公开(公告)号：EP3271718A1

公开(公告)日：2018-01-24

申请号：EP16765771.7

申请日：2016-03-17

申请人： The Regents of the University of California

发明人： HO, Dean ,  HO, Chih-Ming ,  ZARRINPAR, Ali ,  LEE, Dong-Keun ,  VITE, Aleidy Marlene Silva ,  DATTA, Nakul

IPC分类号： G01N33/15 ,  G01N33/50 ,  G06F19/12

CPC分类号： G06F19/704 ,  G06F19/18 ,  G06F19/3456 ,  G16H20/10

摘要： An initial phenotypic map is derived for a patient subjected to an initial therapeutic regimen including a first drug, based on values of a therapeutic outcome for the patient and corresponding values of a dose of the first drug administered to the patient. Following a change from the initial therapeutic regimen to an updated therapeutic regimen, an updated value of the therapeutic outcome is received for the patient subjected to the updated therapeutic regimen. The initial phenotypic map is re-calibrated according to the updated value of the therapeutic outcome, and, using the re-calibrated phenotypic map, identication is made of a value of the dose of the first drug to be administered to the patient subjected to the updated therapeutic regimen.

公开(公告)号：EP0878013B1

公开(公告)日：2004-05-06

申请号：EP96920094.8

申请日：1996-01-19

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： HO, Chih-Ming ,  MIU, Denny, K. ,  LEU, Jeremy, Tzong-Shyng ,  MILLER, Raanan ,  DESAI, Amish ,  LIU, Chang ,  TSAO, Tom ,  TAI, Yu-Chong

IPC分类号： H01F7/00 ,  H02K57/00

CPC分类号： H02K99/00

公开(公告)号：EP4388544A1

公开(公告)日：2024-06-26

申请号：EP22859328.1

申请日：2022-08-16

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  University of Florida Research Foundation, Incorporated

发明人： HO, Chih-Ming ,  KHONG, Jeffrey ,  LEE, Megan ,  ZARRINPAR, Ali ,  KIM, Un Bi ,  WARREN, Curtis

IPC分类号： G16H20/10 ,  G16H50/70 ,  G16H70/40 ,  A61P37/06 ,  G16H20/17

CPC分类号： A61P37/06 ,  G16H20/10

公开(公告)号：EP3291819A1

公开(公告)日：2018-03-14

申请号：EP16790033.1

申请日：2016-05-04

申请人： The Regents of the University of California ,  National University of Singapore

发明人： HO, Dean ,  HO, Chih-Ming ,  VITE, Aleidy Marlene Silva ,  ZHANG, Kangyi ,  CHOW, Edward Kai-Hua ,  TOH, Tan Boon ,  CHNG, Wee Joo ,  RASHID, Masturah Mohd Abdul

IPC分类号： A61K31/706 ,  A61K31/407 ,  A61K31/69 ,  A61K31/13 ,  A61K31/573 ,  A61K31/404 ,  A61P35/00

CPC分类号： A61K31/706 ,  A61K31/131 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/573 ,  A61K31/69 ,  A61K38/05 ,  A61K2300/00

摘要： Disclosed are pharmaceutical compositions and methods of treating multiple myeloma by providing a pharmaceutically effective amount of each drug in a combination of drugs.

公开(公告)号：EP3027763B1

公开(公告)日：2018-05-30

申请号：EP14831626.8

申请日：2014-07-29

申请人： The Regents of the University of California

发明人： CHEN, Yong ,  HO, Chih-Ming

IPC分类号： B82Y10/00 ,  G06F17/11 ,  G06F19/12 ,  G06F19/00 ,  G01N33/50

CPC分类号： A61K49/0008 ,  G01N33/5008 ,  G06F19/70 ,  G16H50/50

摘要： A method includes: (1) applying stimulations to a system, wherein applying the stimulations includes modulating, over time, characteristics of the stimulations; (2) measuring a time-varying response of the system to the stimulations; (3) fitting the time-varying response of the system into a model of the system; and (4) using the model of the system, identifying an optimized combination of characteristics of the stimulations to yield a desired response of the system.

公开(公告)号：EP3027763A1

公开(公告)日：2016-06-08

申请号：EP14831626.8

申请日：2014-07-29

申请人： The Regents of the University of California

发明人： CHEN, Yong ,  HO, Chih-Ming

IPC分类号： C12Q1/02 ,  G01N33/15

CPC分类号： A61K49/0008 ,  G01N33/5008 ,  G06F19/70 ,  G16H50/50

摘要： A method includes: (1) applying stimulations to a system, wherein applying the stimulations includes modulating, over time, characteristics of the stimulations; (2) measuring a time-varying response of the system to the stimulations; (3) fitting the time-varying response of the system into a model of the system; and (4) using the model of the system, identifying an optimized combination of characteristics of the stimulations to yield a desired response of the system.

公开(公告)号：EP3215225A1

公开(公告)日：2017-09-13

申请号：EP15857307.1

申请日：2015-11-03

申请人： The Regents of the University of California ,  Shanghai Jiao Tong University

发明人： HO, Chih-Ming ,  CLEMENS, Daniel L. ,  CLEMENS, Bai-Yu Lee ,  HORWITZ, Marcus Aaron ,  SILVA VITE, Aleidy Marlene ,  KEE, Theodore ,  DING, Xianting

IPC分类号： A61P31/06 ,  A61K31/133 ,  A61K31/4965 ,  A61K31/498

摘要： The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

摘要翻译： 本发明涉及通过提供药学有效量的药物化合物组合治疗结核病的方法。

公开(公告)号：EP0878013A2

公开(公告)日：1998-11-18

申请号：EP96920094.0

申请日：1996-01-19

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： HO, Chih-Ming ,  MIU, Denny, K. ,  LEU, Jeremy, Tzong-Shyng ,  MILLER, Raanan ,  DESAI, Amish ,  LIU, Chang ,  TSAO, Tom ,  TAI, Yu-Chong

IPC分类号： H02K57

CPC分类号： H02K99/00

摘要： A surface micromachined micromagnetic actuator is provided with a flap (14) using magnetic force as the actuating force. The flap is coupled by one or more beams (16) to a substrate and is cantilevered over the substrate. A Permalloy layer or a magnetic coil (12) is disposed on the flap such that when the flap is placed in a magnetic field, it can be caused to selectively interact and rotate out of the plane of the magnetic actuator. The cantilevered flap is released from the underlying substrate by etching out an underlying sacrificial layer disposed between the flap and the substrate (22). The etched out and now cantilevered flap is magnetically actuated to maintain it out of contact with the substrate while the just etched device is dried in order to obtain high release yields.

公开(公告)号：EP3215225B1

公开(公告)日：2020-01-08

申请号：EP15857307.1

申请日：2015-11-03

申请人： The Regents of the University of California

发明人： HO, Chih-Ming ,  CLEMENS, Daniel L. ,  CLEMENS, Bai-Yu Lee ,  HORWITZ, Marcus Aaron ,  SILVA VITE, Aleidy Marlene ,  KEE, Theodore ,  DING, Xianting

IPC分类号： A61P31/06 ,  A61K31/133 ,  A61K31/4965 ,  A61K31/498

公开(公告)号：EP2946263A1

公开(公告)日：2015-11-25

申请号：EP14741090.6

申请日：2014-01-17

申请人： The Regents of the University of California

发明人： HO, Chih-Ming ,  DING, Xianting ,  WONG, Ieong

IPC分类号： G06F3/00

CPC分类号： G16H50/50 ,  G06F17/11 ,  G06F17/5009 ,  G06F19/00 ,  G06F19/12 ,  G06F19/326 ,  G06F19/707 ,  G16H10/20

摘要： Multiple tests of a complex system are conducted by applying varying combinations of input parameters from a pool of input parameters. Results of the tests are fitted into a model of the complex system by using multi-dimensional fitting. Using the model of the complex system, identification is made of at least one optimized combination of input parameters to yield a desired response of the complex system.