公开(公告)号：EP4210823A1

公开(公告)日：2023-07-19

申请号：EP21867767.2

申请日：2021-09-13

申请人： The Regents of The University of Michigan

发明人： XU, Zhen ,  NOLL, Douglas ,  HALL, Timothy, L.

IPC分类号： A61N7/02 ,  A61B5/055 ,  A61B90/00 ,  G01R33/48

公开(公告)号：EP4322871A1

公开(公告)日：2024-02-21

申请号：EP22789004.3

申请日：2022-04-15

申请人： The Regents of The University of Michigan

发明人： XU, Zhen ,  HALL, Timothy Lewis ,  LUNDT, Jonathan E.

IPC分类号： A61B17/225

公开(公告)号：EP4351447A1

公开(公告)日：2024-04-17

申请号：EP22820730.4

申请日：2022-04-07

申请人： The Regents of The University of Michigan

发明人： XU, Zhen ,  HALL, Timothy, Lewis ,  SUKOVICH, Jonathan

IPC分类号： A61B17/22 ,  A61B17/225 ,  A61B8/00 ,  A61N7/02

CPC分类号： A61N7/02 ,  A61B8/5261 ,  A61B8/4488 ,  A61B8/483

公开(公告)号：EP4230262A2

公开(公告)日：2023-08-23

申请号：EP23169575.0

申请日：2016-06-23

申请人： The Regents Of The University Of Michigan

发明人： XU, Zhen ,  SUKOVICH, Jonathan ,  PANDEY, Aditya, S. ,  CAIN, Charles, A. ,  GURM, Hitinder, S.

IPC分类号： A61N7/00

摘要： A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

公开(公告)号：EP4087493A1

公开(公告)日：2022-11-16

申请号：EP21738971.7

申请日：2021-01-07

申请人： The Regents Of The University Of Michigan

发明人： XU, Zhen ,  PANDEY, Adita, S. ,  SUKOVICH, Jonathan ,  GERHARDSON, Tyler ,  CHOI, Sang Won

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B8/13 ,  A61B8/14 ,  A61B34/20

公开(公告)号：EP4230262A3

公开(公告)日：2023-11-22

申请号：EP23169575.0

申请日：2016-06-23

申请人： The Regents Of The University Of Michigan

发明人： XU, Zhen ,  SUKOVICH, Jonathan ,  PANDEY, Aditya, S. ,  CAIN, Charles, A. ,  GURM, Hitinder, S.

IPC分类号： A61N7/00

摘要： A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

公开(公告)号：EP2903688A1

公开(公告)日：2015-08-12

申请号：EP13844243.9

申请日：2013-10-04

申请人： The Regents of The University of Michigan

发明人： XU, Zhen ,  MILLER, Ryan M. ,  MAXWELL, Adam ,  CAIN, Charles A.

IPC分类号： A61N7/00 ,  A61B8/00 ,  A61B18/00

CPC分类号： A61B8/488 ,  A61B5/0035 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/4848 ,  A61B8/54 ,  A61B8/543 ,  A61B17/22012 ,  A61B17/2258 ,  G01S15/8979 ,  G01S15/8981 ,  G01S15/899

摘要： A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

公开(公告)号：EP2470087B1

公开(公告)日：2015-03-25

申请号：EP10814303.3

申请日：2010-08-26

申请人： The Regents of The University of Michigan ,  Histosonics, Inc.

发明人： CAIN, Charles A. ,  HALL, Timothy L. ,  ROBERTS, William W. ,  XU, Zhen ,  FOWLKES, J. Brian ,  DAVISON, Thomas W.

IPC分类号： A61B17/225 ,  A61B18/26 ,  A61B6/12 ,  A61B8/00

CPC分类号： A61N7/00 ,  A61B8/00 ,  A61B17/225 ,  A61B17/2256 ,  A61B2017/00172 ,  A61B2017/22008 ,  A61B2090/378

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.

公开(公告)号：EP2844343A1

公开(公告)日：2015-03-11

申请号：EP13784385.0

申请日：2013-04-30

申请人： The Regents Of The University Of Michigan

发明人： HALL, Timothy L. ,  MAXWELL, Adam ,  CAIN, Charles A. ,  KIM, Yohan ,  XU, Zhen

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B17/225 ,  A61B17/320068 ,  A61B2017/00526 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0091 ,  A61N2007/0095 ,  B06B1/0607 ,  B33Y10/00 ,  B33Y80/00 ,  G01N29/223 ,  G01N29/225 ,  G01N29/226 ,  G01N29/2437 ,  G01N29/245 ,  G10K11/004 ,  H01L41/04 ,  H01L41/053 ,  H01L41/1876 ,  H01L41/23 ,  H01L41/25 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49007

摘要： An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.

摘要翻译： 提供了可以包括任何数量的特征的超声治疗系统。 在一些实施例中，定制换能器壳体可以使用快速原型方法制造，以布置多个单元件，基本上平坦的换能器以共享公共焦点。 快速成型方法可以包括例如熔融沉积建模，3D印刷和立体光刻。 在一些实施例中，治疗系统可以包括可插入换能器壳体的开口中的多个换能器模块。 每个换能器模块可以包括声透镜，基本平坦的单元件换能器以及设置在透镜和换能器之间的匹配层。 还描述了使用和制造方法。

公开(公告)号：EP2470087A2

公开(公告)日：2012-07-04

申请号：EP10814303.3

申请日：2010-08-26

申请人： The Regents of The University of Michigan ,  Histosonics, Inc.

发明人： CAIN, Charles A. ,  HALL, Timothy L. ,  ROBERTS, William, W. ,  XU, Zhen ,  FOWLKES, J. Brian ,  DAVISON, Thomas W.

IPC分类号： A61B17/225 ,  A61B18/26 ,  A61B6/12 ,  A61B8/00

CPC分类号： A61N7/00 ,  A61B8/00 ,  A61B17/225 ,  A61B17/2256 ,  A61B2017/00172 ,  A61B2017/22008 ,  A61B2090/378

摘要： A medical imaging and therapy device is provided that may include any of a number of features. One feature of the device is that it can deliver Lithotripsy therapy to a patient, so as to fractionate urinary stones. Another feature of the device is that it can deliver Histotripsy therapy to a patient, so as to erode urinary stones. In some embodiments, the medical imaging and therapy device is configured to target and track urinary stones in the patient during therapy. Methods associated with use of the medical imaging and therapy device are also covered.