkins University ,  Virginia Commonwealth University

发明人： FISHER, Paul, B. ,  DAS, Swadesh, K. ,  MENEZES, Mitchell E. ,  SARKAR, Devanand ,  POMPER, Martin, G.

IPC分类号： A61K48/00

CPC分类号： A61K48/0058 ,  A61K9/0019 ,  A61K38/20 ,  A61K41/0028 ,  A61K41/0033 ,  A61K49/0013 ,  A61K49/0045 ,  A61K49/0054 ,  A61K51/00 ,  A61K51/0491 ,  C12N7/00 ,  C12N15/86 ,  C12N15/87 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2710/16143 ,  C12N2710/16171 ,  C12N2830/008 ,  C12Q1/6897

摘要： The presently disclosed subject matter relates to compositions and methods directed to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

摘要翻译： 目前公开的主题通常涉及它们用于癌症成像，癌症治疗和组合成像和治疗方案中的遗传构建体和方法。 特别地，本公开的主题涉及允许同时进行癌症特异性病毒复制，诊断基因产物的表达和治疗基因表达的三方式癌症核糖核酸构建体。

公开(公告)号：EP3389696A1

公开(公告)日：2018-10-24

申请号：EP16876761.4

申请日：2016-12-16

申请人： The Johns Hopkins University

发明人： LEE, Seulki ,  POMPER, Martin, G. ,  PARK, Jong-Sung ,  OH, Yumin ,  SCULLY, Magdalena ,  HORTON, Maureen

IPC分类号： A61K38/19 ,  A61K39/395 ,  A61P17/00 ,  A61P37/00

CPC分类号： C07K16/2878 ,  A61K38/177 ,  A61K39/39541 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/75 ,  A61K2300/00

摘要： The present disclosure relates to methods and compositions for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc; scleroderma). The method includes administering to a subject in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), agonistic death receptor antibodies, and variants, analogues, or derivatives thereof. The administration of the death receptor agonist blocks fibroblast or profibrogenic cell activation, and/or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.

公开(公告)号：EP3411121A1

公开(公告)日：2018-12-12

申请号：EP17748283.3

申请日：2017-02-03

申请人： The Johns Hopkins University

发明人： LIU, Jun ,  HE, Qingli ,  POMPER, Martin, G. ,  MINN, Ii ,  YU, Biao ,  WANG, Qiaoling

IPC分类号： A61P35/00 ,  A61P37/06 ,  C07D493/22

CPC分类号： C07D493/22 ,  C07J73/003

摘要： Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti -proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.

公开(公告)号：EP1768704B9

公开(公告)日：2013-01-02

申请号：EP05788432.2

申请日：2005-06-20

申请人： The Johns Hopkins University

发明人： POMPER, Martin, G. ,  BETTEGOWDA, Chetan ,  FOSS, Catherine ,  ZHOU, Shibin room 589 Cancer Research Bldg ,  KINZLER, Kenneth room 589 Cancer Research Bldg ,  VOGELSTEIN, Bert room 589 Cancer Research Bldg

IPC分类号： A61K49/00

CPC分类号： A61K51/1241 ,  A61K51/0491 ,  A61K51/1231

公开(公告)号：EP3439687A1

公开(公告)日：2019-02-13

申请号：EP17719426.3

申请日：2017-04-07

申请人： The Johns Hopkins University

发明人： LEE, Seulki ,  POMPER, Martin, G. ,  PARK, Ogyi ,  SWIERCZEWSKA, Magdalena ,  PASRICHA, Pankaj, J.

IPC分类号： A61K38/19 ,  A61P1/18 ,  C07K16/28 ,  A61P25/04

公开(公告)号：EP1768704B1

公开(公告)日：2012-05-02

申请号：EP05788432.2

申请日：2005-06-20

申请人： The Johns Hopkins University

发明人： POMPER, Martin, G. ,  BETTEGOWDA, Chetan ,  FOSS, Catherine ,  ZHOU, Shibin room 589 Cancer Research Bldg ,  KINZLER, Kenneth room 589 Cancer Research Bldg ,  VOGELSTEIN, Bert room 589 Cancer Research Bldg

IPC分类号： A61K49/00

CPC分类号： A61K51/1241 ,  A61K51/0491 ,  A61K51/1231

摘要： The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.

公开(公告)号：EP2958891A1

公开(公告)日：2015-12-30

申请号：EP14753892.0

申请日：2014-02-21

申请人： The Johns Hopkins University

发明人： POMPER, Martin, G. ,  WANG, Haofan ,  MINN, Il ,  LEACH, Steven, D. ,  MEASE, Ronnie, Charles

IPC分类号： C07D207/00 ,  C07D209/00 ,  G01N21/64

CPC分类号： G01N21/6428 ,  C07D207/44 ,  C07F5/022 ,  G01N21/6486 ,  G01N2021/6439

摘要： A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.

公开(公告)号：EP1472541B1

公开(公告)日：2009-09-16

申请号：EP03703745.4

申请日：2003-01-10

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： POMPER, Martin, G. ,  ZHANG, Jiazong ,  KOZIKOWSKI, Alan, P. ,  MUSACHIO, John, L.

IPC分类号： G01N33/60 ,  C07C275/24 ,  C07C275/16 ,  C07C323/59 ,  A61K31/17 ,  A61P35/00

CPC分类号： A61K51/0402 ,  A61B6/508 ,  A61K49/0032 ,  A61K49/0052 ,  C07B2200/05 ,  C07C275/24 ,  C07C323/59 ,  C07F11/005 ,  C12Q1/37 ,  G01N33/5005 ,  G01N33/60 ,  G01N33/62 ,  G01N33/689 ,  G01N2333/705

摘要： The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity. In another embodiment, the invention relates to pharmaceutical compositions containing urea compounds.

公开(公告)号：EP1768704A2

公开(公告)日：2007-04-04

申请号：EP05788432.2

申请日：2005-06-20

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： POMPER, Martin, G. ,  BETTEGOWDA, Chetan ,  FOSS, Catherine ,  ZHOU, Shibin room 589 Cancer Research Bldg ,  KINZLER, Kenneth room 589 Cancer Research Bldg ,  VOGELSTEIN, Bert room 589 Cancer Research Bldg

IPC分类号： A61K49/00

CPC分类号： A61K51/1241 ,  A61K51/0491 ,  A61K51/1231

摘要： The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.

公开(公告)号：EP1472541A1

公开(公告)日：2004-11-03

申请号：EP03703745.4

申请日：2003-01-10

申请人： The Johns Hopkins University

发明人： POMPER, Martin, G. ,  ZHANG, Jiazong ,  KOZIKOWSKI, Alan, P. ,  MUSACHIO, John, L.

IPC分类号： G01N33/60 ,  C07C275/24 ,  C07C275/16 ,  C07C323/59 ,  A61K31/17 ,  A61P35/00

CPC分类号： A61K51/0402 ,  A61B6/508 ,  A61K49/0032 ,  A61K49/0052 ,  C07B2200/05 ,  C07C275/24 ,  C07C323/59 ,  C07F11/005 ,  C12Q1/37 ,  G01N33/5005 ,  G01N33/60 ,  G01N33/62 ,  G01N33/689 ,  G01N2333/705

摘要： The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express NAALADase and/or PSMA to which the compounds of the invention have an affinity. In another embodiment, the invention relates to pharmaceutical compositions containing urea compounds.